2022
Partnering with patients in clinical trials of pain treatments: a narrative review
Holzer KJ, Veasley C, Kerns RD, Edwards RR, Gewandter JS, Langford DJ, Yaeger LH, McNicol E, Ferguson M, Turk DC, Dworkin RH, Haroutounian S. Partnering with patients in clinical trials of pain treatments: a narrative review. Pain 2022, 163: 1862-1873. PMID: 35297799, DOI: 10.1097/j.pain.0000000000002600.Peer-Reviewed Original ResearchConceptsPain treatmentClinical trialsPatient engagementNarrative reviewClinical researchPatient-centered clinical researchPain research studiesPain-related studiesMeaningful patient engagementClinical studiesPatient recruitmentPatient partnersPatientsTrialsTreatmentCurrent evaluationReviewSpecific guidance
2021
The ACTTION Guide to Clinical Trials of Pain Treatments, part II: mitigating bias, maximizing value
Dworkin RH, Kerns RD, McDermott MP, Turk DC, Veasley C. The ACTTION Guide to Clinical Trials of Pain Treatments, part II: mitigating bias, maximizing value. PAIN Reports 2021, 6: e886. PMID: 33521484, PMCID: PMC7838005, DOI: 10.1097/pr9.0000000000000886.Peer-Reviewed Original ResearchIncorporating walking into cognitive behavioral therapy for chronic pain: safety and effectiveness of a personalized walking intervention
Heapy AA, Tankha H, Higgins DM, Driscoll M, LaChappelle KM, Goulet JL, Buta E, Piette JD, Kerns RD, Krein SL. Incorporating walking into cognitive behavioral therapy for chronic pain: safety and effectiveness of a personalized walking intervention. Journal Of Behavioral Medicine 2021, 44: 260-269. PMID: 33386530, DOI: 10.1007/s10865-020-00193-8.Peer-Reviewed Original ResearchConceptsAdverse eventsCognitive behavioral therapyChronic painBehavioral therapyCBT-CPLongstanding painWalking interventionsDaily stepsTreatment groupsPainInteractive voice responseStudy sampleWeekly goalsSignificant differencesSignificant increaseTherapyTreatmentParticipantsVoice responseSafetyPersonsBaselineWeeks
2020
Cognitive Behavioral Therapy for the Management of Multiple Sclerosis–Related Pain
Gromisch ES, Kerns RD, Czlapinski R, Beenken B, Otis J, Lo AC, Beauvais J. Cognitive Behavioral Therapy for the Management of Multiple Sclerosis–Related Pain. International Journal Of MS Care 2020, 22: 8-14. PMID: 32123523, PMCID: PMC7041614, DOI: 10.7224/1537-2073.2018-023.Peer-Reviewed Original ResearchCognitive behavioral therapyMultiple sclerosisDepressive symptom severityPain severityBehavioral therapyStandard carePain interferenceSymptom severityModerate pain severityHelpful adjunctive treatmentAdjunctive treatmentPrimary outcomeTreatment satisfactionEffective treatmentTreatment groupsPainEducation-based programsDaily functioningTherapySeverityBehavioral goalsSclerosisSignificant differencesTreatmentCare
2016
Physical activity, psychiatric distress, and interest in exercise group participation among individuals seeking methadone maintenance treatment with and without chronic pain
Beitel M, Stults-Kolehmainen M, Cutter CJ, Schottenfeld RS, Eggert K, Madden LM, Kerns RD, Liong C, Ginn J, Barry DT. Physical activity, psychiatric distress, and interest in exercise group participation among individuals seeking methadone maintenance treatment with and without chronic pain. American Journal On Addictions 2016, 25: 125-131. PMID: 26824197, DOI: 10.1111/ajad.12336.Peer-Reviewed Original ResearchConceptsMethadone maintenance treatmentPhysical activity levelsExercise group participationChronic painPhysical activityPsychiatric distressMaintenance treatmentActivity levelsPast weekVigorous-intensity physical activityExercise of patientsIntensity physical activityExercise groupExercise interventionPainBrief self-report instrumentPatientsLow levelsSelf-report instrumentDistressWeeksDepressionTreatmentGroup participationParticipantsDrug Counselors’ Attitudes Toward Nonpharmacologic Treatments for Chronic Pain
Oberleitner LM, Beitel M, Schottenfeld RS, Kerns RD, Doucette C, Napoleone R, Liong C, Barry DT. Drug Counselors’ Attitudes Toward Nonpharmacologic Treatments for Chronic Pain. Journal Of Addiction Medicine 2016, 10: 34-39. PMID: 26690289, PMCID: PMC4733570, DOI: 10.1097/adm.0000000000000177.Peer-Reviewed Original ResearchConceptsChronic painNonpharmacologic treatmentsDrug counselorsNonpharmacologic pain treatmentsMethadone-maintained patientsInterdisciplinary pain managementMethadone maintenance treatmentVulnerable patient populationCognitive behavioral therapyNonpharmacologic interventionsPain managementPain treatmentPain interventionsMaintenance treatmentPatient populationPainPatientsHerbal medicineGroup interventionEfficacyInterventionTreatmentPerceived EfficacyTherapyUndertreatment
2015
Deficiencies in reporting of statistical methodology in recent randomized trials of nonpharmacologic pain treatments: ACTTION systematic review
Dworkin JD, McKeown A, Farrar JT, Gilron I, Hunsinger M, Kerns RD, McDermott MP, Rappaport BA, Turk DC, Dworkin RH, Gewandter JS. Deficiencies in reporting of statistical methodology in recent randomized trials of nonpharmacologic pain treatments: ACTTION systematic review. Journal Of Clinical Epidemiology 2015, 72: 56-65. PMID: 26597977, DOI: 10.1016/j.jclinepi.2015.10.019.Peer-Reviewed Original ResearchConceptsRandomized clinical trialsPain treatmentPrimary analysisSystematic reviewNonpharmacologic pain treatmentsRecent randomized trialsJournal of PainQuality of reportingHalf of studiesClinical trial publicationsPercent of studiesNoninterventional trialStatistical methodsPrimary outcomeRandomized trialsClinical trialsTrial publicationsPainTrial resultsTrialsStatistical methodologyTreatmentReviewDeficiencyReportingDoes Change Occur for the Reasons We Think It Does? A Test of Specific Therapeutic Operations During Cognitive-Behavioral Treatment of Chronic Pain
Burns JW, Nielson WR, Jensen MP, Heapy A, Czlapinski R, Kerns RD. Does Change Occur for the Reasons We Think It Does? A Test of Specific Therapeutic Operations During Cognitive-Behavioral Treatment of Chronic Pain. The Clinical Journal Of Pain 2015, 31: 603-611. PMID: 25119513, DOI: 10.1097/ajp.0000000000000141.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyChronic painStandard cognitive behavioral therapyUse of painTreatment-related changesCoping skillsClinical trialsFavorable outcomeCognitive-behavioral treatmentTreatment benefitTherapeutic mechanismPatient expectationsPainWorking allianceSecondary analysisNonspecific factorsExercise useSession threeRelative validityTherapeutic operationsRelaxation skillsInventory subscalesMixed improvementsTreatmentExerciseA Systematic Review of Technology-assisted Self-Management Interventions for Chronic Pain
Heapy AA, Higgins DM, Cervone D, Wandner L, Fenton BT, Kerns RD. A Systematic Review of Technology-assisted Self-Management Interventions for Chronic Pain. The Clinical Journal Of Pain 2015, 31: 470-492. PMID: 25411862, DOI: 10.1097/ajp.0000000000000185.Peer-Reviewed Original ResearchConceptsSelf-management interventionsSystematic reviewChronic painTechnology-assisted interventionsChronic pain self-management interventionPain self-management interventionEffect of treatmentHeterogeneity of methodsNoncancer painCochrane DatabaseFuture trialsTreatment modalitiesOvid MEDLINEPerson treatmentElectronic searchPainOvid PsychInfoSuperior modalityComparison groupInteractive voice responsePsychological interventionsInterventionIndividual studiesModalitiesTreatmentSpecific and General Therapeutic Mechanisms in Cognitive Behavioral Treatment of Chronic Pain
Burns JW, Nielson WR, Jensen MP, Heapy A, Czlapinski R, Kerns RD. Specific and General Therapeutic Mechanisms in Cognitive Behavioral Treatment of Chronic Pain. Journal Of Consulting And Clinical Psychology 2015, 83: 1-11. PMID: 24979313, DOI: 10.1037/a0037208.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyPain intensityChronic painPatient expectationsPosttreatment changesPotential treatment mechanismsStandard cognitive behavioral therapyPre-post changesPain interferenceCognitive-behavioral treatmentSignificant linear trendTherapeutic mechanismDepressive symptomsDocument efficacyPainCBT conditionBehavioral treatmentBehavioral therapyComparable improvementWeeksCBT mechanismsOutcomesTreatmentSignificant quadratic trendTreatment mechanisms
2014
The Feasibility and Acceptability of Groups for Pain Management in Methadone Maintenance Treatment
Barry DT, Savant JD, Beitel M, Cutter CJ, Schottenfeld RS, Kerns RD, Moore BA, Oberleitner L, Joy MT, Keneally N, Liong C, Carroll KM. The Feasibility and Acceptability of Groups for Pain Management in Methadone Maintenance Treatment. Journal Of Addiction Medicine 2014, 8: 338-344. PMID: 25100310, PMCID: PMC4177009, DOI: 10.1097/adm.0000000000000055.Peer-Reviewed Original ResearchConceptsMethadone maintenance treatmentMaintenance treatmentRelaxation trainingMultimodal pain management approachAcceptability of groupsCharacteristic pain intensityPain management interventionsMethadone-maintained patientsPain management approachesPain intensityPain managementSession attendancePainGroup singingDecreased anxietyMindful walkingPatientsTreatmentAttendanceGroupWalkingManagement interventionsAcceptability
2012
The Practitioner Proposes a Treatment Change and the Patient Declines: What to do next?
Falzer PR, Leventhal HL, Peters E, Fried TR, Kerns R, Michalski M, Fraenkel L. The Practitioner Proposes a Treatment Change and the Patient Declines: What to do next? Pain Practice 2012, 13: 215-226. PMID: 23462141, PMCID: PMC3668345, DOI: 10.1111/j.1533-2500.2012.00573.x.Peer-Reviewed Original Research
2010
Research design considerations for confirmatory chronic pain clinical trials: IMMPACT recommendations
Dworkin RH, Turk DC, Peirce-Sandner S, Baron R, Bellamy N, Burke LB, Chappell A, Chartier K, Cleeland CS, Costello A, Cowan P, Dimitrova R, Ellenberg S, Farrar JT, French JA, Gilron I, Hertz S, Jadad AR, Jay GW, Kalliomäki J, Katz NP, Kerns RD, Manning DC, McDermott MP, McGrath PJ, Narayana A, Porter L, Quessy S, Rappaport BA, Rauschkolb C, Reeve BB, Rhodes T, Sampaio C, Simpson DM, Stauffer JW, Stucki G, Tobias J, White RE, Witter J. Research design considerations for confirmatory chronic pain clinical trials: IMMPACT recommendations. Pain 2010, 149: 177-193. PMID: 20207481, DOI: 10.1016/j.pain.2010.02.018.Peer-Reviewed Original ResearchConceptsChronic pain clinical trialsPain clinical trialsClinical trialsPrimary efficacy analysisChronic pain trialsDemonstration of efficacyIMMPACT recommendationsResearch design considerationsAnalgesic effectPain trialsChronic painEfficacy analysisTypes of trialsConsensus meetingTreatment groupsNew interventionsTrue lackTrialsTrial phaseEfficacyMethodological weaknessesAssay sensitivityTreatmentSubstantial variabilityParticipant selection
2009
Two Brief Versions of the Multidimensional Pain Readiness to Change Questionnaire, Version 2 (MPRCQ2)
Nielson WR, Armstrong JM, Jensen MP, Kerns RD. Two Brief Versions of the Multidimensional Pain Readiness to Change Questionnaire, Version 2 (MPRCQ2). The Clinical Journal Of Pain 2009, 25: 48-57. PMID: 19158546, DOI: 10.1097/ajp.0b013e3181817ab4.Peer-Reviewed Original ResearchConceptsMultidimensional Pain ReadinessPain ReadinessMultidisciplinary treatment programBrief versionMultidisciplinary treatmentPain managementPain StagesRheumatic diseasesPatient readinessAuthor consensusTreatment programMeasures of readinessChange QuestionnaireDay programFace validityTreatmentPsychometric propertiesPresent studyQuestionnaireBrief scaleParent scaleVersion 2SubscalesCoping strategiesResponse burden
2007
Patient–Provider Interactions in the Management of Chronic Pain: Current Findings within the Context of Shared Medical Decision Making
Frantsve LM, Kerns RD. Patient–Provider Interactions in the Management of Chronic Pain: Current Findings within the Context of Shared Medical Decision Making. Pain Medicine 2007, 8: 25-35. PMID: 17244101, DOI: 10.1111/j.1526-4637.2007.00250.x.Peer-Reviewed Original ResearchConceptsHealth care providersChronic painPatient-provider interactionsCare providersPain concernsCollaborative treatment decisionsShared medical decisionChronic pain conditionsPatient-provider communicationNonspecific treatment factorsMedical decisionsPain conditionsFemale patientsTreatment decisionsPatientsPainTreatment factorsProvider interactionsLife concernsTreatmentCurrent findingsCommunication trainingProvidersPossible mechanismFindings
2005
Intersession coping skill practice mediates the relationship between readiness for self-management treatment and goal accomplishment
Heapy A, Otis J, Marcus KS, Frantsve LM, Janke E, Shulman M, Bellmore W, Kerns RD. Intersession coping skill practice mediates the relationship between readiness for self-management treatment and goal accomplishment. Pain 2005, 118: 360-368. PMID: 16289803, DOI: 10.1016/j.pain.2005.09.004.Peer-Reviewed Original ResearchConceptsSelf-management treatmentCognitive behavioral therapySelf-management approachPain treatmentChronic painVA primary care clinicsPrimary care clinicsPain ReadinessCare clinicsPain StagesPatient readinessPrimary careImproved outcomesTreatment benefitTreatment goalsSkills practicePractice recommendationsAdherence ratingsAdherenceChange QuestionnairePSOCQPainPatientsTreatmentSelf-efficacy ratings
2004
The Future of Health Psychology Interventions
Nicassio PM, Meyerowitz BE, Kerns RD. The Future of Health Psychology Interventions. Health Psychology 2004, 23: 132-137. PMID: 15008656, DOI: 10.1037/0278-6133.23.2.132.Peer-Reviewed Original ResearchConceptsHealth psychology interventionsPublic health benefitsAdoption of treatmentsChronic illnessPsychology interventionsComplementary treatmentClinical inputClinical settingEffectiveness studiesMedical symptomsTreatment effectivenessPsychophysiological disordersHealth benefitsClinical applicationIntervention approachesInterventionTreatmentIndividual differencesSymptomsIllnessContextual factors
2003
Initial development and validation of a multidimensional pain readiness to change questionnaire
Nielson WR, Jensen MP, Kerns RD. Initial development and validation of a multidimensional pain readiness to change questionnaire. Journal Of Pain 2003, 4: 148-158. PMID: 14622712, DOI: 10.1054/jpai.2003.436.Peer-Reviewed Original ResearchConceptsMultidimensional Pain ReadinessPain ReadinessMultidisciplinary pain management programMultidisciplinary pain treatmentPain management programPain management skillsSpinal cord injurySelf-manage painPain treatmentChronic painFibromyalgia syndromeCord injuryPatient readinessInterindividual responseMaladaptive painClinical utilityPainAcquired amputationsConstruct validityReplication samplePreliminary supportPresent studyQuestionnaireSuch questionnairesTreatment
2000
HIV/AIDS-related Pain as a Chronic Pain Condition: Implications of a Biopsychosocial Model for Comprehensive Assessment and Effective Management
Marcus K, Kerns R, Rosenfeld B, Breitbart W. HIV/AIDS-related Pain as a Chronic Pain Condition: Implications of a Biopsychosocial Model for Comprehensive Assessment and Effective Management. Pain Medicine 2000, 1: 260-273. PMID: 15101893, DOI: 10.1046/j.1526-4637.2000.00033.x.Peer-Reviewed Original ResearchHIV/AIDSHIV/AIDS patientsChronic pain conditionsChronic pain assessmentBiopsychosocial modelNegative psychosocial impactPain conditionsPain treatmentChronic painPain assessmentAIDS patientsMultimodal treatmentHigh prevalencePainPsychosocial barriersPsychosocial impactSubstance abuseTreatment issuesPsychosocial contributionsTreatmentAppropriate assessmentPrevalenceAIDSCurrent literatureSpecific recommendations
1985
Comparison of Cognitive-Behavioral and Behavioral Approaches to the Outpatient Treatment of Chronic Pain
Kerns R, Turk D, Holzman A, Rudy T. Comparison of Cognitive-Behavioral and Behavioral Approaches to the Outpatient Treatment of Chronic Pain. The Clinical Journal Of Pain 1985, 1: 195-203. DOI: 10.1097/00002508-198501040-00003.Peer-Reviewed Original ResearchChronic painOutpatient treatmentChronic pain refractoryList control conditionWaiting list conditionHealth care systemPain refractoryPain severitySurgical treatmentActive treatmentClinical efficacyInstrumental activitiesTreatment phasePatientsPainAffective distressCare systemTreatmentList conditionCB treatmentCognitive behavioralSelf-report measuresMultiple self-report measuresControl conditionPresent study