2014
Confluence of Depression and Acute Psychological Stress Among Patients With Stable Coronary Heart Disease: Effects on Myocardial Perfusion
Burg MM, Meadows J, Shimbo D, Davidson KW, Schwartz JE, Soufer R. Confluence of Depression and Acute Psychological Stress Among Patients With Stable Coronary Heart Disease: Effects on Myocardial Perfusion. Journal Of The American Heart Association 2014, 3: e000898. PMID: 25359402, PMCID: PMC4338683, DOI: 10.1161/jaha.114.000898.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedChi-Square DistributionChronic DiseaseConnecticutCoronary CirculationCoronary DiseaseDepressionFemaleHemodynamicsHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisMyocardial Perfusion ImagingOdds RatioPredictive Value of TestsPsychiatric Status Rating ScalesRecurrenceRisk FactorsSeverity of Illness IndexStress, PsychologicalTomography, Emission-Computed, Single-PhotonConceptsAcute psychological stressMyocardial perfusionPsychological stressDepressed rangeNormal rangeAcute coronary syndrome (ACS) recurrenceSelective serotonin reuptake inhibitor medicationsStable coronary heart diseaseCoronary heart disease patientsSerotonin reuptake inhibitor medicationsImpaired myocardial perfusionTomography myocardial perfusionCoronary heart diseaseMortality risk factorsOptimal medical careHigh normal rangeReuptake inhibitor medicationsHeart disease patientsBeck Depression InventorySingle photon emissionACS recurrenceCHD prognosisInhibitor medicationVascular mechanismsMeasures of depression
2013
Therapy for Mental Stress–Induced Myocardial Ischemia
Burg MM, Soufer R. Therapy for Mental Stress–Induced Myocardial Ischemia. JAMA 2013, 310: 1400-1401. PMID: 24084926, DOI: 10.1001/jama.2013.277951.Peer-Reviewed Original Research
2010
Tendency to Angry Rumination Predicts Stress-Provoked Endothelin-1 Increase in Patients With Coronary Artery Disease
Fernandez AB, Soufer R, Collins D, Soufer A, Ranjbaran H, Burg MM. Tendency to Angry Rumination Predicts Stress-Provoked Endothelin-1 Increase in Patients With Coronary Artery Disease. Psychosomatic Medicine 2010, 72: 348-353. PMID: 20368479, PMCID: PMC2872076, DOI: 10.1097/psy.0b013e3181d71982.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseET-1 increaseET-1Chronic stable coronary heart diseaseStable coronary heart diseaseMultivariate logistic regression modelET-1 elevationAcute coronary syndromeHistory of diabetesRate-pressure productCoronary artery diseaseEndothelin-1 increaseLogistic regression modelsCoronary syndromeArtery diseaseBeta blockersPotential confoundersPressure productHeart diseasePlaque ruptureBlood samplesPatientsAngry ruminationNitric oxideStress protocol
2008
Noninvasive Detection of Risk for Emotion Provoked Myocardial Ischemia
Burg MM, Graeber B, Vashist A, Collins D, Earley C, Liu J, Lampert R, Soufer R. Noninvasive Detection of Risk for Emotion Provoked Myocardial Ischemia. Psychosomatic Medicine 2008, 71: 14-20. PMID: 18941131, PMCID: PMC2739989, DOI: 10.1097/psy.0b013e318187c035.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngerAngiotensin-Converting Enzyme InhibitorsBlood PressureCoronary DiseaseEpinephrineFemaleHeart RateHumansImagery, PsychotherapyMaleManometryMiddle AgedMyocardial IschemiaNorepinephrinePlethysmographyPredictive Value of TestsPulsatile FlowRiskSensitivity and SpecificityStress, PsychologicalTomography, Emission-Computed, Single-PhotonVascular ResistanceConceptsPeripheral arterial tonometryCoronary artery diseasePAT ratioMyocardial ischemiaMajor adverse cardiac eventsStable coronary artery diseaseLower PAT ratioMental stress ischemiaAdverse cardiac eventsNew perfusion defectsCT myocardial perfusionSensitivity/specificityStress ischemiaArterial tonometryCardiac eventsArtery diseaseBlood pressureACE inhibitionPerfusion defectsHeart rateMyocardial perfusionPatientsEnzyme inhibitorsClinical settingIschemia
2006
C-Reactive Protein and Vulnerability to Mental Stress-Induced Myocardial Ischemia
Shah R, Burg MM, Vashist A, Collins D, Liu J, Jadbabaie F, Graeber B, Earley C, Lampert R, Soufer R. C-Reactive Protein and Vulnerability to Mental Stress-Induced Myocardial Ischemia. Molecular Medicine 2006, 12: 269-274. PMID: 17380191, PMCID: PMC1829194, DOI: 10.2119/2006-00077.shah.Peer-Reviewed Original ResearchConceptsC-reactive proteinCoronary artery diseaseMyocardial perfusion imagingTransthoracic echocardiographyCRP levelsMental stressRisk markersMyocardial ischemiaLevels of CRPNew regional wall motion abnormalitiesAssociation of CRPRelationship of CRPSimultaneous single-photon emissionStable coronary artery diseaseUnivariate logistic regression analysisRegional wall motion abnormalitiesTetrofosmin myocardial perfusion imagingLaboratory mental stressRisk of MSISerum CRP levelsHistory of diabetesSubsequent clinical eventsNew perfusion defectsWall motion abnormalitiesLogistic regression analysis
2004
Neurocardiac Interaction During Stress-Induced Myocardial Ischemia
Soufer R. Neurocardiac Interaction During Stress-Induced Myocardial Ischemia. Circulation 2004, 110: 1710-1713. PMID: 15451806, DOI: 10.1161/01.cir.0000144841.84987.50.Peer-Reviewed Original Research
2003
Simultaneous assessment of myocardial perfusion and function during mental stress in patients with chronic coronary artery disease
Arrighi JA, Burg M, Cohen IS, Soufer R. Simultaneous assessment of myocardial perfusion and function during mental stress in patients with chronic coronary artery disease. Journal Of Nuclear Cardiology 2003, 10: 267-274. PMID: 12794625, DOI: 10.1016/s1071-3581(02)43235-7.Peer-Reviewed Original ResearchConceptsMyocardial perfusion imagingChronic coronary artery diseaseLeft ventricular dysfunctionVentricular dysfunctionCoronary artery diseaseReversible perfusion defectsPerfusion defectsArtery diseaseVentricular functionMyocardial perfusionNew regional wall motion abnormalitiesSestamibi single-photon emissionPharmacologic stress myocardial perfusion imagingStress myocardial perfusion imagingGlobal left ventricular dysfunctionRegional wall motion abnormalitiesResultsTwenty-eight patientsLeft ventricular functionWall motion abnormalitiesTomography (SPECT) MPIMyocardial perfusion defectsRegional wall motionCircumferential profile analysisSingle photon emissionSimultaneous assessmentPresurgical Depression Predicts Medical Morbidity 6 Months After Coronary Artery Bypass Graft Surgery
Burg MM, Benedetto MC, Rosenberg R, Soufer R. Presurgical Depression Predicts Medical Morbidity 6 Months After Coronary Artery Bypass Graft Surgery. Psychosomatic Medicine 2003, 65: 111-118. PMID: 12554822, DOI: 10.1097/01.psy.0000038940.33335.09.Peer-Reviewed Original ResearchConceptsCoronary artery bypass graft surgeryArtery bypass graft surgeryBypass graft surgeryPresurgical depressionBeck Depression InventoryGraft surgeryDepression IndexMedical outcomesDepression InventoryShort-term medical outcomesPsychosocial risk indexCoronary artery diseasePoor medical prognosisImpact of depressionPsychosocial risk factorsOutcomes of interestQuality of lifeImportant independent contributorCardiac hospitalizationArtery diseaseSurgical painPsychosocial morbidityMedical recordsRisk factorsStudy population
2000
Myocardial blood-flow response during mental stress in patients with coronary artery disease
Arrighi J, Burg M, Cohen I, Kao A, Pfau S, Caulin-Glaser T, Zaret B, Soufer R. Myocardial blood-flow response during mental stress in patients with coronary artery disease. The Lancet 2000, 356: 310-311. PMID: 11071190, DOI: 10.1016/s0140-6736(00)02510-1.Peer-Reviewed Original ResearchPersistent Changes in Myocardial Glucose Metabolism In Vivo During Reperfusion of a Limited-Duration Coronary Occlusion
McNulty P, Jagasia D, Cline G, Ng C, Whiting J, Garg P, Shulman G, Soufer R. Persistent Changes in Myocardial Glucose Metabolism In Vivo During Reperfusion of a Limited-Duration Coronary Occlusion. Circulation 2000, 101: 917-922. PMID: 10694532, DOI: 10.1161/01.cir.101.8.917.Peer-Reviewed Original ResearchConceptsCoronary occlusionGlucose metabolismPostischemic stunningAnterolateral left ventricleHeart glucose metabolismCoronary artery occlusionRegional glucose metabolismMyocardial glucose metabolismRegional myocardial ischemiaRegional mechanical functionRapid reperfusionReversible coronary occlusionArtery occlusionMyocardial ischemiaIntact ratsPreferential shuntingBlood flowReperfusionTracer uptakeLeft ventricleGlycogen depletionMetabolic signaturesOcclusionPersistent changesSustained changes
1998
Myocardial viability: Seeking relevance and redefinition
Arrighi J, Soufer R. Myocardial viability: Seeking relevance and redefinition. Journal Of Nuclear Cardiology 1998, 5: 629-633. PMID: 9869486, DOI: 10.1016/s1071-3581(98)90118-0.Peer-Reviewed Original ResearchCerebral cortical hyperactivation in response to mental stress in patients with coronary artery disease
Soufer R, Bremner J, Arrighi J, Cohen I, Zaret B, Burg M, Goldman-Rakic P. Cerebral cortical hyperactivation in response to mental stress in patients with coronary artery disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 6454-6459. PMID: 9600987, PMCID: PMC27794, DOI: 10.1073/pnas.95.11.6454.Peer-Reviewed Original ResearchMeSH KeywordsAdultCerebral CortexCoronary DiseaseEchocardiographyHeart RateHumansMagnetic Resonance ImagingMaleStress, PsychologicalConceptsCoronary artery diseaseVisual association cortexSuperior frontal gyrusRight visual association cortexCAD patientsHealthy subjectsPositron emission tomographyMental stressAssociation cortexFrontal gyrusArtery diseaseMyocardial ischemiaAnterior cingulateCentral nervous system effectsCAD patient groupCerebral cortical responsePainless myocardial ischemiaNervous system effectsLeft parietal cortexInferior parietal lobuleMiddle temporal gyrusPatient groupSerial subtraction taskRight thalamusInferior frontal gyrusEffects of Mental Stress on Left Ventricular and Peripheral Vascular Performance in Patients With Coronary Artery Disease
Jain D, Shaker M, Burg M, Wackers F, Soufer R, Zaret B. Effects of Mental Stress on Left Ventricular and Peripheral Vascular Performance in Patients With Coronary Artery Disease. Journal Of The American College Of Cardiology 1998, 31: 1314-1322. PMID: 9581726, DOI: 10.1016/s0735-1097(98)00092-8.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionPeripheral vascular resistanceCoronary artery diseaseRate-pressure productStress-induced fallSystolic blood pressureArtery diseaseBlood pressureCardiac outputHeart rateMental stressGroup IHemodynamic variablesAnger recallGroup IIMental stressorsEnd-systolic ventricular elastanceMental stress-induced changesSemisupine bicycle exerciseGroup II patientsComparable increaseDiastolic blood pressureVentricular ejection fractionExercise-induced changesVascular resistanceReverse redistribution: Is it clinically relevant or a washout?
Arrighi J, Soufer R. Reverse redistribution: Is it clinically relevant or a washout? Journal Of Nuclear Cardiology 1998, 5: 195-201. PMID: 9588671, DOI: 10.1016/s1071-3581(98)90202-1.Peer-Reviewed Original Research
1995
Left ventricular diastolic function: Physiology, methods of assessment, and clinical significance
Arrighi J, Soufer R. Left ventricular diastolic function: Physiology, methods of assessment, and clinical significance. Journal Of Nuclear Cardiology 1995, 2: 525-543. PMID: 9420835, DOI: 10.1016/s1071-3581(05)80045-5.Peer-Reviewed Original ResearchConceptsDiastolic functionVentricular fillingHeart failureElevated pulmonary venous pressureNormal systolic ventricular functionSystolic ventricular functionNormal systolic functionCongestive heart failurePulmonary venous pressureCoronary artery diseaseCalcium channel blockersEarly ventricular fillingHealthy elderly subjectsMitral valve closureBeta blockersSystolic functionArtery diseaseCardiac catheterizationSuch patientsValvular diseaseVenous pressureVentricular functionOptimal therapyRadionuclide angiographyMyocardial complianceComparison of sestamibi single-photon emission computed tomography with positron emission tomography for estimating left ventricular myocarclial viability
Soufer R, Dey H, Ng C, Zaret B. Comparison of sestamibi single-photon emission computed tomography with positron emission tomography for estimating left ventricular myocarclial viability. The American Journal Of Cardiology 1995, 75: 1214-1219. PMID: 7778542, DOI: 10.1016/s0002-9149(99)80765-6.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCoronary DiseaseDeoxyglucoseFluorine RadioisotopesFluorodeoxyglucose F18HumansMaleMiddle AgedMyocardial ContractionRadionuclide VentriculographyStroke VolumeTechnetium Tc 99m SestamibiTomography, Emission-ComputedTomography, Emission-Computed, Single-PhotonVentricular Function, LeftConceptsPositron emission tomographySestamibi single-photon emissionSingle photon emissionCoronary artery diseaseMyocardial viabilityInferior wallArtery diseaseEmission tomographyFDG positron emission tomographySubset of patientsRegional ejection fractionDiscordant segmentsNonviable segmentsEjection fractionMethoxyisobutyl isonitrileRadionuclide ventriculographySestamibi protocolBlood flowMyocardial segmentsPatientsViable segmentsFluorodeoxyglucoseMIBITomographyDiseaseReverse redistribution on planar thallium scintigraphy: relationship to resting thallium uptake and long-term outcome
Dey H, Soufer R. Reverse redistribution on planar thallium scintigraphy: relationship to resting thallium uptake and long-term outcome. European Journal Of Nuclear Medicine And Molecular Imaging 1995, 22: 237-242. PMID: 7789397, DOI: 10.1007/bf01081519.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseChronic coronary artery diseasePatient outcomesLogistic multiple regression analysisRR segmentsPlanar thallium scintigraphyLong-term outcomesRecent thrombolysisThallium reinjectionArtery diseaseThallium scintigraphyIndependent predictorsScintigraphic findingsPrognostic significanceMyocardial infarctionRedistribution imagesThallium uptakeThallium-201Physiologic basisScarred myocardiumMultiple regression analysisRegression analysisOutcomesThrombolysisInfarctionRelationship between reverse redistribution on planar thallium scintigraphy and regional myocardial viability: a correlative PET study.
Soufer R, Dey H, Lawson A, Wackers F, Zaret B. Relationship between reverse redistribution on planar thallium scintigraphy and regional myocardial viability: a correlative PET study. Journal Of Nuclear Medicine 1995, 36: 180-7. PMID: 7830110.Peer-Reviewed Original ResearchConceptsPlanar thallium scintigraphyCardiac eventsThallium scintigraphyReverse redistributionChronic coronary artery diseasePET viabilityAbnormal regional wall motionPlanar thallium imagesMyocardial Infarction trialPercent of patientsFuture cardiac eventsFuture cardiovascular eventsCoronary artery diseaseFavorable clinical outcomeMyocardial metabolic activityRegional wall motion analysisRegional wall motionPercent of segmentsWall motion analysisPET criteriaCardiovascular eventsReperfusion therapyArtery diseaseClinical outcomesPrognostic value
1993
Role of behavioral and psychological factors in mental stress-induced silent left ventricular dysfunction in coronary artery disease
Burg M, Jain D, Soufer R, Kerns R, Zaret B. Role of behavioral and psychological factors in mental stress-induced silent left ventricular dysfunction in coronary artery disease. Journal Of The American College Of Cardiology 1993, 22: 440-448. PMID: 8335813, DOI: 10.1016/0735-1097(93)90048-6.Peer-Reviewed Original ResearchConceptsSilent left ventricular dysfunctionLeft ventricular dysfunctionCoronary artery diseaseVentricular dysfunctionArtery diseaseBlood pressureChronic stable coronary artery diseaseStable coronary artery diseaseStress thallium-201 imagingMental stressGroup I patientsSilent myocardial ischemiaThallium-201 imagingAbsence of symptomsSerial radionuclide ventriculographyStructured interviewsNonischemic groupEjection fractionI patientsPsychological factorsVentricular indexRadionuclide ventriculographyClinical indicesMyocardial ischemiaReversible defects
1992
Left Ventricular Diastolic Function during Positive End-expiratory Pressure: Impact of Right Ventricular Ischemia and Ventricular Interaction
Schulman D, Biondi J, Zohgbi S, Cecchetti A, Zaret B, Soufer R. Left Ventricular Diastolic Function during Positive End-expiratory Pressure: Impact of Right Ventricular Ischemia and Ventricular Interaction. American Journal Of Respiratory And Critical Care Medicine 1992, 145: 515-521. PMID: 1546829, DOI: 10.1164/ajrccm/145.3.515.Peer-Reviewed Original ResearchConceptsPositive end-expiratory pressureLeft ventricular end-diastolic pressure-volume relationEnd-expiratory pressureRCA occlusionEnd-diastolic volumeEnd-systolic volumeCardiac outputEjection fractionRight ventricularAddition of PEEPRight coronary artery occlusionEnd-diastolic pressure-volume relationRight ventricular ischemiaVentricular diastolic functionVentricular ejection fractionCoronary artery occlusionArtery occlusionAtrial pressureDiastolic functionPressure-volume relationVentricular ischemiaAnesthetized dogsVentricular interactionLV volumesRVEDV