1982
The clinical behavior of „mixed”︁ small cell/large cell bronchogenic carcinoma compared to „pure”︁ small cell subtypes
Radice P, Matthews M, Ihde D, Gazdar A, Carney D, Bunn P, Cohen M, Fossieck B, Makuch R, Minna J. The clinical behavior of „mixed”︁ small cell/large cell bronchogenic carcinoma compared to „pure”︁ small cell subtypes. Cancer 1982, 50: 2894-2902. PMID: 6291745, DOI: 10.1002/1097-0142(19821215)50:12<2894::aid-cncr2820501232>3.0.co;2-g.Peer-Reviewed Original ResearchConceptsSmall cell carcinomaSmall cell subtypeCell carcinomaResponse rateCombination chemotherapyClinical behaviorLong-term disease-free survivalCentral nervous system metastasesSmall cell carcinoma casesUntreated lung cancer patientsCell subtypesSmall cell lung cancerAggressive chemotherapy protocolsDistinct pathologic variantComplete response rateNervous system metastasesCell bronchogenic carcinomaDisease-free survivalIntensive combination chemotherapySmall cell cancerExtent of diseaseLarge cell carcinomaCell lung cancerLung cancer patientsLarge cell component
1980
Influence of Histologic Subtype of Small Cell Carcinoma of the Lung on Clinical Presentation, Response to Therapy, and Survival2
Carney D, Matthews M, Ihde D, Bunn P, Cohen M, Makuch R, Gazdar A, Minna J. Influence of Histologic Subtype of Small Cell Carcinoma of the Lung on Clinical Presentation, Response to Therapy, and Survival2. Journal Of The National Cancer Institute 1980, 65: 1225-1230. PMID: 6253711, DOI: 10.1093/jnci/65.6.1225.Peer-Reviewed Original ResearchConceptsSmall cell carcinomaHistologic subtypeCell carcinomaSame patientBiopsy tissueAggressive cytotoxic therapyChemotherapeutic response rateExtent of diseaseInitial performance statusIntermediate cell subtypeSignificant differencesPerformance statusCombination chemotherapyClinical presentationCytotoxic therapyTherapeutic decisionsPatientsLung cancer classificationResponse rateCell subtypesSubtypesTherapyCarcinomaLungWorking Party