2012
Susceptibility to Progressive Cryptococcus neoformans Pulmonary Infection Is Regulated by Loci on Mouse Chromosomes 1 and 9
Carroll SF, Lafferty EI, Flaczyk A, Fujiwara TM, Homer R, Morgan K, Loredo-Osti JC, Qureshi ST. Susceptibility to Progressive Cryptococcus neoformans Pulmonary Infection Is Regulated by Loci on Mouse Chromosomes 1 and 9. Infection And Immunity 2012, 80: 4167-4176. PMID: 22988020, PMCID: PMC3497416, DOI: 10.1128/iai.00417-12.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChromosomes, MammalianCryptococcosisCryptococcus neoformansCytokinesGenetic Predisposition to DiseaseLungLung Diseases, FungalMiceMice, Inbred C3HMice, Inbred CBAQuantitative Trait LociTh1 CellsTh2 CellsConceptsC3H/HeN miceCBA/J miceHeN micePulmonary infectionJ miceFungal burdenSusceptible C3H/HeN miceInterleukin-5Cryptococcus neoformans Pulmonary InfectionIL-13 protein expressionHigher pulmonary expressionLung fungal burdenGoblet cell metaplasiaTh2 immune responsePathogenesis of pneumoniaIL-17 proteinCBA/JCryptococcal pneumoniaGreater airwayTissue neutrophiliaCryptococcal infectionCell metaplasiaIntratracheal infectionPulmonary inflammationTissue eosinophilia
2008
A SNP in a let-7 microRNA Complementary Site in the KRAS 3′ Untranslated Region Increases Non–Small Cell Lung Cancer Risk
Chin LJ, Ratner E, Leng S, Zhai R, Nallur S, Babar I, Muller RU, Straka E, Su L, Burki EA, Crowell RE, Patel R, Kulkarni T, Homer R, Zelterman D, Kidd KK, Zhu Y, Christiani DC, Belinsky SA, Slack FJ, Weidhaas JB. A SNP in a let-7 microRNA Complementary Site in the KRAS 3′ Untranslated Region Increases Non–Small Cell Lung Cancer Risk. Cancer Research 2008, 68: 8535-8540. PMID: 18922928, PMCID: PMC2672193, DOI: 10.1158/0008-5472.can-08-2129.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerCase-control studyLung cancer riskIndependent case-control studiesLung cancerSingle nucleotide polymorphismsCancer riskNon-small cell lung cancer riskCell lung cancer riskVariant allelesCell lung cancerKRAS 3' untranslated regionLung cancer susceptibilityUnidentified single-nucleotide polymorphismsNSCLC patientsModerate smokersNSCLC cancerNSCLC casesCancer deathKRAS overexpressionCancerCancer susceptibilityOncogene expressionPatientsRisk
2005
Cutting Edge: TLR4 Deficiency Confers Susceptibility to Lethal Oxidant Lung Injury
Zhang X, Shan P, Qureshi S, Homer R, Medzhitov R, Noble PW, Lee PJ. Cutting Edge: TLR4 Deficiency Confers Susceptibility to Lethal Oxidant Lung Injury. The Journal Of Immunology 2005, 175: 4834-4838. PMID: 16210584, DOI: 10.4049/jimmunol.175.8.4834.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisGene Transfer TechniquesGenetic Predisposition to DiseaseHeme Oxygenase-1HyperoxiaLungMiceMice, KnockoutOxidantsToll-Like Receptor 4ConceptsTLR4-deficient miceLung injuryAntioxidant gene heme oxygenase-1Gene heme oxygenase-1Oxidant lung injuryBcl-2Heme oxygenase-1Life-sustaining measuresPhospho-Akt levelsNovel mechanistic linkRespiratory failureIll patientsLung integrityMurine modelOxygenase-1Oxidant stressProtective roleHost responseInnate immunityInjuryPhospho-AktHyperoxiaConfer susceptibilityMiceMammalian TLR4