2016
Elevated basal glutamate and unchanged glutamine and GABA in refractory epilepsy: Microdialysis study of 79 patients at the yale epilepsy surgery program
Çavuş I, Romanyshyn JC, Kennard JT, Farooque P, Williamson A, Eid T, Spencer SS, Duckrow R, Dziura J, Spencer DD. Elevated basal glutamate and unchanged glutamine and GABA in refractory epilepsy: Microdialysis study of 79 patients at the yale epilepsy surgery program. Annals Of Neurology 2016, 80: 35-45. PMID: 27129611, DOI: 10.1002/ana.24673.Peer-Reviewed Original ResearchConceptsGABA levelsEpilepsy patientsΓ-aminobutyric acid (GABA) neurotransmissionGlutamine levelsGABAergic antiepileptic drugsEpilepsy surgery programRefractory epilepsy patientsCommon pathological featureAberrant glutamateAnn NeurolNonepileptogenic cortexSeizure-onset sitesRefractory epilepsyBasal glutamateAntiepileptic drugsCortical lesionsMicrodialysis studyPatient groupInterictal levelsPathological featuresDifferent etiologiesNeocortical epilepsyGlutamate levelsSeizure generationElectroencephalogram evaluation
2012
Selective homonuclear polarization transfer for spectroscopic imaging of GABA at 7T
Pan JW, Duckrow RB, Spencer DD, Avdievich NI, Hetherington HP. Selective homonuclear polarization transfer for spectroscopic imaging of GABA at 7T. Magnetic Resonance In Medicine 2012, 69: 310-316. PMID: 22505305, PMCID: PMC3407348, DOI: 10.1002/mrm.24283.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsBrainEpilepsyGamma-Aminobutyric AcidHumansMagnetic Resonance SpectroscopyNeurotransmitter AgentsProtonsReproducibility of ResultsSensitivity and SpecificityConceptsEpilepsy patientsN-acetyl aspartate ratioSupplementary motor areaControl volunteersThalamic GABAMotor areaAspartate ratioGABAGABA resonancePatientsSingle-shot methodHuman brainPolarization transfer methodsPolarization transferMacromolecule resonancesHomonuclear polarization transferSpectroscopic imagingThalamusSuppression pulses