2008
Novel CYP2C9 Promoter Variants and Assessment of Their Impact on Gene Expression
Kramer M, Rettie A, Rieder M, Cabacungan E, Hines R. Novel CYP2C9 Promoter Variants and Assessment of Their Impact on Gene Expression. Molecular Pharmacology 2008, 73: 1751-1760. PMID: 18310303, PMCID: PMC2413059, DOI: 10.1124/mol.107.044149.Peer-Reviewed Original Research
2007
Ontogeny of human hepatic cytochromes P450
Hines R. Ontogeny of human hepatic cytochromes P450. Journal Of Biochemical And Molecular Toxicology 2007, 21: 169-175. PMID: 17936930, DOI: 10.1002/jbt.20179.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAryl Hydrocarbon HydroxylasesChildChild, PreschoolCytochrome P-450 CYP2C19Cytochrome P-450 CYP2C9Cytochrome P-450 CYP2E1Cytochrome P-450 CYP3ACytochrome P-450 Enzyme SystemGene Expression Regulation, DevelopmentalGene Expression Regulation, EnzymologicHumansInfantLiverMixed Function OxygenasesConceptsHuman hepatic cytochrome P450Adverse drug reactionsConsiderable interindividual variabilityHepatic cytochrome P450Cytochrome P450Human liver samplesImportant endogenous functionsWeeks' gestationThird trimesterFirst trimesterDrug reactionsKey cytochrome P450Postnatal onsetPostnatal increaseTherapeutic efficacyInterindividual variabilityQuantitative Western blottingWestern blottingGestationLow levelsLiver samplesProbe substratesOnset of expressionTrimesterThird group
2003
Developmental Expression of Human Hepatic CYP2C9 and CYP2C19
Koukouritaki S, Manro J, Marsh S, Stevens J, Rettie A, McCarver D, Hines R. Developmental Expression of Human Hepatic CYP2C9 and CYP2C19. Journal Of Pharmacology And Experimental Therapeutics 2003, 308: 965-974. PMID: 14634042, DOI: 10.1124/jpet.103.060137.Peer-Reviewed Original ResearchCYP2C9exon 4 mutations and warfarin dose phenotype in Asians
Rettie A, Tai G, Veenstra D, Farin F, Srinouanprachan S, Lin Y, Thummel K, Hines R. CYP2C9exon 4 mutations and warfarin dose phenotype in Asians. Blood 2003, 101: 2896-2897. PMID: 12642346, DOI: 10.1182/blood-2002-11-3452.Peer-Reviewed Original Research