2023
IL-7R licenses a population of epigenetically poised memory CD8+ T cells with superior antitumor efficacy that are critical for melanoma memory
Micevic G, Daniels A, Flem-Karlsen K, Park K, Talty R, McGeary M, Mirza H, Blackburn H, Sefik E, Cheung J, Hornick N, Aizenbud L, Joshi N, Kluger H, Iwasaki A, Bosenberg M, Flavell R. IL-7R licenses a population of epigenetically poised memory CD8+ T cells with superior antitumor efficacy that are critical for melanoma memory. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2304319120. PMID: 37459511, PMCID: PMC10372654, DOI: 10.1073/pnas.2304319120.Peer-Reviewed Original ResearchConceptsIL-7R expressionT cellsIL-7RAntitumor memorySuperior antitumor efficacyCell-based therapiesTumor-specific T cellsAntigen-specific T cellsAntitumor efficacyPowerful antitumor immune responseMarkers of exhaustionTumor-specific CD8Antitumor immune responseIndependent prognostic factorAntitumor immune memoryMemory T cellsMajor risk factorSuperior antitumor activityFunctional CD8Memory CD8Prognostic factorsSurgical resectionAdvanced melanomaLymph nodesNaive miceDiscovery of decreased ferroptosis in male colorectal cancer patients with KRAS mutations
Yan H, Talty R, Jain A, Cai Y, Zheng J, Shen X, Muca E, Paty P, Bosenberg M, Khan S, Johnson C. Discovery of decreased ferroptosis in male colorectal cancer patients with KRAS mutations. Redox Biology 2023, 62: 102699. PMID: 37086630, PMCID: PMC10172914, DOI: 10.1016/j.redox.2023.102699.Peer-Reviewed Original ResearchConceptsKRAS mutant tumorsMale CRC patientsCRC patientsMale patientsKRAS mutationsMutant tumorsOverall survivalMale colorectal cancer patientsKRAS wild-type tumorsAberrant tumor metabolismColorectal cancer patientsCRC patient cohortsColorectal cancer casesFerroptosis-related genesWild-type tumorsNovel potential avenuesNormal colon tissuesPoor OSKRAS statusAdverse outcomesCRC cellsPatient cohortCancer patientsType tumorsCancer casesFerroptosis in colorectal cancer: a future target?
Yan H, Talty R, Aladelokun O, Bosenberg M, Johnson C. Ferroptosis in colorectal cancer: a future target? British Journal Of Cancer 2023, 128: 1439-1451. PMID: 36703079, PMCID: PMC10070248, DOI: 10.1038/s41416-023-02149-6.Peer-Reviewed Original ResearchConceptsColorectal cancerRegulated cell deathCurrent treatment optionsForms of RCDCancer deathTreatment optionsCRC therapyCancer recurrenceTreatment strategiesRadiation therapyOvert toxicityTherapeutic targetDrug resistanceTherapyCancer cellsFerroptosisPotential roleCancerCell deathFuture targetsDeathRecent studiesBiological pathwaysChemotherapySurgery
2022
Targeting ferroptosis to treat colorectal cancer
Yan H, Talty R, Johnson C. Targeting ferroptosis to treat colorectal cancer. Trends In Cell Biology 2022, 33: 185-188. PMID: 36473802, DOI: 10.1016/j.tcb.2022.11.003.Peer-Reviewed Original ResearchConceptsProtein kinase BArachidonic acidColorectal cancer treatmentProtein kinaseKinase BMammalian targetKey pathwaysGlutathione metabolismFerroptosis inductionEnergy metabolismCRC treatmentColorectal cancerCRC pathogenesisFerroptosisCancer treatmentPromising targetNew conceptual avenuesMetabolismTreatmentHippoKinasePrimary strategyRapamycinTargetConceptual avenuesErythrodermic scabies in an immunocompetent patient
Talty R, Micevic G, Damsky W, King BA. Erythrodermic scabies in an immunocompetent patient. JAAD Case Reports 2022, 29: 112-115. PMID: 36262356, PMCID: PMC9573821, DOI: 10.1016/j.jdcr.2022.08.045.Peer-Reviewed Original ResearchSisaipho alopecia areata treated with tofacitinib and oral minoxidil
Talty R, Damsky W, King B. Sisaipho alopecia areata treated with tofacitinib and oral minoxidil. JAAD Case Reports 2022, 29: 41-42. PMID: 36193241, PMCID: PMC9525808, DOI: 10.1016/j.jdcr.2022.08.037.Peer-Reviewed Original ResearchLeukoderma Induced by Rotigotine Patch, a Transdermal Dopamine Agonist
Talty R, Micevic G, Wang A, Ko CJ, Damsky W. Leukoderma Induced by Rotigotine Patch, a Transdermal Dopamine Agonist. Case Reports In Dermatology 2022, 14: 214-218. PMID: 36158852, PMCID: PMC9459519, DOI: 10.1159/000525894.Peer-Reviewed Original ResearchRestless legs syndromeRotigotine patchTransdermal patchRotigotine transdermal patchTransdermal dopamine agonistsPotential side effectsAbsence of melanocytesDopamine agonismSystemic medicationsTopical medicationsDopamine agonistsLegs syndromeCase reportHistopathologic examinationDermal-epidermal junctionAnterior shoulderPharmacologic substancesSide effectsPatch applicationPotential mechanismsLeukodermaMedicationsPatientsSyndromeAgonists
2021
The role of ferroptosis in melanoma
Talty R, Bosenberg M. The role of ferroptosis in melanoma. Pigment Cell & Melanoma Research 2021, 35: 18-25. PMID: 34407291, DOI: 10.1111/pcmr.13009.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitorsNovel therapeutic targetIron-dependent regulated cell deathContext of melanomaRole of ferroptosisDysregulation of ferroptosisForms of cancerCheckpoint inhibitorsAdvanced melanomaImmunotherapy regimensMelanoma patientsTargeted therapyTherapeutic targetSkin cancerMelanomaDeadliest formTherapyRegulated cell deathFerroptosisPatientsCancerCell deathCurrent literatureRegimensRelapseTreatment of cutaneous sarcoidosis with tofacitinib: A case report and review of evidence for Janus kinase inhibition in sarcoidosis
Talty R, Damsky W, King B. Treatment of cutaneous sarcoidosis with tofacitinib: A case report and review of evidence for Janus kinase inhibition in sarcoidosis. JAAD Case Reports 2021, 16: 62-64. PMID: 34522749, PMCID: PMC8427262, DOI: 10.1016/j.jdcr.2021.08.012.Peer-Reviewed Original ResearchModification and application of the proximal humerus ossification system to adolescent idiopathic scoliosis patients
Li DT, Li E, Cui JJ, Kahan JB, Petit L, Adeclat GJ, Modrak M, Talty R, Greene JD, Munger AM, Nicholson AD, Cravez E, Cooperman DR, Smith BG. Modification and application of the proximal humerus ossification system to adolescent idiopathic scoliosis patients. Spine Deformity 2021, 9: 1341-1348. PMID: 33939168, DOI: 10.1007/s43390-021-00338-y.Peer-Reviewed Original ResearchConceptsAdolescent idiopathic scoliosisMedial physisCobb angleSurgical rangeLateral physisStage 3aIdiopathic scoliosisPercentage of patientsIdiopathic scoliosis patientsInter-observer ICCStage 3bInitial presentationPhyseal closureScoliosis patientsHigh riskPatientsSkeletal maturityPhysisHeight velocityRadiographsPeak height velocityProgressionSurgeryHigh rateScoliosisMetabolism of Innate Immune Cells in Cancer
Talty R, Olino K. Metabolism of Innate Immune Cells in Cancer. Cancers 2021, 13: 904. PMID: 33670082, PMCID: PMC7927092, DOI: 10.3390/cancers13040904.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsInnate immune cellsImmune cellsAntitumor immune responseImmune checkpoint blockadeAdoptive cell transferOngoing clinical applicationsSpecific metabolic requirementsInnate immune systemCheckpoint blockadeTumor clearanceAntitumor responseImmune activationMetabolic requirementsT cellsImmune responseEffector functionsImmune systemCell transferTumor microenvironmentCancer cellsPrimary effectorClinical applicationCancerCellsMetabolism
2019
The Proximal Humeral Ossification System Improves Assessment of Maturity in Patients with Scoliosis.
Li DT, Linderman GC, Cui JJ, DeVries S, Nicholson AD, Li E, Petit L, Kahan JB, Talty R, Kluger Y, Cooperman DR, Smith BG. The Proximal Humeral Ossification System Improves Assessment of Maturity in Patients with Scoliosis. Journal Of Bone And Joint Surgery 2019, 101: 1868-1874. PMID: 31626012, PMCID: PMC7515481, DOI: 10.2106/jbjs.19.00296.Peer-Reviewed Original Research
2018
Alterations in synaptic density and myelination in response to exposure to high-energy charged particles.
Dickstein DL, Talty R, Bresnahan E, Varghese M, Perry B, Janssen WGM, Sowa A, Giedzinski E, Apodaca L, Baulch J, Acharya M, Parihar V, Limoli CL. Alterations in synaptic density and myelination in response to exposure to high-energy charged particles. J Comp Neurol 2018, 526: 2845-2855. PMID: 30198564, DOI: 10.1002/cne.24530.Peer-Reviewed Original Research