Featured Publications
Individualising intensive systolic blood pressure reduction in hypertension using computational trial phenomaps and machine learning: a post-hoc analysis of randomised clinical trials
Oikonomou EK, Spatz ES, Suchard MA, Khera R. Individualising intensive systolic blood pressure reduction in hypertension using computational trial phenomaps and machine learning: a post-hoc analysis of randomised clinical trials. The Lancet Digital Health 2022, 4: e796-e805. PMID: 36307193, PMCID: PMC9768739, DOI: 10.1016/s2589-7500(22)00170-4.Peer-Reviewed Original ResearchConceptsSystolic blood pressure controlBlood pressure controlIntensive systolic blood pressure controlType 2 diabetesPressure controlCardiovascular benefitsClinical trialsMajor adverse cardiovascular eventsFirst major adverse cardiovascular eventLarge randomised clinical trialsACCORD-BP trialAdverse cardiovascular eventsRandomised clinical trialsSystolic blood pressureCox regression analysisTreatment effectsHazard ratio estimatesACCORD-BPBP trialCardiovascular eventsBlood pressurePrimary outcomeStandard treatmentBaseline variablesIndex patients
2018
Impact of 2017 ACC/AHA guidelines on prevalence of hypertension and eligibility for antihypertensive treatment in United States and China: nationally representative cross sectional study
Khera R, Lu Y, Lu J, Saxena A, Nasir K, Jiang L, Krumholz HM. Impact of 2017 ACC/AHA guidelines on prevalence of hypertension and eligibility for antihypertensive treatment in United States and China: nationally representative cross sectional study. The BMJ 2018, 362: k2357. PMID: 29997129, PMCID: PMC6039831, DOI: 10.1136/bmj.k2357.Peer-Reviewed Original ResearchConceptsACC/AHA guidelinesDiagnosis of hypertensionAge groupsHypertension guidelinesAHA guidelinesTreatment patternsCurrent guidelinesACC/AHA hypertension guidelinesHeart Association hypertension guidelinesCurrent treatment patternsIntensification of treatmentPrevalence of hypertensionNutrition Examination SurveyYears age groupUS National HealthYear old adultsSame age groupRetirement Longitudinal StudyAntihypertensive treatmentExamination SurveyNational HealthHypertensionAmerican CollegeChina HealthOlder adultsUsefulness of a Simple Algorithm to Identify Hypertensive Patients Who Benefit from Intensive Blood Pressure Lowering
Wang S, Khera R, Das SR, Vigen R, Wang T, Luo X, Lu R, Zhan X, Xiao G, Vongpatanasin W, Xie Y. Usefulness of a Simple Algorithm to Identify Hypertensive Patients Who Benefit from Intensive Blood Pressure Lowering. The American Journal Of Cardiology 2018, 122: 248-254. PMID: 29880288, DOI: 10.1016/j.amjcard.2018.03.361.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlgorithmsAntihypertensive AgentsBlood PressureFemaleHumansHypertensionMaleMiddle AgedMorbidityRisk AssessmentRisk FactorsTexasConceptsSystolic Blood Pressure Intervention TrialIntensive BP loweringUrinary albumin-creatinine ratioFavorable risk-benefit profileAlbumin-creatinine ratioBP loweringRisk-benefit profileHypertensive patientsBlood pressureMajor adverse cardiovascular event ratesAdverse cardiovascular event ratesIntensive blood pressure loweringMajor adverse cardiovascular eventsRemaining low-risk patientsSimple risk prediction modelIntensive blood pressureStandard BP loweringAdverse cardiovascular eventsBlood pressure loweringSerious adverse eventsCardiovascular event ratesLarge randomized trialsLow-risk patientsSubset of patientsCardiovascular disease risk
2016
Comparative Effectiveness of Pharmacologic Interventions for Pulmonary Arterial Hypertension A Systematic Review and Network Meta-Analysis
Jain S, Khera R, Girotra S, Badesch D, Wang Z, Murad MH, Blevins A, Schmidt GA, Singh S, Gerke AK. Comparative Effectiveness of Pharmacologic Interventions for Pulmonary Arterial Hypertension A Systematic Review and Network Meta-Analysis. CHEST Journal 2016, 151: 90-105. PMID: 27615023, PMCID: PMC5310124, DOI: 10.1016/j.chest.2016.08.1461.Peer-Reviewed Original ResearchMeSH KeywordsAntihypertensive AgentsComparative Effectiveness ResearchHumansHypertension, PulmonaryNetwork Meta-AnalysisConceptsPulmonary arterial hypertensionEndothelin receptor antagonistsArterial hypertensionPharmacologic interventionsFunctional statusNew York Heart Association/World Health Organization functional classWorld Health Organization functional classSystematic reviewFuture comparative-effectiveness trialDiscontinuation of therapyA Systematic ReviewComparative effectiveness trialNetwork Meta-AnalysisPatient-centered approachClinical worseningCochrane RegisterSubcutaneous prostanoidsEfficacy outcomesPlacebo groupPlacebo ratesAdverse eventsReceptor antagonistPharmacologic agentsEffectiveness trialComparative efficacy