Quantifying environmental adaptation of metabolic pathways in metagenomics
Gianoulis TA, Raes J, Patel PV, Bjornson R, Korbel JO, Letunic I, Yamada T, Paccanaro A, Jensen LJ, Snyder M, Bork P, Gerstein MB. Quantifying environmental adaptation of metabolic pathways in metagenomics. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 1374-1379. PMID: 19164758, PMCID: PMC2629784, DOI: 10.1073/pnas.0808022106.Peer-Reviewed Original ResearchConceptsMultiple environmental gradientsSpecific biological processesNutrient-limited conditionsDistinct environmental conditionsAmino acid transportMicrobial communitiesAmount of cofactorEnvironmental gradientsEnvironmental adaptationStrongest multivariate correlationsGenetic contentCofactor synthesisBiological processesMicrobial pathwaysMetabolic pathwaysAcid transportMetabolic footprintsAmino acidsParticular pathwayEnvironmental differencesEnvironmental variablesEnvironmental conditionsPathwayMetabolic differencesGeographic sites