1995
Malignant and Normal T Cells Show Random Use of T-Cell Receptor ∝ Chain Variable Regions in Patients with Cutaneous T-Cell Lymphoma
Longley J, Tyrrell L, Lu S, Farrell J, Ding T, Yan S, Sallee D, Heald P, Berger C, Tigelaar R, Edelson R. Malignant and Normal T Cells Show Random Use of T-Cell Receptor ∝ Chain Variable Regions in Patients with Cutaneous T-Cell Lymphoma. Journal Of Investigative Dermatology 1995, 105: 62-64. PMID: 7615977, DOI: 10.1111/1523-1747.ep12312571.Peer-Reviewed Original ResearchConceptsCutaneous T-cell lymphomaT-cell lymphomaT cell receptorMalignant cellsRegion usagePathogenesis of CTCLNormal peripheral blood lymphocytesV region usagePeripheral blood lymphocytesNormal T cellsTCR V regionsMature T lymphocytesBeta-chain transcriptsBeta usageChain transcriptsOligoclonal patternAlpha usePeripheral bloodLeukemic patientsPolymerase chain reactionBlood lymphocytesChronic stimulationMalignant lymphocytesT cellsT lymphocytes
1993
THE TREATMENT OF MASTOCYTOMA CELLS WITH 8‐METHOXYPSORALEN AND LONG‐WAVELENGTH ULTRAVIOLET RADIATION ENHANCES CELLULAR IMMUNOGENICITY: PRELIMINARY RESULTS
Gasparro F, Malane M, Maxwell V, Tigelaar R. THE TREATMENT OF MASTOCYTOMA CELLS WITH 8‐METHOXYPSORALEN AND LONG‐WAVELENGTH ULTRAVIOLET RADIATION ENHANCES CELLULAR IMMUNOGENICITY: PRELIMINARY RESULTS. Photochemistry And Photobiology 1993, 58: 682-688. PMID: 8284324, DOI: 10.1111/j.1751-1097.1993.tb04952.x.Peer-Reviewed Original ResearchConceptsCutaneous T-cell lymphomaLong-wavelength ultraviolet radiationT-cell lymphomaMurine immune systemP1 cellsNew surface antigensCellular immunogenicityImmunized miceUVA photochemotherapyImmunosuppressed miceImmune cellsDBA/2 miceCell lymphomaSurface antigenImmune systemSignificant protectionPilot studyMiceImmunogenicityMastocytoma cellsN-methyl-N'UVA treatmentUltraviolet radiationTreatmentAntigenSkin-Selective Lymphocyte Homing Mechanisms in the Pathogenesis of Leukemic Cutaneous T-Cell Lymphoma
Heald P, Yan S, Edelson R, Tigelaar R, Picker L. Skin-Selective Lymphocyte Homing Mechanisms in the Pathogenesis of Leukemic Cutaneous T-Cell Lymphoma. Journal Of Investigative Dermatology 1993, 101: 222-226. PMID: 7688404, DOI: 10.1111/1523-1747.ep12364814.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAntigens, Differentiation, T-LymphocyteAntigens, NeoplasmCell Adhesion MoleculesEpitopesE-SelectinHumansLeukemia-Lymphoma, Adult T-CellLeukocyte Common AntigensLymphoma, T-Cell, CutaneousMembrane GlycoproteinsReceptors, Antigen, T-CellReceptors, Lymphocyte HomingSkin NeoplasmsT-LymphocytesConceptsCutaneous T-cell lymphomaT-cell lymphomaCutaneous lymphocyte antigenLymphocyte antigenT cellsErythrodermic cutaneous T-cell lymphomaLeukemic cutaneous T-cell lymphomaCutaneous T-cell lymphoma patientsSkin-associated lymphoid tissueT-cell lymphoma patientsTwo-color flow cytometryCutaneous host defenseT cells trafficMemory T cellsT cell subsetsCell surface phenotypeErythrodermic patientsLymphoma patientsPatient groupInflamed skinLymphoid tissueHoming receptorMalignant cloneLymphomaMalignant cells
1984
The Intracutaneous Growth of Murine Lymphomas: Epidermal Invasion Is Characteristic of Multiple Tumor Phenotypes
Piepkorn M, Tigelaar R. The Intracutaneous Growth of Murine Lymphomas: Epidermal Invasion Is Characteristic of Multiple Tumor Phenotypes. Journal Of Investigative Dermatology 1984, 83: 281-285. PMID: 6237158, DOI: 10.1111/1523-1747.ep12340368.Peer-Reviewed Original ResearchConceptsMycosis fungoidesT cellsHelper/inducer T cellsCutaneous T-cell lymphomaT cell surface phenotypeInducer T cellsBALB/c originT-cell lymphomaMalignant T cellsLymphoid cell subsetsEosin-stained sectionsCenter of tumorT cell linesCytotoxic markersSézary syndromeCell subsetsBenign dermatosesDermal-epidermal junctionEpidermal necrosisParallel groupIntradermal injectionT lymphocytesSyngeneic miceSurface phenotypeLymphoid cells
1983
Thy-1 Antigen-Bearing Dendritic Cells Populate Murine Epidermis
Bergstresser P, Tigelaar R, Dees J, Streilein J. Thy-1 Antigen-Bearing Dendritic Cells Populate Murine Epidermis. Journal Of Investigative Dermatology 1983, 81: 286-288. PMID: 6136547, DOI: 10.1111/1523-1747.ep12518332.Peer-Reviewed Original ResearchConceptsLangerhans cellsMurine epidermisCutaneous T-cell lymphomaEar epidermisDendritic cell populationsStrain BALB/cT-cell lymphomaEpidermal Langerhans cellsThy-1.2 antigenBALB/cCell populationsThy-1 antigenT lymphocytesIa antigensDistinct cell populationsMalignant counterpartsThy-1Monoclonal antibodiesStrain B10.AAntigenMelanocytesImmunofluorescence microscopySkin surfaceEpidermisMature melanocytes