2020
Single-Cell Transcriptional Archetypes of Airway Inflammation in Cystic Fibrosis.
Schupp JC, Khanal S, Gomez JL, Sauler M, Adams TS, Chupp GL, Yan X, Poli S, Zhao Y, Montgomery RR, Rosas IO, Dela Cruz CS, Bruscia EM, Egan ME, Kaminski N, Britto CJ. Single-Cell Transcriptional Archetypes of Airway Inflammation in Cystic Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2020, 202: 1419-1429. PMID: 32603604, PMCID: PMC7667912, DOI: 10.1164/rccm.202004-0991oc.Peer-Reviewed Original ResearchConceptsCF lung diseaseHealthy control subjectsImmune dysfunctionLung diseaseCystic fibrosisControl subjectsSputum cellsAbnormal chloride transportLung mononuclear phagocytesInnate immune dysfunctionDivergent clinical coursesImmune cell repertoireMonocyte-derived macrophagesCF monocytesAirway inflammationClinical courseProinflammatory featuresCell survival programInflammatory responseTissue injuryCell repertoireImmune functionTranscriptional profilesAlveolar macrophagesMononuclear phagocytes
2015
Leukocyte-specific protein 1 regulates T-cell migration in rheumatoid arthritis
Hwang SH, Jung SH, Lee S, Choi S, Yoo SA, Park JH, Hwang D, Shim SC, Sabbagh L, Kim KJ, Park SH, Cho CS, Kim BS, Leng L, Montgomery RR, Bucala R, Chung YJ, Kim WU. Leukocyte-specific protein 1 regulates T-cell migration in rheumatoid arthritis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: e6535-e6543. PMID: 26554018, PMCID: PMC4664344, DOI: 10.1073/pnas.1514152112.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArthritis, ExperimentalArthritis, RheumatoidCalcium-Binding ProteinsCell MovementCells, CulturedChronic DiseaseExtracellular Signal-Regulated MAP KinasesGene DosageGene Expression ProfilingGenetic Predisposition to DiseaseHumansHypersensitivity, DelayedInflammationMiceMicrofilament ProteinsPhosphorylationReceptors, Antigen, T-CellT-LymphocytesConceptsT cell migrationRheumatoid arthritisT cellsImmune dysfunctionPathogenesis of RAPeripheral T cellsT cell activationT cell receptor activationProtein expression levelsLymph nodesChronic inflammationCytokine responsesInflamed synoviumAutoimmune diseasesLeukocyte-specific protein 1Primary T cellsRA susceptibilityReceptor activationDisease severityMigratory capacityLSP1 geneDiminished expressionTarget tissuesCell motilityProtein 1