2023
146-OR: Causative Role of Hypothalamic Ventromedial Glucose-Inhibited Neurons in Impaired Counterregulatory Responses to Hypoglycemia
COPPERI F, SHEN X, DIANO S. 146-OR: Causative Role of Hypothalamic Ventromedial Glucose-Inhibited Neurons in Impaired Counterregulatory Responses to Hypoglycemia. Diabetes 2023, 72 DOI: 10.2337/db23-146-or.Peer-Reviewed Original ResearchImpaired counterregulatory responseCounterregulatory responsesGI neuronsRecurrent hypoglycemiaCausative roleGlucose-inhibited neuronsType 1 diabetesBlood glucose levelsScientific evidence pointsDiabetes CenterChemogenetic activationKidney diseaseVentromedial nucleusNeuronal activationGlucose levelsMouse modelCurrent evidenceConsecutive daysMiceNeuronsAdministrationSignificant decreaseCausal involvementNational InstituteHypoglycemia
2017
DRP1 Suppresses Leptin and Glucose Sensing of POMC Neurons
Santoro A, Campolo M, Liu C, Sesaki H, Meli R, Liu ZW, Kim JD, Diano S. DRP1 Suppresses Leptin and Glucose Sensing of POMC Neurons. Cell Metabolism 2017, 25: 647-660. PMID: 28190775, PMCID: PMC5366041, DOI: 10.1016/j.cmet.2017.01.003.Peer-Reviewed Original ResearchConceptsPeroxisome proliferator-activated receptorPOMC neuronsLeptin sensitivityHypothalamic pro-opiomelanocortin (POMC) neuronsPro-opiomelanocortin (POMC) neuronsCounter-regulatory responseProliferator-activated receptorMitochondrial sizeFed miceGlucoprivic stimuliNeuronal activationFl/Glucose metabolismMetabolic environmentNeuronsFasted animalsIntracellular mechanismsReduced expressionGlucose responsivenessGreater activationInducible deletionROS productionMiceStrong inhibitionMitochondrial fission regulator