2024
Memory-related brain potentials for visual objects in early AD show impairment and compensatory mechanisms
Xia J, Kutas M, Salmon D, Stoermann A, Rigatuso S, Farias S, Edland S, Brewer J, Olichney J. Memory-related brain potentials for visual objects in early AD show impairment and compensatory mechanisms. Cerebral Cortex 2024, 34: bhae398. PMID: 39390709, DOI: 10.1093/cercor/bhae398.Peer-Reviewed Original ResearchConceptsEvent-related brain potentialsAmnestic mild cognitive impairmentHippocampal occupancyBrain potentialsMemory abilityNegative ERP effectExecutive function abilitiesVisual memory abilityImpaired episodic memoryVerbal memory abilitiesAlzheimer's diseaseInvestigate neural mechanismsObject recognition taskVisual object recognitionVisual object recognition taskCognitively unimpaired participantsMild cognitive impairmentERP effectsNeuropsychological measuresExecutive functionEpisodic memoryHippocampal functionCompensatory mechanismsVisual memoryNeural mechanisms
2018
Precision medicine screening using whole-genome sequencing and advanced imaging to identify disease risk in adults
Perkins B, Caskey C, Brar P, Dec E, Karow D, Kahn A, Hou Y, Shah N, Boeldt D, Coughlin E, Hands G, Lavrenko V, Yu J, Procko A, Appis J, Dale A, Guo L, Jönsson T, Wittmann B, Bartha I, Ramakrishnan S, Bernal A, Brewer J, Brewerton S, Biggs W, Turpaz Y, Venter J. Precision medicine screening using whole-genome sequencing and advanced imaging to identify disease risk in adults. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: 3686-3691. PMID: 29555771, PMCID: PMC5889622, DOI: 10.1073/pnas.1706096114.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCardiovascular DiseasesDiseaseFemaleGenetic Predisposition to DiseaseHigh-Throughput Nucleotide SequencingHumansImage Processing, Computer-AssistedMaleMiddle AgedMutationNeoplasmsNervous System DiseasesPrecision MedicineRisk AssessmentSequence Analysis, RNAWhole Genome SequencingYoung AdultConceptsChronic disease riskPremature mortalitySymptom-free adultsAge-related chronic diseasesDisease riskDual-energy X-ray absorptiometryChronic diseasesPrecision medicine screeningsAssociated with premature mortalityFamily medical historyStudy of screeningAdvanced imagingWhole-genome sequencingClinical testingActive adultsMedicine screeningX-ray absorptiometryImprove preventionHealthy lifeCardiac rhythm monitoringWhole-body MRIBlood testsCardiovascular diseaseVariant interpretationAdults