2009
Genome-wide screen of promoter methylation identifies novel markers in melanoma
Koga Y, Pelizzola M, Cheng E, Krauthammer M, Sznol M, Ariyan S, Narayan D, Molinaro AM, Halaban R, Weissman SM. Genome-wide screen of promoter methylation identifies novel markers in melanoma. Genome Research 2009, 19: 1462-1470. PMID: 19491193, PMCID: PMC2720187, DOI: 10.1101/gr.091447.109.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdultAgedBiomarkers, TumorCells, CulturedCluster AnalysisCollagenCollagen Type IDNA MethylationFemaleGene Expression ProfilingGenome, HumanGenome-Wide Association StudyHSP20 Heat-Shock ProteinsHumansInfant, NewbornMaleMelanomaMetallothioneinMiddle AgedMolecular ChaperonesNuclear ProteinsNucleoplasminsOligonucleotide Array Sequence AnalysisPhosphoproteinsPromoter Regions, GeneticProteinsReproducibility of ResultsReverse Transcriptase Polymerase Chain ReactionSequence Analysis, DNATumor Cells, CulturedConceptsDifferential gene expressionGene expressionPromoter methylationGenome-wide promoter methylationGenome-wide integrative analysisPromoter CpG contentMethylation markersGenome-wide screenSequencing of bisulfiteTranscription start siteMelanoma cell strainsCell strainsTranscriptional machineryNovel genesEpigenetic modificationsDNA methylationIdentifies novel markersStart siteSnap-frozen tissuesCpG contentAdult melanocytesIntegrative analysisReal-time reverse transcriptase PCRHuman diseasesMethylation
2007
XAF1 Mediates Tumor Necrosis Factor-α-induced Apoptosis and X-linked Inhibitor of Apoptosis Cleavage by Acting through the Mitochondrial Pathway*
Straszewski-Chavez SL, Visintin IP, Karassina N, Los G, Liston P, Halaban R, Fadiel A, Mor G. XAF1 Mediates Tumor Necrosis Factor-α-induced Apoptosis and X-linked Inhibitor of Apoptosis Cleavage by Acting through the Mitochondrial Pathway*. Journal Of Biological Chemistry 2007, 282: 13059-13072. PMID: 17329253, DOI: 10.1074/jbc.m609038200.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingApoptosisApoptosis Regulatory ProteinsCell SurvivalCells, CulturedFas ReceptorFemaleHumansIntracellular Signaling Peptides and ProteinsMitochondriaNeoplasm ProteinsPregnancyPregnancy Trimester, FirstPregnancy Trimester, ThirdTrophoblastsTumor Necrosis Factor-alphaX-Linked Inhibitor of Apoptosis ProteinConceptsThird trimester trophoblast cellsOverexpression of XAF1Fas ligand-induced apoptosisCaspase inhibitory activityTNF-alpha-induced apoptosisMembrane-bound death receptorsNovel regulatory pathwayLigand-induced apoptosisTrophoblast cellsXIAP inactivationMitochondrial pathwayRegulatory pathwaysDeath receptorsProapoptotic proteinsMolecular mechanismsApoptotic cascadeFirst trimester trophoblast cellsDifferential expressionXAF1XAF1 expressionCell survivalInduces ApoptosisGene methylationApoptosisPathway