2024
Development and multinational validation of an algorithmic strategy for high Lp(a) screening
Aminorroaya A, Dhingra L, Oikonomou E, Saadatagah S, Thangaraj P, Vasisht Shankar S, Spatz E, Khera R. Development and multinational validation of an algorithmic strategy for high Lp(a) screening. Nature Cardiovascular Research 2024, 3: 558-566. PMID: 39195936, DOI: 10.1038/s44161-024-00469-1.Peer-Reviewed Original ResearchElectronic health recordsAssociated with premature atherosclerotic cardiovascular diseaseElevated Lp(aHealth recordsUK BiobankPremature atherosclerotic cardiovascular diseaseMachine learning modelsAtherosclerotic cardiovascular diseaseCohort studyReal-world settingsTargeted screeningCardiovascular diseaseLearning modelsNovel targeted therapeuticsAlgorithmic strategiesCohortProbability thresholdScreeningClinical featuresValidation cohortElevated lipoproteinRisk inspectionARICLp(a
2015
Role of D-dimer Assays in the Diagnostic Evaluation of Pulmonary Embolism
Jain S, Khera R, Suneja M, Gehlbach B, Kuperman E, Lopez F. Role of D-dimer Assays in the Diagnostic Evaluation of Pulmonary Embolism. The American Journal Of The Medical Sciences 2015, 350: 501-507. PMID: 25719981, DOI: 10.1097/maj.0000000000000405.Peer-Reviewed Original ResearchConceptsDiagnosis of PEPulmonary embolismClinical featuresD-dimerDiagnostic algorithmPositive D-dimer testNonspecific clinical featuresSimple noninvasive testD-dimer testD-dimer assayClinician suspicionInitial imagingAlternative diagnosesElderly menNoninvasive testsClinical algorithmDiagnostic evaluationChest imagingDiagnosisEmbolismLittle valueImagingComorbiditiesPneumoniaPatients