1996
Reduction of Postburn Hyperalgesia after Local Injection of Ketorolac in Healthy Volunteers
Lundell J, Silverman D, Brull S, O'Connor T, Kitahata L, Collins J, LaMotte R. Reduction of Postburn Hyperalgesia after Local Injection of Ketorolac in Healthy Volunteers. Anesthesiology 1996, 84: 502-509. PMID: 8659776, DOI: 10.1097/00000542-199603000-00003.Peer-Reviewed Original ResearchConceptsHealthy volunteersEffect of pretreatmentNonsteroidal antiinflammatory drugsSystemic side effectsBradykinin-induced hyperalgesiaContact thermal stimulatorRepeated-measures analysisInflammatory painBradykinin injectionPain intensityPain thresholdAntiinflammatory drugsLocal injectionHyperalgesiaSide effectsKetorolacDrug AdministrationPainMild burnsThermal stimuliThermal stimulatorInjurySelective effectInjectionSaline
1984
Time-intensity profiles of cutaneous pain in normal and hyperalgesic skin: a comparison with C-fiber nociceptor activities in monkey and human
LaMotte R, Torebjörk H, Robinson C, Thalhammer J. Time-intensity profiles of cutaneous pain in normal and hyperalgesic skin: a comparison with C-fiber nociceptor activities in monkey and human. Journal Of Neurophysiology 1984, 51: 1434-1450. PMID: 6737035, DOI: 10.1152/jn.1984.51.6.1434.Peer-Reviewed Original ResearchConceptsNociceptive afferent fibersDevelopment of hyperalgesiaConditioning stimulusPain ratingsHeat stimulationAfferent fibersHairy skinHeat-evoked dischargesCervical spinal cordMagnitude of painMild heat injurySimilar response magnitudesMean frequencyPoststimulus time histogramsNociceptor activityCutaneous painResponse latencyHyperalgesic skinSpinal cordAwake humansC-fibersAnesthetized monkeysConduction velocityPainHeat stimuli