1995
vpr deletion mutant of simian immunodeficiency virus induces AIDS in rhesus monkeys
Hoch J, Lang S, Weeger M, Stahl-Hennig C, Coulibaly C, Dittmer U, Hunsmann G, Fuchs D, Müller J, Sopper S. vpr deletion mutant of simian immunodeficiency virus induces AIDS in rhesus monkeys. Journal Of Virology 1995, 69: 4807-4813. PMID: 7609047, PMCID: PMC189293, DOI: 10.1128/jvi.69.8.4807-4813.1995.Peer-Reviewed Original ResearchProgression to AIDS in the absence of a gene for vpr or vpx
Gibbs J, Lackner A, Lang S, Simon M, Sehgal P, Daniel M, Desrosiers R. Progression to AIDS in the absence of a gene for vpr or vpx. Journal Of Virology 1995, 69: 2378-2383. PMID: 7884883, PMCID: PMC188910, DOI: 10.1128/jvi.69.4.2378-2383.1995.Peer-Reviewed Original ResearchConceptsLow virus burdenSimian immunodeficiency virusVirus burdenRhesus monkeysLymphocyte concentrationsPlasma antigenemiaHigh virus burdenLymph node morphologyImmunodeficiency virusDisease progressionSIVmac replicationPrimate lentivirusesVirus replicationWild-type virusNode morphologyAIDSVpx geneTerminal stageProgressionAntigenemiaCD4VpxMonkeysEarly spikeBurden
1993
Importance of vpr for infection of rhesus monkeys with simian immunodeficiency virus
Lang S, Weeger M, Stahl-Hennig C, Coulibaly C, Hunsmann G, Müller J, Müller-Hermelink H, Fuchs D, Wachter H, Daniel M. Importance of vpr for infection of rhesus monkeys with simian immunodeficiency virus. Journal Of Virology 1993, 67: 902-912. PMID: 8380472, PMCID: PMC237444, DOI: 10.1128/jvi.67.2.902-912.1993.Peer-Reviewed Original ResearchConceptsVpr variantsTAA stop codonVpr geneATG start codonSite-specific mutagenesisVpr mutant virusSignificant selective pressureImportance of VprStart codonSelective pressureVpr mutantsStop codonGenesPathogenic molecular cloneMolecular cloneCell linesVprTest animalsCEMx174 cell lineCodonNef geneSimilar kineticsVirus replicationReversionStop signal