1990
Murine and human b locus pigmentation genes encode a glycoprotein (gp75) with catalase activity.
Halaban R, Moellmann G. Murine and human b locus pigmentation genes encode a glycoprotein (gp75) with catalase activity. Proceedings Of The National Academy Of Sciences Of The United States Of America 1990, 87: 4809-4813. PMID: 1693779, PMCID: PMC54207, DOI: 10.1073/pnas.87.12.4809.Peer-Reviewed Original ResearchConceptsPigmentation genesRapid proteolytic degradationMelanosomal glycoproteinLocus proteinBrown locusCatalase BB mutationsProteolytic degradationB locusMelanogenic activityGenesMelanin precursorsLociProteinMutationsGlycoproteinCatalase activityTyrosinaseHydrogen peroxideHydroperoxidaseMelanogenesisGp75ActivityMurinePigmentation
1983
Regulation of tyrosinase in human melanocytes grown in culture.
Halaban R, Pomerantz S, Marshall S, Lambert D, Lerner A. Regulation of tyrosinase in human melanocytes grown in culture. Journal Of Cell Biology 1983, 97: 480-488. PMID: 6411733, PMCID: PMC2112541, DOI: 10.1083/jcb.97.2.480.Peer-Reviewed Original ResearchConceptsHuman melanocytesApparent molecular weightMalignant human melanocytesTyrosinase activityMajor biochemical eventsExpression of tyrosinaseSynthesis of melaninRegulation of tyrosinasePosttranslational modificationsImmunoprecipitation experimentsO-glycosylationBiochemical eventsNormal melanocytesMelanocytesMolecular weightProteinEnzymeTyrosinaseTunicamycinAbundanceActivityRegulationHigh levelsLow levelsCulture
1978
Phenylalanine hydroxylase in melanoma cells
Breakefield X, Castiglione C, Halaban R, Pawelek J, Shiman R. Phenylalanine hydroxylase in melanoma cells. Journal Of Cellular Physiology 1978, 94: 307-314. PMID: 23386, DOI: 10.1002/jcp.1040940308.Peer-Reviewed Original ResearchConceptsPhenylalanine hydroxylase activityHydroxylase activityMelanoma cellsMelanoma cell extractsS91 melanoma cellsCloudman S91 melanoma cellsP-chlorophenylalanineTyrosine hydroxylasePhenylalanine hydroxylaseTryptophan hydroxylaseHydroxylaseConversion of phenylalanineSensitive assayTyrosinase activityCellsLiver phenylalanine hydroxylaseCell extractsSodium dodecyl sulfate-polyacrylamide gel electrophoresisDodecyl sulfate-polyacrylamide gel electrophoresisSulfate-polyacrylamide gel electrophoresisLatter activityActivity