2000
PET quantification of 5-HT2A receptors in the human brain: a constant infusion paradigm with [18F]altanserin.
van Dyck CH, Tan PZ, Baldwin RM, Amici LA, Garg PK, Ng CK, Soufer R, Charney DS, Innis RB. PET quantification of 5-HT2A receptors in the human brain: a constant infusion paradigm with [18F]altanserin. Journal Of Nuclear Medicine 2000, 41: 234-41. PMID: 10688105.Peer-Reviewed Original ResearchConceptsConstant infusion paradigmInfusion paradigmFrontal cortexAnterior cingulateVenous blood samplingPathophysiology of schizophreniaLipophilic radiometabolitesIntravenous administrationInfusion periodHealthy volunteersPET acquisitionReceptor densityBlood samplingTime-activity curvesConstant infusionLinear regression analysisH onwardMetabolite concentrationsBrain activityRegression analysisCingulateCortexHuman brainReceptorsPET quantification
1999
Quantitation of benzodiazepine receptor binding with PET [11C]iomazenil and SPECT [123I]iomazenil: preliminary results of a direct comparison in healthy human subjects
Bremner J, Baldwin R, Horti A, Staib L, Ng C, Tan P, Zea-Ponce Y, Zoghbi S, Seibyl J, Soufer R, Charney D, Innis R. Quantitation of benzodiazepine receptor binding with PET [11C]iomazenil and SPECT [123I]iomazenil: preliminary results of a direct comparison in healthy human subjects. Psychiatry Research 1999, 91: 79-91. PMID: 10515463, DOI: 10.1016/s0925-4927(99)00015-3.Peer-Reviewed Original ResearchConceptsPositron emission tomographyBenzodiazepine receptorsArterial blood samplesBenzodiazepine receptor bindingHealthy human subjectsHuman subjectsNeuroreceptor bindingSingle photon emissionSingle bolusOccipital cortexBlood samplesTemporal cortexEmission tomographyBrain compartmentsDynamic positron emission tomographyReceptor bindingSPECTSame human subjectsPhoton emissionCortexHuman brainRadioligandPreliminary findingsBrainReceptors