2018
High Throughput Validation of Orphan Riboswitch Candidates
Arachchilage G, Sherlock M, White N, Panchapakesan S, Breaker R. High Throughput Validation of Orphan Riboswitch Candidates. The FASEB Journal 2018, 32: lb18-lb18. DOI: 10.1096/fasebj.2018.32.1_supplement.lb18.Peer-Reviewed Original ResearchRiboswitch candidatesRiboswitch classesIntergenic regionCognate ligandsS-adenosylmethionineLong intergenic regionCis-acting genesDiscovery of riboswitchesExperimental Biology 2018 MeetingImportant biological pathwaysHigh-throughput validationHigh-throughput strategyS-adenosylhomocysteineComparative genomicsRecent bioinformaticsBacterial mRNAsLine probingRNA elementsRiboswitchGenetic validationReporter assaysBiological pathwaysComputational approachThroughput strategyFASEB Journal
2010
Riboswitches That Sense Cyclic Di‐GMP
Lee E, Sudarsan N, Breaker R. Riboswitches That Sense Cyclic Di‐GMP. 2010, 215-229. DOI: 10.1128/9781555816667.ch15.Peer-Reviewed Original ResearchGMP riboswitchSecond messengerUntranslated regionCyclic di-GMPHigh sequence conservationAssociation of genesSecond messenger signalingSecondary structure elementsEntire regulonDifferent genetic backgroundsTranscription elongationSequence conservationRNA functionTranslation initiationLine probingDifferent environmental conditionsRiboswitchRegulatory ligandsProtein productsNew hostGenesMessenger RNAGenetic backgroundGreat diversityEnvironmental conditions