BRCA2: one small step for DNA repair, one giant protein purified.
Jensen RB. BRCA2: one small step for DNA repair, one giant protein purified. The Yale Journal Of Biology And Medicine 2013, 86: 479-89. PMID: 24348212, PMCID: PMC3848102.Peer-Reviewed Original ResearchMeSH KeywordsBRCA2 ProteinDNADNA RepairHomologous RecombinationHumansModels, GeneticNeoplasmsProtein BindingRad51 RecombinaseSignal TransductionConceptsHomologous recombinationDNA repairDNA double-strand break repairActivity of Rad51Double-strand break repairDNA double-strand breaksReplication protein A.Homologous DNA sequencesDouble-strand breaksCurrent biochemical dataHigh-fidelity repairRole of BRCA2Faithful repairRad51 proteinNucleoprotein filamentBreak repairSingle-strand DNADNA sequencesGenomic instabilityDNA breaksGiant proteinRAD51Gene BRCA2BRCA2 proteinCentral playerCell-interdependent cisplatin killing by Ku/DNA-dependent protein kinase signaling transduced through gap junctions
Jensen R, Glazer PM. Cell-interdependent cisplatin killing by Ku/DNA-dependent protein kinase signaling transduced through gap junctions. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 6134-6139. PMID: 15069205, PMCID: PMC395935, DOI: 10.1073/pnas.0400051101.Peer-Reviewed Original ResearchConceptsDNA-dependent protein kinase (DNA-PK) complexDNA-dependent protein kinase activityDNA-dependent protein kinaseProtein kinase complexProtein kinase activityCell-autonomous mannerGap junctionsBlock transcriptionKinase complexKinase functionProtein kinaseDeath signalsDNA repairCell communicationKinase activityRecipient cellsCellular componentsGap junction expressionHuman cancersNeighboring cellsDirect cellCell killingMechanism of actionCellsJunction expression