2012
Hepatobiliary Disposition of 17-OHPC and Taurocholate in Fetal Human Hepatocytes: A Comparison with Adult Human Hepatocytes
Sharma S, Ellis E, Gramignoli R, Dorko K, Tahan V, Hansel M, Mattison D, Caritis S, Hines R, Venkataramanan R, Strom S. Hepatobiliary Disposition of 17-OHPC and Taurocholate in Fetal Human Hepatocytes: A Comparison with Adult Human Hepatocytes. Drug Metabolism And Disposition 2012, 41: 296-304. PMID: 23129211, PMCID: PMC3558857, DOI: 10.1124/dmd.112.044891.Peer-Reviewed Original ResearchMeSH Keywords17 alpha-Hydroxyprogesterone CaproateAdultAge FactorsAgedBiological TransportCells, CulturedCold TemperatureCyclosporineFemaleGestational AgeHepatocytesHumansHydroxyprogesteronesKineticsMaleMembrane Transport ProteinsMiddle AgedMultidrug Resistance-Associated Protein 2RifampinRNA, MessengerTaurocholic AcidVerapamilYoung AdultConceptsHuman hepatocytesFetal human hepatocytesFetal human liverConcentration-dependent inhibitionAdult human hepatocytesBile acid transporterFetal circulationPlacental barrierRecurrent miscarriageSpontaneous abortionProgesterone metabolitesTaurocholate effluxAdult hepatocytesTherapeutic levelsLower mRNA levelsHepatobiliary dispositionHepatic transportersActivity of transportersActive efflux mechanismHuman liverHuman fetalAdverse effectsRole of transportersEfflux mechanismMRNA levels
2006
A Tiered Approach to Life Stages Testing for Agricultural Chemical Safety Assessment
Cooper R, Lamb J, Barlow S, Bentley K, Brady A, Doerrer N, Eisenbrandt D, Fenner-Crisp P, Hines R, Irvine L, Kimmel C, Koeter H, Li A, Makris S, Sheets L, Speijers G, Whitby K. A Tiered Approach to Life Stages Testing for Agricultural Chemical Safety Assessment. Critical Reviews In Toxicology 2006, 36: 69-98. PMID: 16708695, DOI: 10.1080/10408440500541367.Peer-Reviewed Original ResearchConceptsAgricultural Chemical Safety Assessment (ACSA) Technical CommitteeRat reproductionInterpretation of studiesCompound potentialsGuideline studiesAdverse effectsSeverity of effectsHuman exposure potentialEnvironmental Sciences InstituteYoung animalsADME dataILSI HealthTiered approachEndpointExposure durationTask ForceExtent of testingTesting strategiesExposure potentialToxicity informationToxicological endpointsAnimalsChemical safety assessment