2004
Airway hyper‐reactivity mediated by B‐1 cell immunoglobulin M antibody generating complement C5a at 1 day post‐immunization in a murine hapten model of non‐atopic asthma
Kawikova I, Paliwal V, Szczepanik M, Itakura A, Fukui M, Campos RA, Geba GP, Homer RJ, Iliopoulou BP, Pober JS, Tsuji RF, Askenase PW. Airway hyper‐reactivity mediated by B‐1 cell immunoglobulin M antibody generating complement C5a at 1 day post‐immunization in a murine hapten model of non‐atopic asthma. Immunology 2004, 113: 234-245. PMID: 15379984, PMCID: PMC1782564, DOI: 10.1111/j.1365-2567.2004.01936.x.Peer-Reviewed Original ResearchConceptsAirflow obstructionImmune cellsC5a receptor-deficient miceSubsequent airway challengeNon-atopic asthmaReceptor-deficient miceImmunoglobulin M antibodiesIgM-producing cellsWild-type miceIgM monoclonal antibodyAirway reactivityHapten challengeHapten modelAirway challengeMethacholine challengeAsthma modelSkin immunizationLymph nodesNaive miceNaïve recipientsM antibodiesDays postimmunizationSubsequent airwayMale miceComplement C5a
1997
Airway isocyanate-adducts in asthma induced by exposure to hexamethylene diisocyanate.
Redlich CA, Karol MH, Graham C, Homer RJ, Holm CT, Wirth JA, Cullen MR. Airway isocyanate-adducts in asthma induced by exposure to hexamethylene diisocyanate. Scandinavian Journal Of Work, Environment & Health 1997, 23: 227-31. PMID: 9243734, DOI: 10.5271/sjweh.203.Peer-Reviewed Original ResearchConceptsHuman bronchial biopsiesHuman lung tissueExposure-disease relationshipsAirway eosinophilsAirway histologyEpithelial exposureMethacholine challengeBronchial biopsiesEndobronchial biopsyInflammatory changesClinical featuresAirway biopsiesIsocyanate asthmaLung tissueT cellsImmunohistochemical stainingAsthmaBiopsyExposure patternsBronchoscopyExposureAirwayPatientsEosinophilsHistology