2024
Photosensitive Nanoprobes for Rapid High Purity Isolation and Size‐Specific Enrichment of Synthetic and Extracellular Vesicle Subpopulations
Weerakkody J, Tseng T, Topper M, Thoduvayil S, Radhakrishnan A, Pincet F, Kyriakides T, Gunasekara R, Ramakrishnan S. Photosensitive Nanoprobes for Rapid High Purity Isolation and Size‐Specific Enrichment of Synthetic and Extracellular Vesicle Subpopulations. Advanced Functional Materials 2024, 34 DOI: 10.1002/adfm.202400390.Peer-Reviewed Original ResearchExtracellular vesicle subpopulationsVesicle subpopulationsIsolation of vesiclesPurity extracellular vesiclesRelease of vesiclesAnalysis of nucleic acidsNear-native formLarge-scale isolationLipid nanoprobesDownstream analysisPurity isolationEfficient isolationVesiclesSynthetic vesiclesNucleic acidsExtracellular vesiclesIsolation methodIsolatesBiomarker discoveryExposure to lightSubpopulationsEnrichmentProteinComplex biological mediaCleavage
2015
Conformationally Switchable Water-Soluble Fluorescent Bischolate Foldamers as Membrane-Curvature Sensors
Gunasekara RW, Zhao Y. Conformationally Switchable Water-Soluble Fluorescent Bischolate Foldamers as Membrane-Curvature Sensors. Langmuir 2015, 31: 3919-3925. PMID: 25782344, DOI: 10.1021/acs.langmuir.5b00379.Peer-Reviewed Original ResearchConceptsMembrane curvature sensorMembrane curvatureIonic natureProtein-derived peptidesCellular movementLipid membranesVesicle fusionOnly proteinBiological processesAnionic lipidsΑ-faceSensitive fluorophoreFluorescent labelsFoldamersLipid compositionNBD groupAmount of cholesterolMembraneFluorophoresBuddingProteinSensorsBindingCholateAnalogues