2002
COMMENTARY Pigmentation in Melanomas: Changes Manifesting Underlying Oncogenic and Metabolic Activities
Halaban R. COMMENTARY Pigmentation in Melanomas: Changes Manifesting Underlying Oncogenic and Metabolic Activities. Oncology Research Featuring Preclinical And Clinical Cancer Therapeutics 2002, 13: 3-8. PMID: 12201672, DOI: 10.3727/096504002108747908.Peer-Reviewed Original ResearchConceptsMelanocyte-specific gene expressionTranscription factor MITFDownregulation of tyrosinaseEpigenetic levelV-ATPaseRate-limiting enzymeTranscriptional activityGene expressionAcidified microenvironmentsAmelanotic melanoma cellsC-MycActivity of tyrosinaseEnhanced glycolysisMelanin synthesisExtracellular acidificationMelanoma tumorsTYR activityMelanoma cellsMetabolic activityPigmentationAnaerobic conditionsTyrosinase activityMetastatic melanocytic lesionsMetabolic changesTyrosinase
1990
Murine and human b locus pigmentation genes encode a glycoprotein (gp75) with catalase activity.
Halaban R, Moellmann G. Murine and human b locus pigmentation genes encode a glycoprotein (gp75) with catalase activity. Proceedings Of The National Academy Of Sciences Of The United States Of America 1990, 87: 4809-4813. PMID: 1693779, PMCID: PMC54207, DOI: 10.1073/pnas.87.12.4809.Peer-Reviewed Original ResearchConceptsPigmentation genesRapid proteolytic degradationMelanosomal glycoproteinLocus proteinBrown locusCatalase BB mutationsProteolytic degradationB locusMelanogenic activityGenesMelanin precursorsLociProteinMutationsGlycoproteinCatalase activityTyrosinaseHydrogen peroxideHydroperoxidaseMelanogenesisGp75ActivityMurinePigmentation
1980
Pigmentation and tumorigenicity of reconstituted, cybrid and hybrid mouse cells
Halaban R, Moellmann G, Godawska E, Eisenstadt J. Pigmentation and tumorigenicity of reconstituted, cybrid and hybrid mouse cells. Experimental Cell Research 1980, 130: 427-435. PMID: 7449860, DOI: 10.1016/0014-4827(80)90021-x.Peer-Reviewed Original ResearchConceptsWhole cellsHybrid cellsSuppression of tumorigenicityMelanoma genomeMelanocytic functionNon-tumorigenic fibroblastsDonor parentMouse cellsCybridsStable expressionCytoplasmic transferCellular fragmentsTumorigenicityExpressionCytoplastsCellsViral particlesMurine melanomaGenomeChromosomesNucleoplastsPhenotypeExtinctionComparable numberPigmentation