1995
Decreased cerebral blood flow during acute hyperglycemia
Duckrow R. Decreased cerebral blood flow during acute hyperglycemia. Brain Research 1995, 703: 145-150. PMID: 8719626, DOI: 10.1016/0006-8993(95)01077-7.Peer-Reviewed Original ResearchConceptsAcute hyperglycemiaCerebral blood flow decreasesPlasma osmolalityBlood flow decreasePentobarbital-anesthetized ratsCerebral blood flowLaser Doppler flowmetryAcute elevationMannitol injectionCBF increaseIntraperitoneal injectionTransient depressionBlood flowBaseline levelsHyperglycemiaElectroencephalographic activityTransient increaseFlow decreasesCBFOsmolalityBrief transient increaseInjectionContinuous measureFlowmetryRats
1992
Hyperglycemia and Blood-Brain Barrier Glucose Transport
Pelligrino DA, LaManna JC, Duckrow RB, Bryan RM, Harik SI. Hyperglycemia and Blood-Brain Barrier Glucose Transport. Cerebrovascular And Brain Metabolism Reviews 1992, 12: 887-899. PMID: 1400643, DOI: 10.1038/jcbfm.1992.126.Peer-Reviewed Original Research
1990
Effect of hemodilution on regional cerebral blood flow during chronic hyperglycemia in rats.
Duckrow RB. Effect of hemodilution on regional cerebral blood flow during chronic hyperglycemia in rats. Stroke 1990, 21: 1072-1076. PMID: 2368109, DOI: 10.1161/01.str.21.7.1072.Peer-Reviewed Original ResearchConceptsRegional cerebral blood flowCerebral blood flowReduced regional cerebral blood flowAverage cerebral blood flowChronic hyperglycemiaBlood flowElevated hematocritBrain regionsCerebral blood flow decreasesRegional cerebral blood flow decreasesBlood flow decreaseEffect of hemodilutionIsovolemic hemodilutionRestrained ratsHyperglycemiaHemodilutionHematocritRatsFlow decreasesStreptozotocinDissection
1988
Glucose transfer into rat brain during acute and chronic hyperglycemia
Duckrow R. Glucose transfer into rat brain during acute and chronic hyperglycemia. Metabolic Brain Disease 1988, 3: 201-209. PMID: 3221811, DOI: 10.1007/bf00999236.Peer-Reviewed Original ResearchConceptsPermeability-surface area productChronic hyperglycemiaBrain capillary permeability-surface area productBlood-brain barrierBrain glucose contentAcute hyperglycemiaGlucose transportIntraperitoneal injectionHyperglycemic ratsRestrained ratsRat brainHyperglycemiaCapillary permeability-surface area productGlucose transferRatsFacilitated glucose transportArea productBrain
1987
Regional Cerebral Glucose Utilization During Hyperglycemia
Duckrow R, Bryan R. Regional Cerebral Glucose Utilization During Hyperglycemia. Journal Of Neurochemistry 1987, 48: 989-993. PMID: 2949062, DOI: 10.1111/j.1471-4159.1987.tb05614.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCerebrovascular CirculationGlucoseHyperglycemiaKineticsMaleRatsRats, Inbred StrainsStreptozocinConceptsRegional cerebral blood flowRegional cerebral glucose utilizationCerebral glucose utilizationChronic hyperglycemiaAcute hyperglycemiaGlucose utilizationCerebral blood flowCerebral metabolic rateMetabolic rateIntraperitoneal injectionRestrained ratsRCMRglBlood flowHyperglycemiaKetone bodiesOxidative metabolismBrainPrevious dataStreptozotocinDecreaseRatsWeeksRegional cerebral blood flow decreases during chronic and acute hyperglycemia.
Duckrow RB, Beard DC, Brennan RW. Regional cerebral blood flow decreases during chronic and acute hyperglycemia. Stroke 1987, 18: 52-58. PMID: 2949400, DOI: 10.1161/01.str.18.1.52.Peer-Reviewed Original ResearchConceptsRegional cerebral blood flowChronic hyperglycemiaAcute hyperglycemiaPlasma glucoseAcute elevationCerebral blood flow decreasesRegional cerebral blood flow decreasesIschemic cell damageBlood flow decreasePresence of hyperglycemiaCerebral blood flowMicrons/Blood flow changesAwake restrained ratsFlow reductionBrain ischemiaNeuronal damageStroke patientsCardiac arrestBlood glucosePeritoneal spaceRestrained ratsBlood flowForebrain regionsHyperglycemia
1985
Regional cerebral blood flow decreases during hyperglycemia
Duckrow R, Beard D, Brennan R. Regional cerebral blood flow decreases during hyperglycemia. Annals Of Neurology 1985, 17: 267-272. PMID: 3922283, DOI: 10.1002/ana.410170308.Peer-Reviewed Original ResearchConceptsRegional cerebral blood flowBrain ischemiaCerebral blood flow decreasesRegional cerebral blood flow decreasesStroke-related morbidityBlood flow decreasePlasma osmolalityPresence of hyperglycemiaCerebral blood flowEffects of hyperglycemiaAcute hyperglycemiaPlasma glucoseIntraperitoneal injectionNormal salineAwake ratsRestrained ratsBlood flowQuantitative autoradiographyHyperglycemiaExperimental animalsFlow limitationIschemiaRatsOsmolalityGlucose