2010
The CCK2 receptor antagonist, YF476, inhibits Mastomys ECL cell hyperplasia and gastric carcinoid tumor development
Kidd M, Siddique ZL, Drozdov I, Gustafsson BI, Camp RL, Black JW, Boyce M, Modlin IM. The CCK2 receptor antagonist, YF476, inhibits Mastomys ECL cell hyperplasia and gastric carcinoid tumor development. Peptides 2010, 162: 52-60. PMID: 20144901, DOI: 10.1016/j.regpep.2010.01.009.Peer-Reviewed Original ResearchConceptsECL cell hyperplasiaECL cell secretionCell secretionCell hyperplasiaTumor developmentReceptor antagonistGastric ECL cell carcinoidsRodent speciesECL cell functionECL cell neoplasiaECL cell tumorsGastric neuroendocrine tumorsECL cell carcinoidsCell proliferationTumor formationAutocrine growth factorCCK2 receptor antagonistECL cell proliferationCell functionGrowth factorCarcinoid developmentAcid suppressionAtrophic gastritisCell carcinoidCell tumors
2007
Small bowel carcinoid (enterochromaffin cell) neoplasia exhibits transforming growth factor–β1‐mediated regulatory abnormalities including up‐regulation of C‐Myc and MTA1
Kidd M, Modlin IM, Pfragner R, Eick GN, Champaneria MC, Chan AK, Camp RL, Mane SM. Small bowel carcinoid (enterochromaffin cell) neoplasia exhibits transforming growth factor–β1‐mediated regulatory abnormalities including up‐regulation of C‐Myc and MTA1. Cancer 2007, 109: 2420-2431. PMID: 17469181, DOI: 10.1002/cncr.22725.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, WesternCadherinsCarcinoid TumorCell ProliferationCells, CulturedCyclin-Dependent Kinase Inhibitor p21Enterochromaffin CellsGene Expression Regulation, NeoplasticHistone DeacetylasesHumansIntestinal NeoplasmsMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3PhosphorylationProto-Oncogene Proteins c-mycRepressor ProteinsSignal TransductionSmad ProteinsTrans-ActivatorsTransforming Growth Factor beta1Tumor Cells, CulturedUp-RegulationConceptsEffects of TGFbeta1Normal EC cellsC-MycDownstream targetsEC cellsSmad2 phosphorylationE-cadherinCell proliferationEC cell proliferationProtein expressionGrowth regulatory mechanismsCandidate downstream targetsTranscriptional networksC-Myc pathwayC-myc transcriptsGrowth promotionCytostatic programGene responsesEC cell linesRegulatory mechanismsTranscript expressionTranscriptsNuclear translocationTumor cellsMTA1
2006
Role of CCN2/CTGF in the proliferation of Mastomys enterochromaffin-like cells and gastric carcinoid development
Kidd M, Modlin IM, Eick GN, Camp RL, Mane SM. Role of CCN2/CTGF in the proliferation of Mastomys enterochromaffin-like cells and gastric carcinoid development. AJP Gastrointestinal And Liver Physiology 2006, 292: g191-g200. PMID: 16950763, DOI: 10.1152/ajpgi.00131.2006.Peer-Reviewed Original ResearchConceptsNormal ECL cellsECL cell proliferationECL cell preparationCell proliferationNormal mucosaECL cellsEnterochromaffin-like cell proliferationERK1/2 phosphorylationERK1/2 inhibitor PD-98059Enterochromaffin-like cellsShort-term cultured cellsCell preparationsCCN2 proteinPD 98059Tumor cell proliferationCarcinoid developmentGastrin regulationGastric carcinoidsMitogenic growth factorsReal-time PCRGastric mucosaNeoplastic proliferationInhibitor PD 98059Carcinoid tissueECL cell transformation