1991
Muscarinic receptors in diabetic rat prostate
Latifpour J, Gousse A, Yoshida M, Weiss R. Muscarinic receptors in diabetic rat prostate. Biochemical Pharmacology 1991, 42: s113-s119. PMID: 1768268, DOI: 10.1016/0006-2952(91)90400-y.Peer-Reviewed Original ResearchConceptsMuscarinic receptorsRat prostateM3 muscarinic receptor subtypesMembrane particulatesAF-DX 116Injection of streptozotocinMuscarinic cholinergic receptorsMuscarinic receptor subtypesSTZ-induced diabetesM3 muscarinic receptorsDiabetic rat prostateLower body weightGroups of ratsInsulin-treated animalsVariety of abnormalitiesDiabetic insulinMuscarinic antagonistSmaller prostatesCholinergic receptorsReceptor subtypesPharmacological profileBody weightFmol/Myo-inositolDiabetesDifferential regulation of bladder beta-adrenergic and muscarinic cholinergic receptors in experimental diabetes
Latifpour J, Nishimoto T, Marian M, Yoshida M, Weiss R. Differential regulation of bladder beta-adrenergic and muscarinic cholinergic receptors in experimental diabetes. Diabetes 1991, 40: 1150-1156. DOI: 10.2337/diabetes.40.9.1150.Peer-Reviewed Original ResearchDifferential Regulation of Bladder β-Adrenergic and Muscarinic Cholinergic Receptors in Experimental Diabetes
Latifpour J, Nishimoto T, Marian M, Yoshida M, Weiss R. Differential Regulation of Bladder β-Adrenergic and Muscarinic Cholinergic Receptors in Experimental Diabetes. Diabetes 1991, 40: 1150-1156. PMID: 1657672, DOI: 10.2337/diab.40.9.1150.Peer-Reviewed Original ResearchConceptsBeta-adrenergic receptorsSucrose-fed ratsBladder domeDetrusor stripsDiabetic ratsHigher serum glucose levelsLower serum insulin levelsLarger contractile responsesMuscarinic receptor upregulationHigher urine outputCarbachol-induced contractionDiabetes-induced alterationsMuscarinic cholinergic receptorsSerum insulin levelsSTZ-induced diabetesSerum glucose levelsIsoproterenol-induced relaxationAge-matched controlsLower body weightSucrose-fed animalsBladder hypertrophyContractile responseDiabetic bladderUrine outputRelaxed KClBeta adrenergic receptor alterations in diabetic rat prostate: Effects of insulin and dietary myoinositol
Gousse A, Yoshida M, Weiss R, Latifpour J. Beta adrenergic receptor alterations in diabetic rat prostate: Effects of insulin and dietary myoinositol. The Prostate 1991, 19: 121-131. PMID: 1681523, DOI: 10.1002/pros.2990190205.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAnimalsBlood GlucoseBody WeightDiabetes Mellitus, ExperimentalDihydroalprenololDose-Response Relationship, DrugDrinkingInositolInsulinIsoproterenolMaleOrgan SizePropanolaminesPropranololProstateRadioligand AssayRatsRats, Inbred StrainsReceptors, Adrenergic, betaStreptozocinUrinationConceptsBeta-adrenergic receptorsAdrenergic receptorsInsulin levelsRadioligand receptor binding techniquesSelective beta-adrenergic antagonistsHigh blood glucose levelsLower serum insulin levelsAdrenergic receptor alterationsInduction of diabetesInsulin-treated diabeticsSerum insulin levelsBeta-adrenergic receptor alterationsAutonomic nervous systemBlood glucose levelsBeta-adrenergic antagonistsDiabetic rat prostateGroups of ratsReceptor binding techniquesEffect of insulinMale reproductive systemHigh water intakeDietary myoinositolDiabetes mellitusUrine outputDiabetic rats
1990
Autonomic receptors in urinary tract: sex and age differences.
Latifpour J, Kondo S, O'Hollaren B, Morita T, Weiss R. Autonomic receptors in urinary tract: sex and age differences. Journal Of Pharmacology And Experimental Therapeutics 1990, 253: 661-7. PMID: 2338651.Peer-Reviewed Original ResearchConceptsAlpha-2 adrenergic receptorsBladder domeBladder baseBeta-adrenergic receptorsAdrenergic receptorsCholinergic receptorsMuscarinic receptorsUrinary tractAlpha-2 adrenergic receptor densityLower urinary tract smooth muscleUrinary tract smooth muscleRabbit bladder baseAlpha 2A subtypeMuscarinic cholinergic receptorsAdrenergic receptor densityLower urinary tractSelective adrenergic agonistsAdult rat cortexNeonatal rat lungBeta-2 adrenergic receptorsAutonomic receptorsAge-related differencesRat cortexAdrenergic agonistsMale urethra
1989
Effects of experimental diabetes on biochemical and functional characteristics of bladder muscarinic receptors.
Latifpour J, Gousse A, Kondo S, Morita T, Weiss R. Effects of experimental diabetes on biochemical and functional characteristics of bladder muscarinic receptors. Journal Of Pharmacology And Experimental Therapeutics 1989, 248: 81-8. PMID: 2913290.Peer-Reviewed Original ResearchConceptsMuscarinic receptorsBladder domeDiabetic animalsMuscarinic agonistsExperimental diabetesRat bladder smooth muscleED50 valuesHigher serum glucose levelsBladder muscarinic receptorsLarger contractile responsesMuscarinic receptor propertiesAF-DX 116Serum insulin levelsSerum glucose levelsBladder smooth muscleM2 muscarinic receptorsAge-matched controlsLower body weightReceptor binding studiesBladder dysfunctionContractile responseCommon complicationDiabetes mellitusPeripheral neuropathyUrine output