2022
Time in therapeutic range for targeted temperature management and outcomes following out-of-hospital cardiac arrest
Wheelock K, Chan P, Chen L, de Lemos J, Miller P, Nallamothu B, Girotra S, Khera R. Time in therapeutic range for targeted temperature management and outcomes following out-of-hospital cardiac arrest. Resuscitation 2022, 182: 109650. PMID: 36442596, PMCID: PMC9885789, DOI: 10.1016/j.resuscitation.2022.11.016.Peer-Reviewed Original ResearchConceptsFavorable neurologic outcomeHospital cardiac arrestTherapeutic rangeNeurologic outcomeOverall survivalTemperature managementCardiac arrestFavorable neurologic survivalFavorable neurological outcomeRetrospective cohort studyTargeted temperature managementHigh therapeutic rangeRisk-adjusted analysisComatose survivorsNeurologic survivalNeurological outcomeCohort studyHospital dischargeMedian durationMedian timeCurrent guidelinesCompression trialTreatment targetsSignificant associationGoal temperature
2021
Prevalence of Missing Data in the National Cancer Database and Association With Overall Survival
Yang DX, Khera R, Miccio JA, Jairam V, Chang E, Yu JB, Park HS, Krumholz HM, Aneja S. Prevalence of Missing Data in the National Cancer Database and Association With Overall Survival. JAMA Network Open 2021, 4: e211793. PMID: 33755165, PMCID: PMC7988369, DOI: 10.1001/jamanetworkopen.2021.1793.Peer-Reviewed Original ResearchConceptsNational Cancer DatabaseNon-small cell lung cancerOverall survivalCell lung cancerCancer DatabaseMedical recordsLung cancerProstate cancerBreast cancerPatient recordsComplete dataRetrospective cohort studyCohort studyCancer RegistryCommon cancerVariables of interestHigh prevalenceMAIN OUTCOMEPatientsClinical advancementReal-world data sourcesCancerPrevalenceSurvivalHeterogeneous differences
2019
Association Between Hospital Recognition for Resuscitation Guideline Adherence and Rates of Survival for In-Hospital Cardiac Arrest
Khera R, Tang Y, Link MS, Krumholz HM, Girotra S, Chan PS. Association Between Hospital Recognition for Resuscitation Guideline Adherence and Rates of Survival for In-Hospital Cardiac Arrest. Circulation Cardiovascular Quality And Outcomes 2019, 12: e005429. PMID: 30871337, PMCID: PMC6592630, DOI: 10.1161/circoutcomes.118.005429.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAwards and PrizesFemaleGuideline AdherenceHeart ArrestHospital MortalityHospitalsHumansInpatientsMaleMiddle AgedOutcome and Process Assessment, Health CarePatient DischargePractice Guidelines as TopicPractice Patterns, Physicians'Quality Indicators, Health CareRegistriesResuscitationTime FactorsTime-to-TreatmentTreatment OutcomeUnited StatesYoung AdultConceptsHospital cardiac arrestCardiac arrestRate of survivalSpontaneous circulationIn-Hospital Cardiac ArrestGuidelines-Resuscitation registryCardiac arrest survivalEndotracheal tube placementHigh rateHospital performanceBest tertileGuidelines-ResuscitationNational GetGuideline adherenceOverall survivalBackground HospitalTube placementNational registryChest compressionsResuscitation qualityHospitalHospital recognitionAward statusSurvivalWeak association
2016
Hospital Variation in Time to Epinephrine for Nonshockable In-Hospital Cardiac Arrest
Khera R, Chan PS, Donnino M, Girotra S. Hospital Variation in Time to Epinephrine for Nonshockable In-Hospital Cardiac Arrest. Circulation 2016, 134: 2105-2114. PMID: 27908910, PMCID: PMC5173427, DOI: 10.1161/circulationaha.116.025459.Peer-Reviewed Original ResearchConceptsHospital cardiac arrestEpinephrine administrationCardiac arrestFunctional recoveryHospital variationNonshockable rhythmsHospital ratesSurvival rateRisk-standardized survival ratesIn-Hospital Cardiac ArrestHospital-level outcomesRisk-standardized ratesDose of epinephrineMedian survival rateOdds of delayHigh rateGuidelines-ResuscitationAdult patientsOverall survivalWorse survivalSimilar patientsLowest quartileImproved outcomesHospitalPatients
2009
Diffuse large B-cell lymphoma: experience from a tertiary care center in north India
Khera R, Jain S, Kumar L, Thulkar S, Vijayraghwan M, Dawar R. Diffuse large B-cell lymphoma: experience from a tertiary care center in north India. Medical Oncology 2009, 27: 310-318. PMID: 19350421, DOI: 10.1007/s12032-009-9211-2.Peer-Reviewed Original ResearchConceptsDiffuse large B-cell lymphomaB symptomsAnn Arbor stage IV diseaseRetrospective case record studyMedian event-free survivalLarge B-cell lymphomaClinico-laboratory characteristicsMedian overall survivalUnfavorable prognosis groupStage IV diseaseEvent-free survivalSerum albumin levelTertiary care centerClinico-pathological presentationErythrocyte sedimentation rateCase record studyB-cell lymphomaFree survivalAlbumin levelsMedian ageOverall survivalPatient characteristicsPrognostic factorsHemoglobin levelsPrognosis group