2018
Sudden unexpected death in epilepsy in patients treated with brain‐responsive neurostimulation
Devinsky O, Friedman D, Duckrow RB, Fountain NB, Gwinn RP, Leiphart JW, Murro AM, Van Ness PC. Sudden unexpected death in epilepsy in patients treated with brain‐responsive neurostimulation. Epilepsia 2018, 59: 555-561. PMID: 29336029, DOI: 10.1111/epi.13998.Peer-Reviewed Original ResearchConceptsSudden unexpected deathDefinite SUDEPEpileptiform activityUnexpected deathBrain-responsive neurostimulationFrequent epileptiform activityDrug Administration approvalRNS SystemTime of deathSUDEP ratesWitnessed seizurePlacebo armResective surgerySUDEP riskClinical featuresImplant yearAdministration approvalClinical trialsEpilepsy patientsSUDEPPatientsSeizuresDrug studiesU.S. FoodDeath
1992
Regional coherence and the transfer of ictal activity during seizure onset in the medial temporal lobe
Duckrow R, Spencer S. Regional coherence and the transfer of ictal activity during seizure onset in the medial temporal lobe. Clinical Neurophysiology 1992, 82: 415-422. PMID: 1375548, DOI: 10.1016/0013-4694(92)90046-k.Peer-Reviewed Original ResearchConceptsMedial temporal lobeSeizure onsetTemporal lobeBrain regionsSustained seizure activityHippocampal depth electrodesHuman medial temporal lobeConsecutive patientsResective surgerySeizure dischargesSeizure activityEpileptiform activityIctal activityPosterior hippocampusDepth electrodesNeuronal entrainmentTransient increaseIctal periodNeuronal synchronizationPossible resective surgeryEEG activityOnsetLobeAdjacent contactsSec epochs