1998
Vaccination against Lyme Disease with Recombinant Borrelia burgdorferi Outer-Surface Lipoprotein A with Adjuvant
Steere A, Sikand V, Meurice F, Parenti D, Fikrig E, Schoen R, Nowakowski J, Schmid C, Laukamp S, Buscarino C, Krause D. Vaccination against Lyme Disease with Recombinant Borrelia burgdorferi Outer-Surface Lipoprotein A with Adjuvant. New England Journal Of Medicine 1998, 339: 209-215. PMID: 9673298, DOI: 10.1056/nejm199807233390401.Peer-Reviewed Original ResearchConceptsLyme diseaseSerologic testingVaccine efficacyAsymptomatic infectionLipoprotein AInjections of vaccineOuter surface lipoprotein AB. burgdorferi infectionFirst yearPlacebo recipientsPlacebo groupVaccine groupVaccine recipientsStudy entryRandomized trialsSystemic reactionsThird injectionBurgdorferi infectionEffective vaccineSkin lesionsReaction testingVaccineDefinite casesDiseaseInfection
1994
IDENTIFICATION OF LYME DISEASE
Schoen R. IDENTIFICATION OF LYME DISEASE. Rheumatic Disease Clinics Of North America 1994, 20: 361-369. PMID: 8016416, DOI: 10.1016/s0889-857x(21)00053-3.Peer-Reviewed Original ResearchConceptsLate Lyme diseaseLyme diseaseSerologic testingMinority of patientsEarly Lyme diseaseChronic meningitisMost patientsRheumatic diseasesEarly diseaseChronic fatigueSuccessful treatmentDisease manifestationsHigh indexDiseasePatientsB. burgdorferiMost individualsAntibioticsTreatmentIndividualsOligoarthritisMeningitisRashSeroreactivityClinicians