2022
Longitudinal analysis of the prevalence and correlates of heavy episodic drinking and self‐reported opioid use among a national cohort of patients with HIV
Oldfield BJ, Li Y, Vickers‐Smith R, Barry DT, Crystal S, Gordon KS, Kerns RD, Williams EC, Marshall BDL, Edelman EJ. Longitudinal analysis of the prevalence and correlates of heavy episodic drinking and self‐reported opioid use among a national cohort of patients with HIV. Alcohol Clinical And Experimental Research 2022, 46: 600-613. PMID: 35257397, PMCID: PMC9018502, DOI: 10.1111/acer.14801.Peer-Reviewed Original ResearchConceptsSelf-reported opioid useOpioid useHeavy episodic drinkingNational cohortRisk factorsDepressive symptomsVeterans Aging Cohort StudyVeterans Health Administration sitesOpioid-related risksHIV disease progressionModifiable risk factorsPast-year cigarette smokingAging Cohort StudyGreater illness severityEpisodic drinkingOpioid-related overdoseHigh-risk drinkingCohort studyProspective cohortIllness severityCigarette smokingClinical correlatesDisease progressionLower oddsMultinomial logistic regression
2021
Sociodemographic and clinical correlates of gabapentin receipt with and without opioids among a national cohort of patients with HIV
Oldfield BJ, Li Y, Vickers-Smith R, Becker WC, Barry DT, Crystal S, Gordon KS, Kerns RD, Rentsch CT, Marshall BDL, Edelman EJ. Sociodemographic and clinical correlates of gabapentin receipt with and without opioids among a national cohort of patients with HIV. AIDS Care 2021, 34: 1053-1063. PMID: 34114904, PMCID: PMC8664891, DOI: 10.1080/09540121.2021.1939851.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidChronic PainCohort StudiesGabapentinHIV InfectionsHumansOpioid-Related DisordersProspective StudiesConceptsOpioid useHigh dosesSelf-reported opioid useVeterans Aging Cohort StudyHigh-dose opioidsMean daily doseAging Cohort StudyHigh-dose benzodiazepinesNational prospective cohortOpioid doseOpioid receiptCohort studyFoot painProspective cohortDaily doseIndependent predictorsChronic painPain interferenceClinical variablesClinical correlatesNational cohortMultinomial logistic regressionPWHLogistic regressionOpioids
2020
All-cause mortality among males living with and without HIV initiating long-term opioid therapy, and its association with opioid dose, opioid interruption and other factors
Gordon K, Manhapra A, Crystal S, Dziura J, Edelman E, Skanderson M, Kerns R, Justice A, Tate J, Becker W. All-cause mortality among males living with and without HIV initiating long-term opioid therapy, and its association with opioid dose, opioid interruption and other factors. Drug And Alcohol Dependence 2020, 216: 108291. PMID: 33011662, PMCID: PMC7644145, DOI: 10.1016/j.drugalcdep.2020.108291.Peer-Reviewed Original ResearchConceptsMorphine equivalent daily doseCause mortalityLong-term opioid therapyTime-updated Cox regressionStrong dose-response relationshipUnnatural deathsEquivalent daily doseDose-response relationshipOpioid doseOpioid therapyUninfected patientsOpioid useDaily doseCox regressionMortality outcomesTherapy doseHigh doseMale veteransOverdose fatalitiesOverdose mortalityPLWHMortalityHIVPatientsDose
2019
High-dose prescribed opioids are associated with increased risk of heroin use among United States military veterans.
Banerjee G, Edelman EJ, Barry DT, Crystal S, Gordon KS, Gordon AJ, Gaither JR, Green TC, Kerns RD, Manhapra A, Moore BA, Fiellin DA, Marshall BDL. High-dose prescribed opioids are associated with increased risk of heroin use among United States military veterans. Pain 2019, 160: 2126-2135. PMID: 31145217, PMCID: PMC6699915, DOI: 10.1097/j.pain.0000000000001606.Peer-Reviewed Original ResearchConceptsHigh-dose opioid prescriptionsOpioid prescriptionsHeroin useCohort studyPrior receiptHepatitis C virus (HCV) infection statusLong-term opioid prescriptionsPast-year heroin useVeterans Aging Cohort StudyHigh-dose opioidsOpioid-prescribing patternsProspective cohort studyAging Cohort StudyOpioid use disorderCurrent national guidelinesUnhealthy alcohol useUnited States veteransUnited States military veteransVirus infection statusPosttraumatic stress disorderOpioid receiptPrescribed opioidsPain interferenceCox regressionStates veterans
2018
Duration of opioid prescriptions predicts incident nonmedical use of prescription opioids among U.S. veterans receiving medical care
Barry DT, Marshall BDL, Becker WC, Gordon AJ, Crystal S, Kerns RD, Gaither JR, Gordon KS, Justice AC, Fiellin DA, Edelman EJ. Duration of opioid prescriptions predicts incident nonmedical use of prescription opioids among U.S. veterans receiving medical care. Drug And Alcohol Dependence 2018, 191: 348-354. PMID: 30176548, PMCID: PMC6596307, DOI: 10.1016/j.drugalcdep.2018.07.008.Peer-Reviewed Original ResearchConceptsPrescription opioid receiptPrescription opioidsMedical careOpioid receiptVeterans Health Administration primary careNonmedical useMultivariable Cox modelInfectious disease clinicProspective cohort studyProportional hazards regressionPrescription opioid medicationsPublic health problemSubstance use disordersMedication-related characteristicsOpioid therapyOpioid medicationsOpioid prescriptionsCohort studyDisease clinicMedian ageHazards regressionEligible participantsPrimary careRisk factorsIncidence rate
2016
Non‐medical use of prescription opioids is associated with heroin initiation among US veterans: a prospective cohort study
Banerjee G, Edelman EJ, Barry DT, Becker WC, Cerdá M, Crystal S, Gaither JR, Gordon AJ, Gordon KS, Kerns RD, Martins SS, Fiellin DA, Marshall BD. Non‐medical use of prescription opioids is associated with heroin initiation among US veterans: a prospective cohort study. Addiction 2016, 111: 2021-2031. PMID: 27552496, PMCID: PMC5056813, DOI: 10.1111/add.13491.Peer-Reviewed Original ResearchConceptsMultivariable Cox regression modelsNon-medical useCox regression modelHeroin initiationPrescription opioidsHeroin useCohort studyUS veteransOpioid use disorder diagnosisVeterans Aging Cohort StudyProspective cohort studyAging Cohort StudyIllicit opioid usePrimary care clinicsPrimary outcome measureStrong risk factorPost-traumatic stress disorderUninfected veteransUninfected patientsOpioid useRegression modelsCare clinicsPain interferencePrior diagnosisPrimary exposurePain Psychology: A Global Needs Assessment and National Call to Action
Darnall BD, Scheman J, Davin S, Burns JW, Murphy JL, Wilson AC, Kerns RD, Mackey SC. Pain Psychology: A Global Needs Assessment and National Call to Action. Pain Medicine 2016, 17: 250-263. PMID: 26803844, PMCID: PMC4758272, DOI: 10.1093/pm/pnv095.Peer-Reviewed Original ResearchConceptsPain psychologyPsychology training programsPsychological treatment modalitiesDirectors of graduatePsychology servicesPsychology curriculumQualified therapistsPsychologyPain trainingNational Pain StrategyPhysical painTherapistsPostdoctoral educationTraining programUnanimous interestLow confidenceTrainingNeeds assessmentTreatment of painPoor insurance coverageHealth care cliniciansInstitute of MedicineLimited awarenessBetter trainingPain strategiesAssociation of Pain With Physical Function, Depressive Symptoms, Fatigue, and Sleep Quality Among Veteran and non-Veteran Postmenopausal Women
Patel KV, Cochrane BB, Turk DC, Bastian LA, Haskell SG, Woods NF, Zaslavsky O, Wallace RB, Kerns RD. Association of Pain With Physical Function, Depressive Symptoms, Fatigue, and Sleep Quality Among Veteran and non-Veteran Postmenopausal Women. The Gerontologist 2016, 56: s91-s101. PMID: 26768395, PMCID: PMC5881612, DOI: 10.1093/geront/gnv670.Peer-Reviewed Original ResearchConceptsExtreme pain interferencePain interferencePhysical functionPain severitySleep qualityDepressive symptomsHealth initiativesStudy participantsWorse physical functionAssociation of painWomen's Health InitiativeNon-veteran womenObservational study participantsLimited physical functioningVeteran statusHealth care servicesPostmenopausal womenLess painPhysical functioningOlder veteransHigh incidencePainCare servicesNumber of womenComorbid symptoms
2015
Long-term Prescription of Opioids and/or Benzodiazepines and Mortality Among HIV-Infected and Uninfected Patients
Weisberg DF, Gordon KS, Barry DT, Becker WC, Crystal S, Edelman EJ, Gaither J, Gordon AJ, Goulet J, Kerns RD, Moore BA, Tate J, Justice AC, Fiellin DA. Long-term Prescription of Opioids and/or Benzodiazepines and Mortality Among HIV-Infected and Uninfected Patients. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2015, 69: 223-233. PMID: 26009831, PMCID: PMC4446730, DOI: 10.1097/qai.0000000000000591.Peer-Reviewed Original ResearchConceptsLong-term opioidsMorphine equivalent daily doseOpioid receiptRisk of deathLong-term prescriptionUninfected patientsOpioid dosesAntiretroviral therapyHazard ratioDaily dosePropensity scoreHigher opioid dosesCause mortalityHIV statusAvailable patientsMortality riskOpioidsHIVPatientsProspective analysisMortalityBenzodiazepinesDosesDeathRisk
2009
Mood and Attitude Predict Pain Outcomes Following Arthroscopic Knee Surgery
Rosenberger PH, Kerns R, Jokl P, Ickovics JR. Mood and Attitude Predict Pain Outcomes Following Arthroscopic Knee Surgery. Annals Of Behavioral Medicine 2009, 37: 70-76. PMID: 19169766, DOI: 10.1007/s12160-008-9078-z.Peer-Reviewed Original ResearchConceptsArthroscopic knee surgeryPain severityPain outcomesPain interferenceKnee surgeryBody mass indexExtent of osteoarthritisPreoperative moodPreoperative depressionKnee osteoarthritisMass indexClinical variablesSurgeryDaily functioningSeveritySignificant predictorsLongitudinal studyPainRegression analysisOsteoarthritisOutcomesImportant predictorDepressionPotential relationshipImportant outcomes
2002
Pain-Related Disability Among Older Male Veterans Receiving Primary Care
Reid MC, Guo Z, Towle VR, Kerns RD, Concato J. Pain-Related Disability Among Older Male Veterans Receiving Primary Care. The Journals Of Gerontology Series A 2002, 57: m727-m732. PMID: 12403801, DOI: 10.1093/gerona/57.11.m727.Peer-Reviewed Original ResearchConceptsPain-related disabilityHigh pain-related disabilityPresence of painOlder male veteransPain intensityPrimary careDepressive symptomsMale veteransModerate pain-related disabilityOlder personsVeterans Affairs primary care clinicsEpidemiologic Studies Depression ScaleNumeric rating scalePrimary care clinicsLow back painCross-sectional studyMost daysPain characteristicsOne-unit increaseBack painCare clinicsSubstantial disabilityModifiable factorsOlder veteransPainSelf-appraised problem solving and pain-relevant social support as predictors of the experience of chronic pain
Kerns RD, Rosenberg R, Otis JD. Self-appraised problem solving and pain-relevant social support as predictors of the experience of chronic pain. Annals Of Behavioral Medicine 2002, 24: 100-105. PMID: 12054314, DOI: 10.1207/s15324796abm2402_06.Peer-Reviewed Original ResearchConceptsChronic pain patientsPain patientsComprehensive pain management programSocial supportPain management programPrediction of painUtility of interventionsChronic painDepressive symptomsPainDepressionDisabilityPatientsMultiple regression analysisSelf-appraised problemSelf-report measuresHierarchical multiple regression analysisHigh levelsSymptomsManagement program