2024
Incidence of Concurrent Cerebral Desaturation and Electroencephalographic Burst Suppression in Cardiac Surgery Patients.
Ramachandran R, Behera A, Hussain Z, Peck J, Ananthakrishanan A, Mathur P, Banner-Goodspeed V, Muehlschlegel J, Pittet J, Bardia A, Schonberger R, Marcantonio E, Kveraga K, Subramaniam B. Incidence of Concurrent Cerebral Desaturation and Electroencephalographic Burst Suppression in Cardiac Surgery Patients. Anesthesia & Analgesia 2024 PMID: 39446661, DOI: 10.1213/ane.0000000000007209.Peer-Reviewed Original ResearchCerebral desaturationAortic cross-clampingCardiac surgeryPost-CPBBurst suppressionCross-clampingRemoval of aortic cross-clampCerebral oximetryAssociated with postoperative deliriumPhase of cardiac surgeryCardiac surgery patientsElectroencephalographic burst suppressionConfidence intervalsIntraoperative burst suppressionPostoperative cognitive functionPre-CPBPrecardiopulmonary bypassSurgery patientsEntire surgeryEEG monitoringPostoperative deliriumTargeted interventionsOdds ratioSurgerySurgical phaseOpioid Dose Variation in Cardiac Surgery: A Multicenter Study of Practice.
Fisher C, Janda A, Zhao X, Deng Y, Bardia A, Yanez N, Burns M, Aziz M, Treggiari M, Mathis M, Lin H, Schonberger R. Opioid Dose Variation in Cardiac Surgery: A Multicenter Study of Practice. Anesthesia & Analgesia 2024 PMID: 39167548, DOI: 10.1213/ane.0000000000007128.Peer-Reviewed Original ResearchCardiac surgeryOpioid doseDose variationIntraoperative opioid administrationIntraoperative opioid doseHigh-dose opioidsAdult cardiac surgerySurgical differencesOpioid-freeOpioid administrationOpioid useMultimodal analgesiaAnalgesic techniquesCardiopulmonary bypassMulticenter studyFentanyl equivalentsSufentanil infusionSurgical patientsOpioidSurgeryAnesthetic techniqueCardiac casesAttending anesthesiologistPatientsDose
2023
Patient-, Clinician-, and Institution-level Variation in Inotrope Use for Cardiac Surgery: A Multicenter Observational Analysis
Mathis M, Janda A, Kheterpal S, Schonberger R, Pagani F, Engoren M, Mentz G, Shook D, Muehlschlegel J, Cassidy R, Clark D, Colquhoun D, Freundlich R, Jewell E. Patient-, Clinician-, and Institution-level Variation in Inotrope Use for Cardiac Surgery: A Multicenter Observational Analysis. Anesthesiology 2023, 139: 122-141. PMID: 37094103, PMCID: PMC10524016, DOI: 10.1097/aln.0000000000004593.Peer-Reviewed Original ResearchConceptsInotrope useCardiac surgeryHome medicationsAdjusted median odds ratioPulmonary circulation disordersAdult cardiac surgeryMechanical circulatory supportMedian odds ratioMedical school affiliationHome inotropesInotrope infusionInotrope therapyInotropic therapyCardiopulmonary bypassHeart failureMulticenter cohortPrimary outcomeCirculatory supportBlack raceCirculation disordersOdds ratioCommunity hospitalObservational studySame patientPatientsAssociation of adherence to individual components of Society of Thoracic Surgeons cardiac surgery antibiotic guidelines and postoperative infections
Bardia A, Michel G, Farela A, Fisher C, Mori M, Huttler J, Lang A, Geirsson A, Schonberger R. Association of adherence to individual components of Society of Thoracic Surgeons cardiac surgery antibiotic guidelines and postoperative infections. Journal Of Thoracic And Cardiovascular Surgery 2023, 167: 2170-2176.e5. PMID: 37075942, PMCID: PMC10579454, DOI: 10.1016/j.jtcvs.2023.03.031.Peer-Reviewed Original ResearchWeight-adjusted dosingPostoperative infectionAntibiotic guidelinesIncidence of nonadherenceCoronary artery bypassTertiary care hospitalAssociation of adherenceCohort of patientsRetrospective observational studyPost-operative infectionIntraoperative redosingValvular surgeryAntibiotic timingArtery bypassCoronary revascularizationPostoperative complicationsPostoperative sepsisAdult patientsFirst doseAntibiotic choiceCardiac surgeryCardiopulmonary bypassCare hospitalDose adjustmentPrimary outcome
2022
Efficacy and Safety of Sugammadex to Shorten Time-to-Extubation Following Cardiac Surgery: A Single-Center Randomized Placebo-Controlled Trial
Bardia A, Treggiari M, Dai F, Johnson C, Singh M, Kunze K, Tickoo M, Tantawy H, Giersson A, Darr U, Schonberger R. Efficacy and Safety of Sugammadex to Shorten Time-to-Extubation Following Cardiac Surgery: A Single-Center Randomized Placebo-Controlled Trial. Critical Care Explorations 2022, 4: e0821. PMID: 36601562, PMCID: PMC9788969, DOI: 10.1097/cce.0000000000000821.Peer-Reviewed Original ResearchAortic valve replacementCardiac surgeryNeuromuscular blockadeCombined Aortic Valve ReplacementElective aortic valve replacementEfficacy of sugammadexStudy drug administrationCoronary artery bypassPlacebo-controlled trialPrimary study endpointResidual neuromuscular blockadeUse of sugammadexArtery bypassPlacebo groupSugammadex groupBaseline characteristicsValve replacementAnesthetic medicationsStudy endpointMechanical ventilationModifiable factorsCardiothoracic ICUICU settingNMB reversalPatients
2019
Preoperative chlorhexidine mouthwash to reduce pneumonia after cardiac surgery: A systematic review and meta-analysis
Bardia A, Blitz D, Dai F, Hersey D, Jinadasa S, Tickoo M, Schonberger RB. Preoperative chlorhexidine mouthwash to reduce pneumonia after cardiac surgery: A systematic review and meta-analysis. Journal Of Thoracic And Cardiovascular Surgery 2019, 158: 1094-1100. PMID: 30826096, DOI: 10.1016/j.jtcvs.2019.01.014.Peer-Reviewed Original ResearchConceptsPreoperative chlorhexidine mouthwashChlorhexidine gluconate mouthwashPostoperative pneumoniaCardiac surgeryChlorhexidine mouthwashHealth care burdenQuality of evidenceComprehensive systematic searchRandom-effects modelPreoperative chlorhexidineRecommendations AssessmentCommon complicationPrimary outcomePreoperative protocolPatient morbidityRisk ratioPatient outcomesCare burdenReduced riskIndependent reviewersCumulative IndexPneumoniaNLM PubMedChlorhexidine gluconatePatients
2013
Elimination of Gaseous Microemboli From Cardiopulmonary Bypass Using Hypobaric Oxygenation
Gipson KE, Rosinski DJ, Schonberger RB, Kubera C, Mathew ES, Nichols F, Dyckman W, Courtin F, Sherburne B, Bordey AF, Gross JB. Elimination of Gaseous Microemboli From Cardiopulmonary Bypass Using Hypobaric Oxygenation. The Annals Of Thoracic Surgery 2013, 97: 879-886. PMID: 24206970, PMCID: PMC4294693, DOI: 10.1016/j.athoracsur.2013.08.074.Peer-Reviewed Original ResearchConceptsCardiopulmonary bypassSweep gasGaseous microemboliEnd-organ damageApparent adverse eventsEnd-organ tissuesDose-dependent reductionCurrent practice standardsVariety of patientsMicrovascular injuryGas pressureMicroporous membrane oxygenatorAdverse eventsCardiac surgeryCPB circuitAir embolismExtracorporeal circulationArterial circulationArterial bloodEnd organsGME volumeArterial filterProgressive reabsorptionAortic cannulaDissolved gasesNew Utility for an Old Tool
Odonkor CA, Schonberger RB, Dai F, Shelley KH, Silverman DG, Barash PG. New Utility for an Old Tool. American Journal Of Physical Medicine & Rehabilitation 2013, 92: 849-863. PMID: 24051992, PMCID: PMC3850792, DOI: 10.1097/phm.0b013e3182a51ac5.Peer-Reviewed Original ResearchConceptsElective ambulatory surgeryUnplanned admissionsAmbulatory surgeryGait speedOdds ratioPrimary outcomeDischarge readinessProspective observational cohort studyMultivariable logistic regression modelSeparate multivariable logistic regression modelsEarly home dischargeHome discharge timePreoperative gait speedObservational cohort studyTotal anesthesia timeAdjusted odds ratioGait speed testingLogistic regression modelsCohort studyHome dischargeCardiac surgeryAnesthesia timeHeart rateSurgeryAdmission