2007
Small bowel carcinoid (enterochromaffin cell) neoplasia exhibits transforming growth factor–β1‐mediated regulatory abnormalities including up‐regulation of C‐Myc and MTA1
Kidd M, Modlin IM, Pfragner R, Eick GN, Champaneria MC, Chan AK, Camp RL, Mane SM. Small bowel carcinoid (enterochromaffin cell) neoplasia exhibits transforming growth factor–β1‐mediated regulatory abnormalities including up‐regulation of C‐Myc and MTA1. Cancer 2007, 109: 2420-2431. PMID: 17469181, DOI: 10.1002/cncr.22725.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, WesternCadherinsCarcinoid TumorCell ProliferationCells, CulturedCyclin-Dependent Kinase Inhibitor p21Enterochromaffin CellsGene Expression Regulation, NeoplasticHistone DeacetylasesHumansIntestinal NeoplasmsMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3PhosphorylationProto-Oncogene Proteins c-mycRepressor ProteinsSignal TransductionSmad ProteinsTrans-ActivatorsTransforming Growth Factor beta1Tumor Cells, CulturedUp-RegulationConceptsEffects of TGFbeta1Normal EC cellsC-MycDownstream targetsEC cellsSmad2 phosphorylationE-cadherinCell proliferationEC cell proliferationProtein expressionGrowth regulatory mechanismsCandidate downstream targetsTranscriptional networksC-Myc pathwayC-myc transcriptsGrowth promotionCytostatic programGene responsesEC cell linesRegulatory mechanismsTranscript expressionTranscriptsNuclear translocationTumor cellsMTA1
2006
Genetic Differentiation of Appendiceal Tumor Malignancy
Modlin IM, Kidd M, Latich I, Zikusoka MN, Eick GN, Mane SM, Camp RL. Genetic Differentiation of Appendiceal Tumor Malignancy. Annals Of Surgery 2006, 244: 52-60. PMID: 16794389, PMCID: PMC1570599, DOI: 10.1097/01.sla.0000217617.06782.d5.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdolescentAdultAgedAged, 80 and overAntigens, NeoplasmApoptosis Regulatory ProteinsAppendiceal NeoplasmsAppendicitisBiomarkers, TumorCarcinoid TumorCell Cycle ProteinsChildChromogranin AChromograninsDiagnosis, DifferentialFemaleGene ExpressionGenetic MarkersHistone DeacetylasesHumansImmunohistochemistryMaleMiddle AgedNLR ProteinsNuclear ProteinsNucleosome Assembly Protein 1Repressor ProteinsReverse Transcriptase Polymerase Chain ReactionTrans-ActivatorsConceptsAppropriate surgical managementAppendiceal carcinoidsAppendiceal tumorsSurgical managementMAGE-D2Malignant appendiceal tumorsAppendiceal adenocarcinoidAdenocarcinoid tumorCarcinoid tumorsHistologic evidenceIncidental lesionsColorectal cancerPathologic criteriaQ-RT-PCRAppendiceal tissueGene expressionNormal mucosaTumor potentialCarcinoidsTumor behaviorAppendicitisAdenocarcinoidMorphologic assessmentTumor typesTumor malignancyUtility of molecular genetic signatures in the delineation of gastric neoplasia
Kidd M, Modlin IM, Mane SM, Camp RL, Eick GN, Latich I, Zikusoka MN. Utility of molecular genetic signatures in the delineation of gastric neoplasia. Cancer 2006, 106: 1480-1488. PMID: 16502410, DOI: 10.1002/cncr.21758.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdenocarcinomaAdultAgedAntigens, NeoplasmCarcinoid TumorChromogranin AChromograninsDiagnosis, DifferentialFemaleGene Expression ProfilingGenetic MarkersHistone DeacetylasesHumansImmunohistochemistryMaleMiddle AgedNeoplasm InvasivenessOligonucleotide Array Sequence AnalysisPhenotypeRepressor ProteinsReverse Transcriptase Polymerase Chain ReactionStomach NeoplasmsTrans-ActivatorsConceptsType III/IVGastric carcinoidsMAGE-D2Gastric neoplasiaMolecular genetic signaturesType I/IIGenetic signaturesTumor invasionSimilar expression patternsCgA protein levelsProtein expression levelsII tumorsStromal tumorsClinical behaviorGastric adenocarcinomaGastric neoplasmsMTA1 levelsNormal mucosaImmunohistochemical analysisMolecular basisExpression patternsGene expressionTumorsGene signatureBiological rationaleThe Role of Genetic Markers— NAP1L1, MAGE-D2, and MTA1—in Defining Small-Intestinal Carcinoid Neoplasia
Kidd M, Modlin IM, Mane SM, Camp RL, Eick G, Latich I. The Role of Genetic Markers— NAP1L1, MAGE-D2, and MTA1—in Defining Small-Intestinal Carcinoid Neoplasia. Annals Of Surgical Oncology 2006, 13: 253-262. PMID: 16424981, DOI: 10.1245/aso.2006.12.011.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdultAgedAntigens, NeoplasmBiomarkers, TumorCarcinoid TumorCell Cycle ProteinsFemaleGenetic MarkersHistone DeacetylasesHumansIntestinal NeoplasmsIntestine, SmallMaleMiddle AgedNuclear ProteinsNucleosome Assembly Protein 1Repressor ProteinsReverse Transcriptase Polymerase Chain ReactionTissue Array AnalysisTrans-ActivatorsConceptsSmall intestinal carcinoidsQuantitative reverse transcriptase-polymerase chain reactionColorectal carcinomaMAGE-D2Primary tumorLymph node metastasisImmunohistochemical expression levelsReverse transcriptase-polymerase chain reactionNonmetastatic primary tumorsTranscriptase-polymerase chain reactionHealthy tissueGastrointestinal carcinoidsLN metastasisNode metastasisIntestinal carcinoidsPrognostic utilityHealthy mucosaMalignant potentialProstate carcinomaTissue microarrayImmunohistochemical methodsCarcinomaImmunohistochemical approachMetastasisCarcinoids