2015
Chronic Compression of the Dorsal Root Ganglion Enhances Mechanically Evoked Pain Behavior and the Activity of Cutaneous Nociceptors in Mice
Wang T, Hurwitz O, Shimada SG, Qu L, Fu K, Zhang P, Ma C, LaMotte RH. Chronic Compression of the Dorsal Root Ganglion Enhances Mechanically Evoked Pain Behavior and the Activity of Cutaneous Nociceptors in Mice. PLOS ONE 2015, 10: e0137512. PMID: 26356638, PMCID: PMC4565551, DOI: 10.1371/journal.pone.0137512.Peer-Reviewed Original ResearchConceptsDorsal root gangliaPunctate mechanical stimuliSpontaneous activityChronic compressionCutaneous nociceptorsL3 dorsal root gangliaPost-operative day 2Evoked pain behaviorsPain-like behaviorsVon Frey filamentsDorsum of footUnoperated control miceMechanical stimuliCutaneous C nociceptorsBehavioral hyperalgesiaCCD surgeryIntraforaminal stenosisMechanical allodyniaRadicular painC-nociceptorsDRG neuronsPain behaviorControl miceEnhanced excitabilityControl neurons
2006
MCP-1 Enhances Excitability of Nociceptive Neurons in Chronically Compressed Dorsal Root Ganglia
Sun J, Yang B, Donnelly D, Ma C, LaMotte R. MCP-1 Enhances Excitability of Nociceptive Neurons in Chronically Compressed Dorsal Root Ganglia. Journal Of Neurophysiology 2006, 96: 2189-2199. PMID: 16775210, DOI: 10.1152/jn.00222.2006.Peer-Reviewed Original ResearchConceptsMonocyte chemoattractant protein-1Dorsal root gangliaNociceptive neuronsRoot gangliaCompressed dorsal root ganglionIntact dorsal root gangliaSmall DRG neuronsProportion of neuronsChemoattractant protein-1Action potential widthNonselective cation conductanceMagnitude of depolarizationCCD neuronsChronic compressionDRG neuronsExcitatory effectsReceptor CCR2Nociceptive propertiesIntact gangliaNeuronal expressionInward currentsNeuronsCurrent clampGangliaReversal potential
1999
Plasticity of sodium channel expression in DRG neurons in the chronic constriction injury model of neuropathic pain
Dib-Hajj S, Fjell J, Cummins TR, Zheng Z, Fried K, LaMotte R, Black JA, Waxman S. Plasticity of sodium channel expression in DRG neurons in the chronic constriction injury model of neuropathic pain. Pain 1999, 83: 591-600. PMID: 10568868, DOI: 10.1016/s0304-3959(99)00169-4.Peer-Reviewed Original ResearchConceptsTTX-R sodium channelsChronic constriction injury modelDRG neuronsSodium currentSodium channelsNeuropathic painInjury modelAxotomized dorsal root ganglion (DRG) neuronsSmall-diameter DRG neuronsTTX-R sodium currentsDorsal root ganglion neuronsTTX-S currentsSodium channel expressionGanglion neuronsSciatic nerveChannel expressionSodium channel transcriptsNeuronsNa currentPainChannel transcriptsSignificant changesLevels of transcriptsHyperalgesiaPrevious studies
1997
An in vitro study of ectopic discharge generation and adrenergic sensitivity in the intact, nerve-injured rat dorsal root ganglion
Zhang J, Song X, LaMotte R. An in vitro study of ectopic discharge generation and adrenergic sensitivity in the intact, nerve-injured rat dorsal root ganglion. Pain 1997, 72: 51-57. PMID: 9272787, DOI: 10.1016/s0304-3959(97)00013-4.Peer-Reviewed Original ResearchConceptsDorsal root gangliaNerve-injured ratsAdrenergic sensitivitySpontaneous activityUninjured nerveDRG cellsRoot gangliaSciatic nerveL5 dorsal root gangliaIntact dorsal root gangliaSelective alpha2-adrenergic agonistRat dorsal root gangliaAbnormal spontaneous activityInjured DRG neuronsSympathetic nervous systemAlpha2-adrenergic agonistDorsal root fibersIntact blood circulationCutaneous hyperalgesiaSpontaneous painDRG neuronsDorsal rootsSpontaneous dischargeC-fibersPeripheral axons