2015
Psychophysical Measurements of Itch and Nociceptive Sensations in an Experimental Model of Allergic Contact Dermatitis
Pall PS, Hurwitz OE, King BA, LaMotte RH. Psychophysical Measurements of Itch and Nociceptive Sensations in an Experimental Model of Allergic Contact Dermatitis. Journal Of Pain 2015, 16: 741-749. PMID: 26002605, PMCID: PMC4522332, DOI: 10.1016/j.jpain.2015.04.009.Peer-Reviewed Original ResearchConceptsSquaric acid dibutyl esterAllergic contact dermatitisSpontaneous itchContact dermatitisNociceptive sensationsT cell-mediated inflammationExperimental modelPeripheral neural activityQuality of lifeInflammatory itchBAM8-22Skin inflammationHypersensitivity reactionsPain sensationAllergen resultsIntradermal injectionCommon conditionHealthy volunteersPotential treatmentItchPsychophysical measurementsInflammationVolar forearmDermatitisNeural activity
2012
A subpopulation of nociceptors specifically linked to itch
Han L, Ma C, Liu Q, Weng HJ, Cui Y, Tang Z, Kim Y, Nie H, Qu L, Patel KN, Li Z, McNeil B, He S, Guan Y, Xiao B, LaMotte RH, Dong X. A subpopulation of nociceptors specifically linked to itch. Nature Neuroscience 2012, 16: 174-182. PMID: 23263443, PMCID: PMC3557753, DOI: 10.1038/nn.3289.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsAntirheumatic AgentsCalciumCapsaicinCells, CulturedChloroquineEpidermisGanglia, SpinalGene Expression RegulationGreen Fluorescent ProteinsHistamineHot TemperatureMaleMiceMice, Inbred C57BLMice, TransgenicMotor ActivityNerve FibersNerve Tissue ProteinsNociceptorsPain MeasurementPain ThresholdPatch-Clamp TechniquesPeptide FragmentsPlant LectinsProteinsProto-Oncogene Proteins c-fosPruritusReceptors, BombesinReceptors, G-Protein-CoupledRNA, UntranslatedRotarod Performance TestSensory Receptor CellsSensory System AgentsSpinal CordTRPV Cation Channels
1999
Mechanical and Thermal Hyperalgesia and Ectopic Neuronal Discharge After Chronic Compression of Dorsal Root Ganglia
Song X, Hu S, Greenquist K, Zhang J, LaMotte R. Mechanical and Thermal Hyperalgesia and Ectopic Neuronal Discharge After Chronic Compression of Dorsal Root Ganglia. Journal Of Neurophysiology 1999, 82: 3347-3358. PMID: 10601466, DOI: 10.1152/jn.1999.82.6.3347.Peer-Reviewed Original ResearchConceptsDorsal root gangliaChronic compressionAcute injuryRoot gangliaPreoperative valuesPostoperative testingFoot withdrawalSpontaneous dischargeIntact sympathetic nervous systemUnmyelinated peripheral nerve fibersEctopic neuronal dischargesEctopic spontaneous dischargesSympathetic nervous systemLow back painPeripheral nerve fibersDorsal root fibersBlood-borne chemicalsExtracellular electrophysiological recordingsActive myelinated fibersCotton wispNonsurgical ratsMechanical hyperalgesiaEctopic dischargesThermal hyperalgesiaBack painEnhanced Excitability of Sensory Neurons in Rats With Cutaneous Hyperalgesia Produced by Chronic Compression of the Dorsal Root Ganglion
Zhang J, Song X, LaMotte R. Enhanced Excitability of Sensory Neurons in Rats With Cutaneous Hyperalgesia Produced by Chronic Compression of the Dorsal Root Ganglion. Journal Of Neurophysiology 1999, 82: 3359-3366. PMID: 10601467, DOI: 10.1152/jn.1999.82.6.3359.Peer-Reviewed Original ResearchConceptsDorsal root gangliaControl ratsCutaneous hyperalgesiaDRG cellsRoot gangliaSpontaneous activityChronic mechanical compressionCCD cellsAction potential thresholdDRG somataChronic compressionChronic painContralateral footSham operationElectrophysiological changesSpinal injuryIntracellular recordingsPunctate stimulationSensory pathologySensory neuronsIntervertebral foraminaIntrinsic alterationsElectrophysiological propertiesPlantar surfaceHyperalgesia