2016
Allergic Contact Dermatitis: A Model of Inflammatory Itch and Pain in Human and Mouse
LaMotte RH. Allergic Contact Dermatitis: A Model of Inflammatory Itch and Pain in Human and Mouse. Advances In Experimental Medicine And Biology 2016, 904: 23-32. PMID: 26900060, PMCID: PMC4910628, DOI: 10.1007/978-94-017-7537-3_2.Peer-Reviewed Original ResearchConceptsAllergic contact dermatitisPersistent itchPathogenesis of ACDSquaric acid dibutyl esterPain-like behaviorsSmall-diameter neuronsPeripheral neural mechanismsPossible therapeutic targetInflammatory itchPruritic disordersCutaneous sitesChemokine CXCL10Excitatory responsesLocal inflammationReceptor CXCR3Contact dermatitisUnmyelinated axonsSpontaneous activityTherapeutic targetAnimal modelsPainSubsequent challengeTopical applicationItchMice
2015
Chronic Compression of the Dorsal Root Ganglion Enhances Mechanically Evoked Pain Behavior and the Activity of Cutaneous Nociceptors in Mice
Wang T, Hurwitz O, Shimada SG, Qu L, Fu K, Zhang P, Ma C, LaMotte RH. Chronic Compression of the Dorsal Root Ganglion Enhances Mechanically Evoked Pain Behavior and the Activity of Cutaneous Nociceptors in Mice. PLOS ONE 2015, 10: e0137512. PMID: 26356638, PMCID: PMC4565551, DOI: 10.1371/journal.pone.0137512.Peer-Reviewed Original ResearchConceptsDorsal root gangliaPunctate mechanical stimuliSpontaneous activityChronic compressionCutaneous nociceptorsL3 dorsal root gangliaPost-operative day 2Evoked pain behaviorsPain-like behaviorsVon Frey filamentsDorsum of footUnoperated control miceMechanical stimuliCutaneous C nociceptorsBehavioral hyperalgesiaCCD surgeryIntraforaminal stenosisMechanical allodyniaRadicular painC-nociceptorsDRG neuronsPain behaviorControl miceEnhanced excitabilityControl neurons
2014
Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain
Qu L, Fan N, Ma C, Wang T, Han L, Fu K, Wang Y, Shimada SG, Dong X, LaMotte RH. Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain. Brain 2014, 137: 1039-1050. PMID: 24549959, PMCID: PMC3959553, DOI: 10.1093/brain/awu007.Peer-Reviewed Original ResearchConceptsContact hypersensitivityPruriceptive neuronsEnhanced excitabilityNervous systemNociceptive dorsal root ganglion (DRG) neuronsSodium currentVehicle-treated control animalsDorsal root ganglion neuronsSquaric acid dibutyl esterItch-like behaviorsPain-related behaviorsResistant sodium currentsAllergic contact dermatitisAction potential activityWhole-cell recordingsInflammatory itchPersistent itchPruritic disordersSpontaneous itchSpontaneous scratchingAcute itchNeuronal hyperexcitabilityNociceptive neuronsPruritic diseasesCommon symptoms
2012
A subpopulation of nociceptors specifically linked to itch
Han L, Ma C, Liu Q, Weng HJ, Cui Y, Tang Z, Kim Y, Nie H, Qu L, Patel KN, Li Z, McNeil B, He S, Guan Y, Xiao B, LaMotte RH, Dong X. A subpopulation of nociceptors specifically linked to itch. Nature Neuroscience 2012, 16: 174-182. PMID: 23263443, PMCID: PMC3557753, DOI: 10.1038/nn.3289.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsAntirheumatic AgentsCalciumCapsaicinCells, CulturedChloroquineEpidermisGanglia, SpinalGene Expression RegulationGreen Fluorescent ProteinsHistamineHot TemperatureMaleMiceMice, Inbred C57BLMice, TransgenicMotor ActivityNerve FibersNerve Tissue ProteinsNociceptorsPain MeasurementPain ThresholdPatch-Clamp TechniquesPeptide FragmentsPlant LectinsProteinsProto-Oncogene Proteins c-fosPruritusReceptors, BombesinReceptors, G-Protein-CoupledRNA, UntranslatedRotarod Performance TestSensory Receptor CellsSensory System AgentsSpinal CordTRPV Cation Channels
2006
MCP-1 Enhances Excitability of Nociceptive Neurons in Chronically Compressed Dorsal Root Ganglia
Sun J, Yang B, Donnelly D, Ma C, LaMotte R. MCP-1 Enhances Excitability of Nociceptive Neurons in Chronically Compressed Dorsal Root Ganglia. Journal Of Neurophysiology 2006, 96: 2189-2199. PMID: 16775210, DOI: 10.1152/jn.00222.2006.Peer-Reviewed Original ResearchConceptsMonocyte chemoattractant protein-1Dorsal root gangliaNociceptive neuronsRoot gangliaCompressed dorsal root ganglionIntact dorsal root gangliaSmall DRG neuronsProportion of neuronsChemoattractant protein-1Action potential widthNonselective cation conductanceMagnitude of depolarizationCCD neuronsChronic compressionDRG neuronsExcitatory effectsReceptor CCR2Nociceptive propertiesIntact gangliaNeuronal expressionInward currentsNeuronsCurrent clampGangliaReversal potential
2002
Comparison of responses to tensile and compressive stimuli in C-mechanosensitive nociceptors in rat hairy skin
Zheng Z, LaMotte R, Grigg P. Comparison of responses to tensile and compressive stimuli in C-mechanosensitive nociceptors in rat hairy skin. Somatosensory & Motor Research 2002, 19: 109-113. PMID: 12088384, DOI: 10.1080/08990220120113095.Peer-Reviewed Original Research
1997
Tensile and Compressive Responses of Nociceptors in Rat Hairy Skin
Khalsa P, Lamotte R, Grigg P. Tensile and Compressive Responses of Nociceptors in Rat Hairy Skin. Journal Of Neurophysiology 1997, 78: 492-505. PMID: 9242296, DOI: 10.1152/jn.1997.78.1.492.Peer-Reviewed Original ResearchConceptsCompressive stressCompressive loadingTensile stressApplied loadFlat indenter tipCompressive responseIndenter tipCompressive loadTensile loadSurface displacementsTip excursionCompressive strainForce controlTensile strainTip geometrySoft substratesLoadingLoadTensile stimulusHard substratesSubstrateStressIndentationCompressionUniform state
1993
Effect of protons on the inward current evoked by capsaicin in isolated dorsal root ganglion cells
Petersen M, LaMotte R. Effect of protons on the inward current evoked by capsaicin in isolated dorsal root ganglion cells. Pain 1993, 54: 37-42. PMID: 7690929, DOI: 10.1016/0304-3959(93)90097-9.Peer-Reviewed Original ResearchConceptsInward currentsDorsal root ganglion neuronsDorsal root ganglion cellsCapsaicin-evoked currentsWhole-cell voltage-clamp conditionsImportant modulatory roleVoltage-clamp conditionsDRG cellsGanglion neuronsGanglion cellsSensory neuronsModulatory roleCapsaicinProgressive decreaseNeuronsCellsExtracellular medium
1992
Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin.
LaMotte R, Lundberg L, Torebjörk H. Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin. The Journal Of Physiology 1992, 448: 749-764. PMID: 1593488, PMCID: PMC1176226, DOI: 10.1113/jphysiol.1992.sp019068.Peer-Reviewed Original ResearchConceptsDuration of painMagnitude of painC-nociceptorsCapsaicin injectionMechanical hyperalgesiaIntradermal injectionTopical applicationReceptive fieldsC-mechanoheat nociceptorsEffects of capsaicinMean discharge rateCutaneous hyperalgesiaHyperalgesic areaUnchanged responsivenessBackground painAlgesic substancesPeroneal nerveNociceptor excitabilityNociceptor responsesPain thresholdMechanical stimuliNociceptor dischargeIntense painConcomitant painAwake humans
1991
Neurogenic hyperalgesia: the search for the primary cutaneous afferent fibers that contribute to capsaicin-induced pain and hyperalgesia
Baumann T, Simone D, Shain C, LaMotte R. Neurogenic hyperalgesia: the search for the primary cutaneous afferent fibers that contribute to capsaicin-induced pain and hyperalgesia. Journal Of Neurophysiology 1991, 66: 212-227. PMID: 1919668, DOI: 10.1152/jn.1991.66.1.212.Peer-Reviewed Original ResearchConceptsAfferent fibersNeurogenic hyperalgesiaPrimary hyperalgesiaNociceptive fibersPrimary afferentsIntradermal injectionHeat stimuliInjection siteReceptive fieldsCutaneous primary afferent fibersCapsaicin injection siteCutaneous afferent fibersNociceptive afferent fibersInjection of capsaicinCapsaicin-induced painPrimary afferent fibersPeripheral nervous systemPeripheral neural mechanismsArea of skinCapsaicin painSecondary hyperalgesiaDepressed responsivenessCapsaicin injectionIntense painHyperalgesia
1988
Chapter 39 Psychophysical and neurophysiological studies of chemically induced cutaneous pain and itch The case of the missing nociceptor
LaMotte R. Chapter 39 Psychophysical and neurophysiological studies of chemically induced cutaneous pain and itch The case of the missing nociceptor. Progress In Brain Research 1988, 74: 331-335. PMID: 3187041, DOI: 10.1016/s0079-6123(08)63033-2.Peer-Reviewed Original ResearchConceptsCutaneous painInjection siteNeurophysiological studiesPeripheral nerve fibersSensation of painCapsaicin painInjection painMechanical hyperesthesiaHeat hyperalgesiaHeat nociceptorsIntradermal injectionCutaneous receptorsNerve fibersHistamine dihydrochloridePainNociceptorsCapsaicinGreater painItchAllodyniaHyperesthesiaFurther investigationCandidate mechanismInjectionSensation
1984
Time-intensity profiles of cutaneous pain in normal and hyperalgesic skin: a comparison with C-fiber nociceptor activities in monkey and human
LaMotte R, Torebjörk H, Robinson C, Thalhammer J. Time-intensity profiles of cutaneous pain in normal and hyperalgesic skin: a comparison with C-fiber nociceptor activities in monkey and human. Journal Of Neurophysiology 1984, 51: 1434-1450. PMID: 6737035, DOI: 10.1152/jn.1984.51.6.1434.Peer-Reviewed Original ResearchConceptsNociceptive afferent fibersDevelopment of hyperalgesiaConditioning stimulusPain ratingsHeat stimulationAfferent fibersHairy skinHeat-evoked dischargesCervical spinal cordMagnitude of painMild heat injurySimilar response magnitudesMean frequencyPoststimulus time histogramsNociceptor activityCutaneous painResponse latencyHyperalgesic skinSpinal cordAwake humansC-fibersAnesthetized monkeysConduction velocityPainHeat stimuliPeripheral neural correlates of magnitude of cutaneous pain and hyperalgesia: simultaneous recordings in humans of sensory judgments of pain and evoked responses in nociceptors with C-fibers
Torebjörk H, LaMotte R, Robinson C. Peripheral neural correlates of magnitude of cutaneous pain and hyperalgesia: simultaneous recordings in humans of sensory judgments of pain and evoked responses in nociceptors with C-fibers. Journal Of Neurophysiology 1984, 51: 325-339. PMID: 6707724, DOI: 10.1152/jn.1984.51.2.325.Peer-Reviewed Original ResearchConceptsConditioning stimulusIntensity-response functionsNormal skinMost subjectsC-mechanoheat nociceptorsPeripheral neural correlateHeat pain sensationMild heat injuryMagnitude ratingsReceptive fieldsHeat injurySupra-threshold stimuliShort-duration stimuliPain thresholdCutaneous painHeat painPain sensationC-fibersPainNociceptorsHairy skinUninjured skinHeat stimulationMagnitude of responseNeuronal correlates
1983
Psychophysical detection and pain ratings of incremental thermal stimuli: A comparison with nociceptor responses in humans
Robinson C, Torebjörk H, LaMotte R. Psychophysical detection and pain ratings of incremental thermal stimuli: A comparison with nociceptor responses in humans. Brain Research 1983, 274: 87-106. PMID: 6616259, DOI: 10.1016/0006-8993(83)90523-1.Peer-Reviewed Original ResearchConceptsMagnitude of painThermal stimuliContact thermal stimulatorMost nociceptorsNociceptive afferentsPeroneal nerveNociceptor responsesPain magnitudePain ratingsPain sensitivityPain sensationUnmyelinated fibersPainNormal skinMild burnsPsychophysical detectionDegrees CNeural responsesNociceptorsAfferentsThermal stimulatorCapacity of humansIncrement detectionDegrees C.Detection thresholdPeripheral neural correlates of magnitude of cutaneous pain and hyperalgesia: a comparison of neural events in monkey with sensory judgments in human
LaMotte R, Thalhammer J, Robinson C. Peripheral neural correlates of magnitude of cutaneous pain and hyperalgesia: a comparison of neural events in monkey with sensory judgments in human. Journal Of Neurophysiology 1983, 50: 1-26. PMID: 6875640, DOI: 10.1152/jn.1983.50.1.1.Peer-Reviewed Original Research
1982
Response properties of high-threshold cutaneous cold receptors in the primate
LaMotte R, Thalhammer J. Response properties of high-threshold cutaneous cold receptors in the primate. Brain Research 1982, 244: 279-287. PMID: 7116176, DOI: 10.1016/0006-8993(82)90086-5.Peer-Reviewed Original ResearchPeripheral neural mechanisms of cutaneous hyperalgesia following mild injury by heat
LaMotte R, Thalhammer J, Torebjörk H, Robinson C. Peripheral neural mechanisms of cutaneous hyperalgesia following mild injury by heat. Journal Of Neuroscience 1982, 2: 765-781. PMID: 7086482, PMCID: PMC6564351, DOI: 10.1523/jneurosci.02-06-00765.1982.Peer-Reviewed Original ResearchConceptsConditioning stimulusCutaneous hyperalgesiaMild injuryDevelopment of hyperalgesiaHeat injuryMagnitude of hyperalgesiaMild heat injurySingle conditioning stimulusMagnitude of sensitizationPeripheral neural mechanismsReceptive fieldsPeroneal nervePeripheral determinantsCutaneous receptorsC-fibersAwake humansConduction blockAnesthetized monkeysHyperalgesiaNociceptorsPainGlabrous skinNormal skinInjuryHeat stimulationSpatial properties of nociceptor sensitization following heat injury of the skin
Thalhammer J, LaMotte R. Spatial properties of nociceptor sensitization following heat injury of the skin. Brain Research 1982, 231: 257-265. PMID: 7055680, DOI: 10.1016/0006-8993(82)90364-x.Peer-Reviewed Original Research