The ontogeny of drug metabolism enzymes and implications for adverse drug events
Hines R. The ontogeny of drug metabolism enzymes and implications for adverse drug events. Pharmacology & Therapeutics 2008, 118: 250-267. PMID: 18406467, DOI: 10.1016/j.pharmthera.2008.02.005.Peer-Reviewed Original ResearchConceptsAdverse drug eventsDrug eventsDrug metabolism enzymesDME groupPediatric patientsThird trimesterCurrent knowledgeFirst trimesterDrug therapyDrug dispositionPharmacokinetic modelLow levelsEnzyme levelsTrimesterEnzyme expressionGestationSecond groupFetusesMetabolism enzymesBirthPhysiological factorsDevelopmental expression patternsMinimal changesReviewGroupCYP3A4 regulation by DBP and E4BP4 transcription factors
Maas K, Le M, Hines R. CYP3A4 regulation by DBP and E4BP4 transcription factors. The FASEB Journal 2008, 22: 921.7-921.7. DOI: 10.1096/fasebj.22.1_supplement.921.7.Peer-Reviewed Original ResearchD-element binding proteinDose-dependent mannerCYP3A4 promoter activityPromoter activityLuciferase expressionCYP3A4 regulationPostnatal liverLuciferase reporterProtein 4Luciferase activityHepG2 cellsE4BP4Binding proteinDevelopmental expression patternsResponsive elementExpression patternsHigh affinityProximal promoterTranscription factorsExpressionActivity