2023
Can multisite clinical trial results change clinical practice? Use of long-acting injectable risperidone nationally in the Veterans Health Administration
Rosenheck R, Anand S, Kurtz S, Hau C, Smedberg D, Pontzer J, Ferguson R, Davis C. Can multisite clinical trial results change clinical practice? Use of long-acting injectable risperidone nationally in the Veterans Health Administration. Trials 2023, 24: 85. PMID: 36747254, PMCID: PMC9900548, DOI: 10.1186/s13063-023-07094-6.Peer-Reviewed Original ResearchMeSH KeywordsAntipsychotic AgentsDelayed-Action PreparationsHumansInjectionsPaliperidone PalmitateRisperidoneVeterans HealthConceptsSecond-generation antipsychoticsLAI risperidoneClinical practiceLAI second-generation antipsychoticsInjectable second-generation antipsychoticsPractical clinical trialsVeterans Health AdministrationClinical trial resultsStudy publicationDiagnosis of schizophreniaNational administrative dataLongitudinal observational analysisLAI paliperidoneOral antipsychoticsReal-world practiceInjectable risperidoneTrial findingsClinical trialsLAI treatmentRisperidoneSchizoaffective disorderHealth AdministrationCooperative StudyAntipsychoticsDrug expendituresImpact of multi-site clinical trial results on clinical practice: Use of risperidone to treat PTSD nationally in the veterans health administration
Rosenheck R, Kurtz S, Anand S, Hau C, Smedberg D, Sicilia R, Pontzer J, Ferguson R. Impact of multi-site clinical trial results on clinical practice: Use of risperidone to treat PTSD nationally in the veterans health administration. Psychiatry Research 2023, 321: 115071. PMID: 36720177, DOI: 10.1016/j.psychres.2023.115071.Peer-Reviewed Original ResearchMeSH KeywordsAntipsychotic AgentsHumansRisperidoneStress Disorders, Post-TraumaticUnited StatesUnited States Department of Veterans AffairsVeteransVeterans HealthConceptsClinical practiceNational VHA administrative dataOral second-generation antipsychoticsUse of risperidoneVHA administrative dataSecond-generation antipsychoticsMulti-site clinical trialVeterans Health AdministrationClinical trialsEffectiveness trialHealth AdministrationRisperidoneCooperative StudyYear of publicationAdministrative dataPTSDTrialsYearsAntipsychoticsStudy resultsAdministrationGender differences in outcomes of early intervention services for first episode psychosis
Hong S, Bennett D, Rosenheck R. Gender differences in outcomes of early intervention services for first episode psychosis. Early Intervention In Psychiatry 2023, 17: 715-723. PMID: 36623822, PMCID: PMC10329725, DOI: 10.1111/eip.13367.Peer-Reviewed Original ResearchMeSH KeywordsAntipsychotic AgentsFemaleHumansMalePsychotic DisordersQuality of LifeSchizophreniaSex FactorsConceptsFirst-episode psychosisEarly intervention servicesClinical trialsEpisode psychosisInitial Schizophrenia Episode-Early Treatment Program (RAISE-ETP) studyEarly interventionIntervention servicesRandomized clinical trialsComorbid substance useUS clinical trialsSignificant gender differencesNegative Syndrome ScaleBaseline gender differencesGender differencesSchizophrenia spectrum disordersAntipsychotic exposureUsual careBaseline characteristicsMood symptomsDepression subscalePsychotic disordersMasked evaluatorsSchizoaffective disorderSyndrome ScaleSecondary analysis
2013
Second generation antipsychotics: evolution of scientific knowledge or uncovering fraud
Rosenheck R. Second generation antipsychotics: evolution of scientific knowledge or uncovering fraud. Epidemiology And Psychiatric Sciences 2013, 22: 235-237. PMID: 23388147, PMCID: PMC8367331, DOI: 10.1017/s2045796012000662.Peer-Reviewed Original Research
2009
Developing A Policy For Second-Generation Antipsychotic Drugs
Rosenheck RA, Sernyak MJ. Developing A Policy For Second-Generation Antipsychotic Drugs. Health Affairs 2009, 28: w782-w793. PMID: 19622538, DOI: 10.1377/hlthaff.28.5.w782.Peer-Reviewed Original ResearchMeSH KeywordsAntipsychotic AgentsComparative Effectiveness ResearchCost-Benefit AnalysisDrug CostsHealth PolicyHumansSchizophreniaUnited StatesConceptsSecond-generation antipsychoticsAntipsychotic drugsRisk/benefit profileSecond-generation antipsychotic drugsMetabolic side effectsTreatment of schizophreniaAdverse eventsBenefit profileLower riskOld drugsSide effectsPrior authorizationDrugsCheaper drugsGeneric drugsEducational preparationWidespread implementationGood acceptanceSuch proceduresAntipsychoticsPatientsTherapySchizophrenia
2007
Cost-Benefit Analysis of Second-Generation Antipsychotics and Placebo in a Randomized Trial of the Treatment of Psychosis and Aggression in Alzheimer Disease
Rosenheck RA, Leslie DL, Sindelar JL, Miller EA, Tariot PN, Dagerman KS, Davis SM, Lebowitz BD, Rabins P, Hsiao JK, Lieberman JA, Schneider LS. Cost-Benefit Analysis of Second-Generation Antipsychotics and Placebo in a Randomized Trial of the Treatment of Psychosis and Aggression in Alzheimer Disease. JAMA Psychiatry 2007, 64: 1259-1268. PMID: 17984395, DOI: 10.1001/archpsyc.64.11.1259.Peer-Reviewed Original ResearchConceptsCost-benefit analysisSecond-generation antipsychoticsGreatest net health benefitNet benefit analysisNet health benefitWholesale priceHealth Utilities Index Mark 3Economic perspectiveAlzheimer's diseaseBenefit approachHealth care costsTotal health costsHealth costsQALYsCare costsMeasures of effectivenessPlacebo-controlled trialLower health care costsHealth service useTotal health careMeasures of functionCostTreatment of psychosisQuality of lifeSensitivity analysisEvaluating the cost-effectiveness of reduced tardive dyskinesia with second-generation antipsychotics
Rosenheck R. Evaluating the cost-effectiveness of reduced tardive dyskinesia with second-generation antipsychotics. The British Journal Of Psychiatry 2007, 191: 238-245. PMID: 17766765, DOI: 10.1192/bjp.bp.106.035063.Peer-Reviewed Original ResearchDr. Rosenheck and Colleagues Reply
ROSENHECK R, STROUP T, SWARTZ M, McEVOY J, DAVIS S, KEEFE R, HSIAO J, LIEBERMAN J. Dr. Rosenheck and Colleagues Reply. American Journal Of Psychiatry 2007, 164: 678-680. PMID: 17403984, DOI: 10.1176/ajp.2007.164.4.678a.Peer-Reviewed Original ResearchPractical applications of recent antipsychotic effectiveness data.
Lieberman J, Harvey P, Newcomer J, Rosenheck R. Practical applications of recent antipsychotic effectiveness data. The Journal Of Clinical Psychiatry 2007, 68: 151-62. PMID: 17284143, DOI: 10.4088/jcp.v68n0120.Peer-Reviewed Original Research
2006
Cost-Effectiveness of Second-Generation Antipsychotics and Perphenazine in a Randomized Trial of Treatment for Chronic Schizophrenia
Rosenheck RA, Leslie DL, Sindelar J, Miller EA, Lin H, Stroup TS, McEvoy J, Davis SM, Keefe RS, Swartz M, Perkins DO, Hsiao JK, Lieberman J. Cost-Effectiveness of Second-Generation Antipsychotics and Perphenazine in a Randomized Trial of Treatment for Chronic Schizophrenia. American Journal Of Psychiatry 2006, 163: 2080-2089. PMID: 17151158, DOI: 10.1176/ajp.2006.163.12.2080.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAntipsychotic AgentsChronic DiseaseCost-Benefit AnalysisDrug CostsFollow-Up StudiesHealth Care CostsHumansLongitudinal StudiesMiddle AgedPatient DropoutsPerphenazinePsychiatric Status Rating ScalesQuality-Adjusted Life YearsResearch DesignSchizophreniaSchizophrenic PsychologyTreatment Outcome
2001
Neuroleptic Use in the Treatment of Post-Traumatic Stress Disorder
Sernyak M, Kosten T, Fontana A, Rosenheck R. Neuroleptic Use in the Treatment of Post-Traumatic Stress Disorder. Psychiatric Quarterly 2001, 72: 197-213. PMID: 11467155, DOI: 10.1023/a:1010318414199.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntipsychotic AgentsCombat DisordersHumansMaleMiddle AgedPersonality InventoryRetrospective StudiesTreatment OutcomeVeteransConceptsPost-traumatic stress disorderTreatment of PTSDNeuroleptic useOutcome studiesStress disorderSevere post-traumatic stress disorderLarge outcome studiesUse of neurolepticsNeuroleptic-treated patientsObservational outcome studyCombat-related post-traumatic stress disorderIll patientsMedication historyClinical variablesNeuroleptic prescriptionSocio-demographic characteristicsTreatment characteristicsBaseline differencesNeurolepticsPatientsSecondary analysisPTSD symptomsCombat exposureTreatmentOutpatientsUse of Pharmacy Data to Assess Quality of Pharmacotherapy for Schizophrenia in a National Health Care System
Leslie D, Rosenheck R. Use of Pharmacy Data to Assess Quality of Pharmacotherapy for Schizophrenia in a National Health Care System. Medical Care 2001, 39: 923-933. PMID: 11502950, DOI: 10.1097/00005650-200109000-00003.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAdultAntipsychotic AgentsComorbidityDelivery of Health Care, IntegratedDiagnosis, Dual (Psychiatry)FemaleGuideline AdherenceHumansMaleMental Health ServicesMiddle AgedNational Health ProgramsOutcome and Process Assessment, Health CarePatient CompliancePolypharmacyPractice Guidelines as TopicSchizophreniaUnited StatesUnited States Department of Veterans AffairsConceptsPatient Outcomes Research TeamLarger mental health systemMultiple antipsychotic medicationsAntipsychotic medicationPORT recommendationsSchizophrenia Patient Outcomes Research TeamVeterans AffairsHealth systemTotal weekly doseTreatment of schizophreniaPrescription drug recordsMental health systemHealth care systemGeneralized estimation equationsMultiple antipsychoticsNational Health SystemOlder patientsWeekly doseNational health care systemPharmacy dataComorbid depressionTreatment recommendationsDrug recordsMedicationsPatientsNational Institute of Mental Health Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE): Alzheimer Disease Trial Methodology
Schneider L, Tariot P, Lyketsos C, Dagerman K, Davis K, Davis S, Hsiao J, Jeste D, Katz I, Olin J, Pollock B, Rabins P, Rosenheck R, Small G, Lebowitz B, Lieberman J. National Institute of Mental Health Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE): Alzheimer Disease Trial Methodology. American Journal Of Geriatric Psychiatry 2001, 9: 346-360. PMID: 11739062, DOI: 10.1097/00019442-200111000-00004.Peer-Reviewed Original ResearchThe Effect of Institutional Fiscal Stress on the Use of Atypical Antipsychotic Medications in the Treatment of Schizophrenia
LESLIE D, ROSENHECK R. The Effect of Institutional Fiscal Stress on the Use of Atypical Antipsychotic Medications in the Treatment of Schizophrenia. The Journal Of Nervous And Mental Disease 2001, 189: 377-383. PMID: 11434638, DOI: 10.1097/00005053-200106000-00005.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseAntipsychotic AgentsBenzodiazepinesBudgetsClozapineComorbidityDepressive DisorderDrug CostsFemaleHealth Care CostsHealth FacilitiesHumansMaleMiddle AgedOlanzapinePirenzepinePractice Patterns, Physicians'Regression AnalysisRisperidoneSchizophreniaTreatment OutcomeUnited StatesUnited States Department of Veterans AffairsConceptsAtypical antipsychotic medicationsTreatment of schizophreniaAtypical antipsychoticsAntipsychotic medicationExpensive atypical antipsychotic medicationsVeterans AffairsPrescription drug recordsGeneralized estimation equationsDrug recordsPatientsReduced likelihoodAntipsychoticsMedicationsFacility characteristicsSchizophreniaAtypicalsFinal sampleTreatmentOlanzapineRisperidone
1999
Interrater Reliability Levels of Multiple Clinical Examiners in the Evaluation of a Schizophrenic Patient: Quality of Life, Level of Functioning, and Neuropsychological Symptomatology
Cicchetti D, Rosenheck R, Showalter D, Charney D, Cramer J. Interrater Reliability Levels of Multiple Clinical Examiners in the Evaluation of a Schizophrenic Patient: Quality of Life, Level of Functioning, and Neuropsychological Symptomatology. The Clinical Neuropsychologist 1999, 13: 157-170. PMID: 10949157, DOI: 10.1076/clin.13.2.157.1965.Peer-Reviewed Original ResearchClozapine and Suicide
Sernyak M, Hoff R, Rosenheck R. Clozapine and Suicide. Psychiatric Services 1999, 50: 116-116. PMID: 9890596, DOI: 10.1176/ps.50.1.116.Peer-Reviewed Original Research
1998
Predictors of differential response to clozapine and haloperidol
Rosenheck R, Lawson W, Crayton J, Cramer J, Xu W, Thomas J, Stolar M, Charney D, Schizophrenia F. Predictors of differential response to clozapine and haloperidol. Biological Psychiatry 1998, 44: 475-482. PMID: 9777179, DOI: 10.1016/s0006-3223(98)00117-6.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAntipsychotic AgentsClozapineDouble-Blind MethodDrug ResistanceFemaleHaloperidolHumansMalePsychiatric Status Rating ScalesQuality of LifeRacial GroupsSchizophreniaSchizophrenic PsychologySocial SupportTreatment OutcomeUnited StatesUnited States Department of Veterans AffairsConceptsQuality of lifeThree-month outcomeOnset of schizophreniaSeverity of symptomsGreater symptom reductionGreater improvementRefractory patientsRefractory schizophreniaClozapine treatmentHospital daysClinical predictorsExtrapyramidal symptomsHospitalized patientsClinical trialsBaseline predictorsSample patientsSide effectsSymptom reductionClozapinePatientsSymptomsHigher symptomsHigh levelsHaloperidolMultiple regression analysisCompliance With Medication Regimens for Mental and Physical Disorders
Cramer J, Rosenheck R. Compliance With Medication Regimens for Mental and Physical Disorders. Psychiatric Services 1998, 49: 196-201. PMID: 9575004, DOI: 10.1176/ps.49.2.196.Peer-Reviewed Original ResearchMeSH KeywordsAntidepressive AgentsAntipsychotic AgentsDrug MonitoringHealth StatusHumansMental DisordersPatient ComplianceTime FactorsConceptsMedication complianceCompliance rateMicroelectronic monitoringMedication regimensPhysical disordersPsychiatric treatmentMedication compliance ratesDiscontinuation of medicationMean compliance rateAntidepressant medicationPill countAntipsychotic medicationNonpsychiatric disordersPatient compliancePsychiatric disordersPatientsPsychiatric patientsClinician judgmentMedicationsDisordersRegimensLower ratesTreatmentReportPercent
1997
A Comparison of Clozapine and Haloperidol in Hospitalized Patients with Refractory Schizophrenia
Rosenheck R, Cramer J, Xu W, Thomas J, Henderson W, Frisman L, Fye C, Charney D. A Comparison of Clozapine and Haloperidol in Hospitalized Patients with Refractory Schizophrenia. New England Journal Of Medicine 1997, 337: 809-815. PMID: 9295240, DOI: 10.1056/nejm199709183371202.Peer-Reviewed Original ResearchConceptsClozapine groupExtrapyramidal side effectsHaloperidol groupRefractory schizophreniaSide effectsAntipsychotic drugsDouble-blind comparative studyVeterans Affairs Medical CenterMore outpatient servicesNegative Syndrome ScaleComparison of clozapineLower symptom levelsSimilar overall costsHospitalized patientsTreat analysisTardive dyskinesiaPsychiatric reasonsLower incidenceMedical CenterOutpatient servicesHospital usePatientsSyndrome ScaleClozapineHaloperidol