Can multisite clinical trial results change clinical practice? Use of long-acting injectable risperidone nationally in the Veterans Health Administration
Rosenheck R, Anand S, Kurtz S, Hau C, Smedberg D, Pontzer J, Ferguson R, Davis C. Can multisite clinical trial results change clinical practice? Use of long-acting injectable risperidone nationally in the Veterans Health Administration. Trials 2023, 24: 85. PMID: 36747254, PMCID: PMC9900548, DOI: 10.1186/s13063-023-07094-6.Peer-Reviewed Original ResearchConceptsSecond-generation antipsychoticsLAI risperidoneClinical practiceLAI second-generation antipsychoticsInjectable second-generation antipsychoticsPractical clinical trialsVeterans Health AdministrationClinical trial resultsStudy publicationDiagnosis of schizophreniaNational administrative dataLongitudinal observational analysisLAI paliperidoneOral antipsychoticsReal-world practiceInjectable risperidoneTrial findingsClinical trialsLAI treatmentRisperidoneSchizoaffective disorderHealth AdministrationCooperative StudyAntipsychoticsDrug expendituresGender differences in outcomes of early intervention services for first episode psychosis
Hong S, Bennett D, Rosenheck R. Gender differences in outcomes of early intervention services for first episode psychosis. Early Intervention In Psychiatry 2023, 17: 715-723. PMID: 36623822, PMCID: PMC10329725, DOI: 10.1111/eip.13367.Peer-Reviewed Original ResearchConceptsFirst-episode psychosisEarly intervention servicesClinical trialsEpisode psychosisInitial Schizophrenia Episode-Early Treatment Program (RAISE-ETP) studyEarly interventionIntervention servicesRandomized clinical trialsComorbid substance useUS clinical trialsSignificant gender differencesNegative Syndrome ScaleBaseline gender differencesGender differencesSchizophrenia spectrum disordersAntipsychotic exposureUsual careBaseline characteristicsMood symptomsDepression subscalePsychotic disordersMasked evaluatorsSchizoaffective disorderSyndrome ScaleSecondary analysis