1998
Release of cell cycle constraints in mouse melanocytes by overexpressed mutant E2F1E132, but not by deletion of p16INK4A or p21WAF1/CIP1
Halaban R, Cheng E, Zhang Y, Mandigo C, Miglarese M. Release of cell cycle constraints in mouse melanocytes by overexpressed mutant E2F1E132, but not by deletion of p16INK4A or p21WAF1/CIP1. Oncogene 1998, 16: 2489-2501. PMID: 9627115, DOI: 10.1038/sj.onc.1201773.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsCell CycleCell Cycle ProteinsCell SurvivalCyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor p21CyclinsDNA-Binding ProteinsE2F Transcription FactorsE2F1 Transcription FactorGene Expression RegulationHumansMelanocytesMiceMice, NudeMutagenesisProtein BiosynthesisRecombinant Fusion ProteinsRetinoblastoma ProteinRetinoblastoma-Binding Protein 1Tetradecanoylphorbol AcetateTranscription Factor DP1Transcription FactorsConceptsP21WAF1/CIP1Cell cycle progressionMouse melanocytesTarget genesCycle progressionRetinoblastoma tumor suppressor proteinE2F-mediated transactivationCell cycle constraintsTumor suppressor proteinRole of E2F1Deletion of p16INK4AFree E2FExpression of RbGene disruptionSuppressor proteinEctopic expressionHallmark of melanomaTetradecanoyl phorbol 13Loss of p16INK4aConstitutive expressionMelanoma cell linesCell deathNormal melanocytesIndependent growthMelanocyte growth
1988
Paracrine Stimulation of Melanocytes by Keratinocytes through Basic Fibroblast Growth Factora
HALABAN R, LANGDON R, BIRCHALL N, CCUONO C, BAIRD A, SCOTT G, MOELLOMANN G, MCGUIRE J. Paracrine Stimulation of Melanocytes by Keratinocytes through Basic Fibroblast Growth Factora. Annals Of The New York Academy Of Sciences 1988, 548: 180-190. PMID: 2470294, DOI: 10.1111/j.1749-6632.1988.tb18805.x.Peer-Reviewed Original ResearchConceptsBasic fibroblast growth factorBFGF gene transcriptsGrowth factorNormal human melanocytesGene transcriptsFibroblast growth factorNatural growth factorsNorthern blotHuman melanocytesMelanocyte mitogensMelanocyte growthParacrine stimulationMelanocytesHuman keratinocytesSynthetic peptidesKeratinocytesUltraviolet BTranscriptsPresence of keratinocytesMitogenBindingBlotProliferationMonophosphateBasic fibroblast growth factor from human keratinocytes is a natural mitogen for melanocytes.
Halaban R, Langdon R, Birchall N, Cuono C, Baird A, Scott G, Moellmann G, McGuire J. Basic fibroblast growth factor from human keratinocytes is a natural mitogen for melanocytes. Journal Of Cell Biology 1988, 107: 1611-1619. PMID: 2459134, PMCID: PMC2115244, DOI: 10.1083/jcb.107.4.1611.Peer-Reviewed Original ResearchConceptsBasic fibroblast growth factorFibroblast growth factorBFGF gene transcriptsHuman melanocytesGrowth factorNormal human melanocytesNatural mitogenHuman keratinocytesGene transcriptsNatural growth factorsNorthern blotMelanocyte mitogensMelanocyte growthMelanocytesPure culturePresence of serumMitogenSynthetic peptidesKeratinocytesCellsCAMPTranscriptsPresence of keratinocytesBindingBlot