2024
National trends and correlates of treatment resistance in major depressive episode and associated suicidal ideation and behaviors among adults in the United States
Rhee T, Bommersbach T, Rosenheck R, Nierenberg A, McIntyre R. National trends and correlates of treatment resistance in major depressive episode and associated suicidal ideation and behaviors among adults in the United States. Journal Of Affective Disorders 2024, 358: 342-349. PMID: 38734245, DOI: 10.1016/j.jad.2024.05.044.Peer-Reviewed Original ResearchTreatment-resistant depressionMajor depressive episodeSuicidal ideationDepressive episodeAverage annual percent changePast-year suicide attemptPast-year suicidal ideationPast-year major depressive episodePrevalence of suicidal ideationSuicide prevention effortsNational Survey of Drug Use and HealthUS adultsSuicide attemptsDrug Use and HealthNon-pharmacological interventionsHigh-risk populationIdeationAnnual percent changeTreatment resistanceNo significant differenceDiagnostic criteriaPreventive servicesAdultsPercent changeSignificant difference
2023
Efficacy and safety of ketamine-assisted electroconvulsive therapy in major depressive episode: a systematic review and network meta-analysis
Rhee T, Shim S, Popp J, Trikalinos T, Rosenheck R, Kellner C, Seiner S, Espinoza R, Forester B, McIntyre R. Efficacy and safety of ketamine-assisted electroconvulsive therapy in major depressive episode: a systematic review and network meta-analysis. Molecular Psychiatry 2023, 29: 750-759. PMID: 38123725, DOI: 10.1038/s41380-023-02366-8.Peer-Reviewed Original ResearchMajor depressive episodeStandardized mean differenceElectroconvulsive therapyAnesthetic agentsDepressive symptomsDepressive episodeRelative riskDiagnosis of MDESystematic reviewKetamine-treated patientsSafety of ketamineSerious adverse eventsResultsTwenty-two studiesMethodsPubMed/MEDLINEImportant clinical considerationsRandom-effects modelCognitive performanceAdverse eventsAntidepressant efficacyECT useTrials RegistryClinical efficacyCochrane LibraryWorse outcomesPatient profiles