2018
Co-occurring Substance and Mental Health Disorders
Jorandby-Quinones L, Edens E, Rosenheck R. Co-occurring Substance and Mental Health Disorders. 2018, 307-333. DOI: 10.1007/978-1-4939-7438-2_20.ChaptersDual diagnosisMental health care deliveryHigh treatment burdenMore medical conditionsMental health care systemMental health disordersSubstance use disordersCo-occurring substanceEvolution of treatmentHealthcare delivery approachHealth care deliveryHealth care systemTreatment burdenMedical conditionsUse disordersHealth disordersMedical carePatientsCare deliveryPsychosocial conditionsIndividual diseasesCare systemDiagnosisTreatmentDisease
2013
National psychotropic prescription dispensation among dually diagnosed patients
Marienfeld C, Rosenheck R. National psychotropic prescription dispensation among dually diagnosed patients. Advances In Dual Diagnosis 2013, 6: 34-44. DOI: 10.1108/17570971311309015.Peer-Reviewed Original ResearchAnalysis of covarianceNational Veterans Health AdministrationOutpatient mental health visitsMental health service useMental health visitsHealth service useVeterans Health AdministrationSevere mental illnessDrug-drug interactionsSchizophrenia spectrum disordersPrescription dispensationMedication classesClinic visitsClinical confoundersPharmacy recordsHealth visitsPsychotropic prescriptionsMood stabilizersPsychotropic medicationsMore prescriptionsHigh riskPatientsService useHealth AdministrationBipolar disorder
2012
Cigarette smoking, psychopathology and cognitive function in first-episode drug-naive patients with schizophrenia: a case-control study
Zhang X, Chen D, Xiu M, Haile C, He S, Luo X, Zuo L, Rosenheck R, Kosten T, Kosten T. Cigarette smoking, psychopathology and cognitive function in first-episode drug-naive patients with schizophrenia: a case-control study. Psychological Medicine 2012, 43: 1651-1660. PMID: 23149169, DOI: 10.1017/s0033291712002590.Peer-Reviewed Original ResearchConceptsDrug-naive patientsFES patientsGeneral populationCognitive functionChronic schizophreniaHealthy controlsSmoking ratesFirst-episode drug-naive patientsFirst-episode schizophrenia patientsQuantity of smokingPositive symptom subscale scoresCase-control studyHigh smoking ratesSymptom subscale scoresCase-control designNegative Symptom ScaleTotal PANSSCigarette smokingFirst episodeNicotine dependenceFagerström TestPatientsPsychotic disordersSmokingSymptom Scale
2010
Does Switching to a New Antipsychotic Improve Outcomes? Data from the CATIE Trial
Rosenheck R, Davis S, Covell N, Essock S, Swart M, Stroup S, McEvoy J, Lieberman J. Does Switching to a New Antipsychotic Improve Outcomes? Data from the CATIE Trial. FOCUS The Journal Of Lifelong Learning In Psychiatry 2010, 8: 561-569. DOI: 10.1176/foc.8.4.foc561.Peer-Reviewed Original ResearchGreater weight gainNew medicationsOutcome measuresWeight gainNeurological side effectsAdditional outcome measuresPotential confounding factorsQuality of lifeStudy drugPrevious medicationCATIE trialMultivariate adjustmentImprove OutcomesMedicationsSide effectsOlanzapinePatientsConfounding factorsDrugsHealth costsOutcomesSignificant differencesRisperidoneCATIEMixed models
2009
Developing A Policy For Second-Generation Antipsychotic Drugs
Rosenheck RA, Sernyak MJ. Developing A Policy For Second-Generation Antipsychotic Drugs. Health Affairs 2009, 28: w782-w793. PMID: 19622538, DOI: 10.1377/hlthaff.28.5.w782.Peer-Reviewed Original ResearchConceptsSecond-generation antipsychoticsAntipsychotic drugsRisk/benefit profileSecond-generation antipsychotic drugsMetabolic side effectsTreatment of schizophreniaAdverse eventsBenefit profileLower riskOld drugsSide effectsPrior authorizationDrugsCheaper drugsGeneric drugsEducational preparationWidespread implementationGood acceptanceSuch proceduresAntipsychoticsPatientsTherapySchizophrenia
2006
Effectiveness of Olanzapine, Quetiapine, Risperidone, and Ziprasidone in Patients With Chronic Schizophrenia Following Discontinuation of a Previous Atypical Antipsychotic
Stroup T, Lieberman J, McEvoy J, Swartz M, Davis S, Rosenheck R, Perkins D, Keefe R, Davis C, Severe J, Hsiao J. Effectiveness of Olanzapine, Quetiapine, Risperidone, and Ziprasidone in Patients With Chronic Schizophrenia Following Discontinuation of a Previous Atypical Antipsychotic. FOCUS The Journal Of Lifelong Learning In Psychiatry 2006, 4: 539-552. DOI: 10.1176/foc.4.4.539.Peer-Reviewed Original ResearchAtypical antipsychoticsChronic schizophreniaDouble-blind treatmentDouble-blind studyGroup of patientsDifferent atypical antipsychoticsEffectiveness of olanzapineTreatment of schizophreniaClinical Antipsychotic TrialsTreatment discontinuationPrevious antipsychoticDifferent antipsychoticsAntipsychotic TrialsAntipsychoticsQuetiapineDiscontinuationPatientsOlanzapineRisperidoneZiprasidonePrevious treatmentSchizophreniaTreatmentSignificant differencesPrimary aim
2003
IMPACT OF PUBLIC SUPPORT PAYMENTS, INTENSIVE PSYCHIATRIC COMMUNITY CARE, AND PROGRAM FIDELITY ON EMPLOYMENT OUTCOMES FOR PEOPLE WITH SEVERE MENTAL ILLNESS
RESNICK S, NEALE M, ROSENHECK R. IMPACT OF PUBLIC SUPPORT PAYMENTS, INTENSIVE PSYCHIATRIC COMMUNITY CARE, AND PROGRAM FIDELITY ON EMPLOYMENT OUTCOMES FOR PEOPLE WITH SEVERE MENTAL ILLNESS. The Journal Of Nervous And Mental Disease 2003, 191: 139. DOI: 10.1097/00005053-200303000-00001.Peer-Reviewed Original ResearchIntensive psychiatric community careSevere mental illnessPublic support paymentsMental illnessPsychiatric community careStudy entryControl subjectsClinical trialsCommunity careMultivariate analysisLower likelihoodIllnessProgram fidelityCareOutcomesSignificant interactionEmployment outcomesParticipantsPatientsFidelity of implementationYearsPsychiatricTrials
2001
Naltrexone in the Treatment of Alcohol Dependence
Krystal J, Cramer J, Krol W, Kirk G, Rosenheck R. Naltrexone in the Treatment of Alcohol Dependence. New England Journal Of Medicine 2001, 345: 1734-1739. PMID: 11742047, DOI: 10.1056/nejmoa011127.Peer-Reviewed Original ResearchConceptsMonths of placeboSevere alcohol dependenceAlcohol dependencePlacebo-controlled evaluationUse of naltrexoneOpiate receptor antagonistTreatment of menSignificant differencesPercentage of daysStudy medicationNaltrexone groupPlacebo groupNumber of drinksAlcoholics Anonymous meetingsPsychosocial treatmentsNaltrexoneDrug AdministrationPatientsMonthsIndividual counselingNumber of daysPlaceboTreatmentWeeksDaysUsing a computerized patient database to evaluate guideline adherence and measure patterns of care for major depression
Rosenheck R, Chen R. Using a computerized patient database to evaluate guideline adherence and measure patterns of care for major depression. The Journal Of Behavioral Health Services & Research 2001, 28: 466-474. PMID: 11732248, DOI: 10.1007/bf02287776.Peer-Reviewed Original ResearchConceptsPatterns of careMajor depressionGuideline adherenceGuideline recommendationsOutpatient mental health appointmentsVeterans Affairs Medical CenterComputerized database analysisMental health appointmentsMonths of dischargeComputerized patient databaseNumber of followTranslation of recommendationsHealth care policyAntidepressant therapyHealth appointmentsMedical CenterAlcohol abuseDual diagnosisTreatment interventionsPatient databaseComputerized databasePatientsConcurrent alcoholismDatabase analysisDepressionImpact of Clozapine Prescription on Inpatient Resource Utilization
SERNYAK M, ROSENHECK R, DESAI R, STOLAR M, RIPPER G. Impact of Clozapine Prescription on Inpatient Resource Utilization. The Journal Of Nervous And Mental Disease 2001, 189: 766-773. PMID: 11758660, DOI: 10.1097/00005053-200111000-00006.Peer-Reviewed Original ResearchConceptsInpatient resource utilizationClozapine treatmentInpatient daysComparison groupService utilization variablesMore inpatient daysClozapine prescriptionIndex dischargeRefractory schizophreniaConventional neurolepticsTypical neurolepticsClinical variablesVA databasesInpatient hospitalizationInpatient careYear treatmentUtilization variablesClozapineTreatmentNeurolepticsPatientsSchizophreniaNeuroleptic Use in the Treatment of Post-Traumatic Stress Disorder
Sernyak M, Kosten T, Fontana A, Rosenheck R. Neuroleptic Use in the Treatment of Post-Traumatic Stress Disorder. Psychiatric Quarterly 2001, 72: 197-213. PMID: 11467155, DOI: 10.1023/a:1010318414199.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderTreatment of PTSDNeuroleptic useOutcome studiesStress disorderSevere post-traumatic stress disorderLarge outcome studiesUse of neurolepticsNeuroleptic-treated patientsObservational outcome studyCombat-related post-traumatic stress disorderIll patientsMedication historyClinical variablesNeuroleptic prescriptionSocio-demographic characteristicsTreatment characteristicsBaseline differencesNeurolepticsPatientsSecondary analysisPTSD symptomsCombat exposureTreatmentOutpatientsUse of Pharmacy Data to Assess Quality of Pharmacotherapy for Schizophrenia in a National Health Care System
Leslie D, Rosenheck R. Use of Pharmacy Data to Assess Quality of Pharmacotherapy for Schizophrenia in a National Health Care System. Medical Care 2001, 39: 923-933. PMID: 11502950, DOI: 10.1097/00005650-200109000-00003.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAdultAntipsychotic AgentsComorbidityDelivery of Health Care, IntegratedDiagnosis, Dual (Psychiatry)FemaleGuideline AdherenceHumansMaleMental Health ServicesMiddle AgedNational Health ProgramsOutcome and Process Assessment, Health CarePatient CompliancePolypharmacyPractice Guidelines as TopicSchizophreniaUnited StatesUnited States Department of Veterans AffairsConceptsPatient Outcomes Research TeamLarger mental health systemMultiple antipsychotic medicationsAntipsychotic medicationPORT recommendationsSchizophrenia Patient Outcomes Research TeamVeterans AffairsHealth systemTotal weekly doseTreatment of schizophreniaPrescription drug recordsMental health systemHealth care systemGeneralized estimation equationsMultiple antipsychoticsNational Health SystemOlder patientsWeekly doseNational health care systemPharmacy dataComorbid depressionTreatment recommendationsDrug recordsMedicationsPatientsBuprenorphine for opiate addiction: potential economic impact
Rosenheck R, Kosten T. Buprenorphine for opiate addiction: potential economic impact. Drug And Alcohol Dependence 2001, 63: 253-262. PMID: 11418229, DOI: 10.1016/s0376-8716(00)00214-3.Peer-Reviewed Original ResearchConceptsBuprenorphine/naloxoneBuprenorphine/naloxone therapyBuprenorphine/naloxone combinationOffice-based treatmentHigh-cost patientsNet cost savingsNaloxone therapyToxicology screenMethadone clinicsNaloxone combinationNursing costsTreatment opportunitiesMultiple detoxificationsOpiate addictionNaloxoneOffice practicePatientsComparable groupsAdverse effectsMethadoneTreatmentAddictsNet savingsAddictionPerceived Needs and Service Use of Spanish Speaking Monolingual Patients Followed at a Hispanic Clinic
Diaz E, Prigerson H, Desai R, Rosenheck R. Perceived Needs and Service Use of Spanish Speaking Monolingual Patients Followed at a Hispanic Clinic. Community Mental Health Journal 2001, 37: 335-346. PMID: 11482751, DOI: 10.1023/a:1017552608517.Peer-Reviewed Original ResearchMeSH KeywordsAdultCommunication BarriersCommunity Mental Health CentersConnecticutCross-Sectional StudiesCultural DiversityEducational StatusFemaleHealth Care SurveysHealth Services, IndigenousHispanic or LatinoHumansLanguageMaleMiddle AgedNeeds AssessmentPatient CompliancePsychotropic DrugsSurveys and QuestionnairesConceptsMonolingual patientsPhysical health care providersMental health centersHealth care providersClinic patientsHealth centersAdditional interventionsCare providersService useHealth needsSociodemographic characteristicsNon-HispanicsPatientsClinicPerceived NeedsHispanicsPersistent effectsLow levelsBetter accessGreat needMedicationsMore difficultyLanguage barriersThe Effect of Institutional Fiscal Stress on the Use of Atypical Antipsychotic Medications in the Treatment of Schizophrenia
LESLIE D, ROSENHECK R. The Effect of Institutional Fiscal Stress on the Use of Atypical Antipsychotic Medications in the Treatment of Schizophrenia. The Journal Of Nervous And Mental Disease 2001, 189: 377-383. PMID: 11434638, DOI: 10.1097/00005053-200106000-00005.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseAntipsychotic AgentsBenzodiazepinesBudgetsClozapineComorbidityDepressive DisorderDrug CostsFemaleHealth Care CostsHealth FacilitiesHumansMaleMiddle AgedOlanzapinePirenzepinePractice Patterns, Physicians'Regression AnalysisRisperidoneSchizophreniaTreatment OutcomeUnited StatesUnited States Department of Veterans AffairsConceptsAtypical antipsychotic medicationsTreatment of schizophreniaAtypical antipsychoticsAntipsychotic medicationExpensive atypical antipsychotic medicationsVeterans AffairsPrescription drug recordsGeneralized estimation equationsDrug recordsPatientsReduced likelihoodAntipsychoticsMedicationsFacility characteristicsSchizophreniaAtypicalsFinal sampleTreatmentOlanzapineRisperidoneOlder Adult Patients with Both Psychiatric and Substance Abuse Disorders: Prevalence and Health Service Use
Prigerson H, Desai R, Rosenheck R. Older Adult Patients with Both Psychiatric and Substance Abuse Disorders: Prevalence and Health Service Use. Psychiatric Quarterly 2001, 72: 1-18. PMID: 11293198, DOI: 10.1023/a:1004821118214.Peer-Reviewed Original ResearchConceptsOlder adult patientsSubstance abuse disordersAdult patientsAbuse disordersService useDual diagnosisSubstance abuse visitsLonger inpatient staysHealth service useMental health careCross-sectional surveyElderly patientsPsychiatric visitsYounger patientsInpatient stayProgram patientsPatientsOlder ageSubstance abuseOlder adultsHealth careRepresentative national sampleContrast groupPrevalenceDiagnosisCross-System Service Use Among VA Mental Health Patients Living in Philadelphia
Desai R, Rosenheck R, Rothbard A. Cross-System Service Use Among VA Mental Health Patients Living in Philadelphia. Administration And Policy In Mental Health And Mental Health Services Research 2001, 28: 299-309. PMID: 11577656, DOI: 10.1023/a:1011137630558.Peer-Reviewed Original ResearchImpact of VA bed closures on use of state psychiatric services
Rosenheck R, Frisman L, Essock S. Impact of VA bed closures on use of state psychiatric services. The Journal Of Behavioral Health Services & Research 2001, 28: 58-66. PMID: 11329999, DOI: 10.1007/bf02287234.Peer-Reviewed Original ResearchConsumer Experience with Payeeship Provided by a Community Mental Health Center
Rosen M, Desai R, Bailey M, Davidson L, Rosenheck R. Consumer Experience with Payeeship Provided by a Community Mental Health Center. Psychiatric Rehabilitation Journal 2001, 25: 190-195. PMID: 11769986, DOI: 10.1037/h0095025.Peer-Reviewed Original ResearchConceptsCommunity mental health centerTherapeutic allianceMental health centersWeaker therapeutic allianceStrong therapeutic allianceMost patientsWorking Alliance InventoryHealth centersDifferent staff membersAlliance InventoryAlliance scoresClinical therapistsSignificant minorityPatientsOverall satisfactionFeelings of coercionStaff membersMoney management servicesTherapists
2000
Does Closing Inpatient Beds in One Public Mental Health System Result in Increased Use of Hospital Services in Other Systems?
Rosenheck R, Banks S, Pandiani J. Does Closing Inpatient Beds in One Public Mental Health System Result in Increased Use of Hospital Services in Other Systems? Mental Health Services Research 2000, 2: 183-189. DOI: 10.1023/a:1010156318652.Peer-Reviewed Original ResearchBehavioral health servicesCross-system useState mental hospitalGeneral HospitalInpatient servicesHealth servicesMental hospitalsVA mental healthMental health bedsSubstance abuse patientsCommunity general hospitalProbabilistic population estimationNew York State residentsBehavioral health careHealth service usersVA outpatient servicesInpatient populationOutpatient servicesAbuse patientsPsychiatric patientsService useInpatient bedsHospitalPatientsHospital services