2013
7T MR spectroscopic imaging in the localization of surgical epilepsy
Pan JW, Duckrow RB, Gerrard J, Ong C, Hirsch LJ, Resor SR, Zhang Y, Petroff O, Spencer S, Hetherington HP, Spencer DD. 7T MR spectroscopic imaging in the localization of surgical epilepsy. Epilepsia 2013, 54: 1668-1678. PMID: 23895497, PMCID: PMC3938332, DOI: 10.1111/epi.12322.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAspartic AcidCreatineElectroencephalographyEpilepsy, Temporal LobeFemaleHumansMagnetic Resonance SpectroscopyMaleMiddle AgedTreatment OutcomeYoung AdultConceptsSevere metabolic abnormalitiesLocalization-related epilepsyMR spectroscopic imagingN-acetyl aspartateComplete resectionMetabolic abnormalitiesBetter outcomesMedial temporal lobe epilepsyResection regionTemporal lobe epilepsyNAA/CrSeizure onset zoneSurgical resectionLobe epilepsySurgical approachSeizure localizationMetabolic dysfunctionInternational LeagueSurgical epilepsyGray matterEpilepsyResectionAbnormalitiesMRSI abnormalitiesOutcome prediction
2012
Metabolic networks in epilepsy by MR spectroscopic imaging
Pan JW, Spencer DD, Kuzniecky R, Duckrow RB, Hetherington H, Spencer SS. Metabolic networks in epilepsy by MR spectroscopic imaging. Acta Neurologica Scandinavica 2012, 126: 411-420. PMID: 22574807, PMCID: PMC3600585, DOI: 10.1111/j.1600-0404.2012.01665.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBrainElectroencephalographyEpilepsy, Temporal LobeFemaleHumansMagnetic Resonance SpectroscopyMaleMetabolic Networks and PathwaysYoung AdultConceptsMTLE patientsBasal gangliaEpileptic networkMesial temporal lobe epilepsy patientsTemporal lobe epilepsy patientsLimbic seizure propagationBilateral basal gangliaNAA/CrMR spectroscopicIpsilateral insulaSeizure propagationBilateral hippocampusEpilepsy patientsHuman studiesIndependent factorsPatientsNeuronal functionThalamusGangliaEpilepsyInsulaFactor analysisFactorsHippocampusInjurySelective homonuclear polarization transfer for spectroscopic imaging of GABA at 7T
Pan JW, Duckrow RB, Spencer DD, Avdievich NI, Hetherington HP. Selective homonuclear polarization transfer for spectroscopic imaging of GABA at 7T. Magnetic Resonance In Medicine 2012, 69: 310-316. PMID: 22505305, PMCID: PMC3407348, DOI: 10.1002/mrm.24283.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsBrainEpilepsyGamma-Aminobutyric AcidHumansMagnetic Resonance SpectroscopyNeurotransmitter AgentsProtonsReproducibility of ResultsSensitivity and SpecificityConceptsEpilepsy patientsN-acetyl aspartate ratioSupplementary motor areaControl volunteersThalamic GABAMotor areaAspartate ratioGABAGABA resonancePatientsSingle-shot methodHuman brainPolarization transfer methodsPolarization transferMacromolecule resonancesHomonuclear polarization transferSpectroscopic imagingThalamusSuppression pulses