Expanded NK cells used for adoptive cell therapy maintain diverse clonality and contain long-lived memory-like NK cell populations
Allan D, Wu C, Mortlock R, Chakraborty M, Rezvani K, Davidson-Moncada J, Dunbar C, Childs R. Expanded NK cells used for adoptive cell therapy maintain diverse clonality and contain long-lived memory-like NK cell populations. Molecular Therapy — Oncolytics 2022, 28: 74-87. PMID: 36699615, PMCID: PMC9842935, DOI: 10.1016/j.omto.2022.12.006.Peer-Reviewed Original ResearchBarcode clonal tracking of tissue-resident immune cells in rhesus macaque highlights distinct clonal distribution pattern of tissue NK cells
Wu C, Liang J, Brenchley J, Shin T, Fan X, Mortlock R, Abraham D, Allan D, Thomas M, Hong S, Dunbar C. Barcode clonal tracking of tissue-resident immune cells in rhesus macaque highlights distinct clonal distribution pattern of tissue NK cells. Frontiers In Immunology 2022, 13: 994498. PMID: 36605190, PMCID: PMC9808525, DOI: 10.3389/fimmu.2022.994498.Peer-Reviewed Original ResearchConceptsTissue-resident immune cellsNK cellsPeripheral bloodCD56-CD16NK memoryNK clonesImmune cellsImmunological memoryT cellsNatural killer cell populationsClonal expansionDevelopment of NKTissue NK cellsResident immune cellsClonal distributionKiller cell populationsBlood T cellsCD16-CD56NK subsetsAutologous transplantationImmune responseGastrointestinal tractGI tractMyeloid cellsDN populationTissue Trafficking Kinetics of Rhesus Macaque Natural Killer Cells Measured by Serial Intravascular Staining
Mortlock RD, Wu C, Potter EL, Abraham DM, Allan DSJ, Hong SG, Roederer M, Dunbar CE. Tissue Trafficking Kinetics of Rhesus Macaque Natural Killer Cells Measured by Serial Intravascular Staining. Frontiers In Immunology 2022, 12: 772332. PMID: 35095846, PMCID: PMC8790741, DOI: 10.3389/fimmu.2021.772332.Peer-Reviewed Original ResearchConceptsNatural killer cellsNK cellsKiller cellsPeripheral bloodIntravascular stainingHuman NK cell biologyRhesus macaquesNK cell subsetsNK cell biologyTissue distributionNon-lymphoid tissuesNK compartmentLymph nodesCell subsetsAnimal modelsRM tissuesCD16Perivascular compartmentTrafficking patternsTissueBloodHigher proportionStainingCellsDifferent subsets