Measurement and immunophenotyping of pleural fluid EpCAM-positive cells and clusters for the management of non-small cell lung cancer patients
Thompson J, Fan R, Black T, Yu G, Savitch S, Chien A, Yee S, Sen M, Hwang W, Katz S, Feldman M, Vachani A, Carpenter E. Measurement and immunophenotyping of pleural fluid EpCAM-positive cells and clusters for the management of non-small cell lung cancer patients. Lung Cancer 2018, 127: 25-33. PMID: 30642547, PMCID: PMC6657687, DOI: 10.1016/j.lungcan.2018.11.020.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerMalignant pleural effusionPleural fluid samplesEpCAM-positive cellsPD-L1 expressionNSCLC patientsOverall survivalPrognostic informationNon-small cell lung cancer patientsFluid samplesCell lung cancer patientsCox proportional hazards modelInferior overall survivalKaplan-Meier methodNon-malignant groupCell lung cancerLung cancer patientsProportional hazards modelPleural fluid specimensCommon complicationPD-L1Pleural effusionCurrent gold standardCancer patientsLung cancer