2024
A novel digital twin strategy to enable the translation of evidence from randomized control trials to new populations
Thangaraj P, Shankar S, Oikonomou E, Khera R. A novel digital twin strategy to enable the translation of evidence from randomized control trials to new populations. European Heart Journal 2024, 45: ehae666.3502. DOI: 10.1093/eurheartj/ehae666.3502.Peer-Reviewed Original ResearchRandomized clinical trialsPatient populationTranslation of evidenceEffect sizeNon-significant effect sizeRandomized controlled trialsCardiovascular event-free survivalSignificant effect sizeIntensive blood pressure controlEvent-free survivalSPRINT participantsSprintACCORD participantsBlood pressure controlReal-world settingsEffect estimatesControlled trialsMeasured covariatesMedical practiceTreatment effect estimatesCovariate distributionsOriginal trialsACCORD trialCardiovascular eventsClinical trials
2009
Diffuse large B-cell lymphoma: experience from a tertiary care center in north India
Khera R, Jain S, Kumar L, Thulkar S, Vijayraghwan M, Dawar R. Diffuse large B-cell lymphoma: experience from a tertiary care center in north India. Medical Oncology 2009, 27: 310-318. PMID: 19350421, DOI: 10.1007/s12032-009-9211-2.Peer-Reviewed Original ResearchConceptsDiffuse large B-cell lymphomaB symptomsAnn Arbor stage IV diseaseRetrospective case record studyMedian event-free survivalLarge B-cell lymphomaClinico-laboratory characteristicsMedian overall survivalUnfavorable prognosis groupStage IV diseaseEvent-free survivalSerum albumin levelTertiary care centerClinico-pathological presentationErythrocyte sedimentation rateCase record studyB-cell lymphomaFree survivalAlbumin levelsMedian ageOverall survivalPatient characteristicsPrognostic factorsHemoglobin levelsPrognosis group