2024
A novel digital twin strategy to enable the translation of evidence from randomized control trials to new populations
Thangaraj P, Shankar S, Oikonomou E, Khera R. A novel digital twin strategy to enable the translation of evidence from randomized control trials to new populations. European Heart Journal 2024, 45: ehae666.3502. DOI: 10.1093/eurheartj/ehae666.3502.Peer-Reviewed Original ResearchRandomized clinical trialsPatient populationTranslation of evidenceEffect sizeNon-significant effect sizeRandomized controlled trialsCardiovascular event-free survivalSignificant effect sizeIntensive blood pressure controlEvent-free survivalSPRINT participantsSprintACCORD participantsBlood pressure controlReal-world settingsEffect estimatesControlled trialsMeasured covariatesMedical practiceTreatment effect estimatesCovariate distributionsOriginal trialsACCORD trialCardiovascular eventsClinical trials
2020
Cumulative Burden of Financial Hardship From Medical Bills Across the Spectrum of Diabetes Mellitus and Atherosclerotic Cardiovascular Disease Among Non‐Elderly Adults in the United States
Mszar R, Grandhi GR, Valero‐Elizondo J, Caraballo C, Khera R, Desai N, Virani SS, Blankstein R, Blaha MJ, Nasir K. Cumulative Burden of Financial Hardship From Medical Bills Across the Spectrum of Diabetes Mellitus and Atherosclerotic Cardiovascular Disease Among Non‐Elderly Adults in the United States. Journal Of The American Heart Association 2020, 9: e015523. PMID: 32394783, PMCID: PMC7660844, DOI: 10.1161/jaha.119.015523.Peer-Reviewed Original ResearchConceptsAtherosclerotic cardiovascular diseaseDiabetes mellitusNon-elderly adultsMedical billsCardiovascular diseaseBackground Atherosclerotic cardiovascular diseaseNational Health Interview SurveyEffective public health policiesThird of deathsTreatment-related expensesHealth Interview SurveyHigher relative oddsLogistic regression analysisFinancial hardshipPublic health policyASCVD statusPatient populationStudy populationHigh riskRelative oddsWeighted populationCumulative burdenHealth policyInterview SurveyStrong association
2019
Targeted temperature management for cardiac arrest
Mody P, Kulkarni N, Khera R, Link MS. Targeted temperature management for cardiac arrest. Progress In Cardiovascular Diseases 2019, 62: 272-278. PMID: 31078561, DOI: 10.1016/j.pcad.2019.05.007.Peer-Reviewed Original ResearchConceptsHospital sudden cardiac arrestSudden cardiac arrestTemperature managementCardiac arrestSurvivors of SCAInitial shockable rhythmTargeted temperature managementInitial clinical trialsNon-shockable rhythmCore body temperatureTherapeutic hypothermiaDuration of coolingNeurological functionShockable rhythmPatient populationClinical trialsCurrent guidelinesNeurological damageCurrent evidenceSevere hypoxiaSurvivorsBody temperatureReview articleArrestSignificant improvement