2022
Comprehensive Analysis of Metabolic Isozyme Targets in Cancer
Marczyk M, Gunasekharan V, Casadevall D, Qing T, Foldi J, Sehgal R, Shan NL, Blenman KRM, O'Meara TA, Umlauf S, Surovtseva YV, Muthusamy V, Rinehart J, Perry RJ, Kibbey R, Hatzis C, Pusztai L. Comprehensive Analysis of Metabolic Isozyme Targets in Cancer. Cancer Research 2022, 82: 1698-1711. PMID: 35247885, PMCID: PMC10883296, DOI: 10.1158/0008-5472.can-21-3983.Peer-Reviewed Original ResearchConceptsPotential therapeutic targetAcetyl-CoA carboxylase 1Therapeutic targetCancer typesCell linesBreast cancer viabilityPatient-derived xenograftsNovel metabolic targetsCorresponding cell linesExpression patternsDrug treatmentMatching normal tissuesRelated commentaryTumor growthMalignant transformationSmall molecule inhibitionCancer viabilityCancer Cell Line EncyclopediaNormal tissuesMetabolic vulnerabilitiesCarboxylase 1Anticancer therapyCellular changesCell proliferationMetabolic reprogramming
2015
GLP‐2 reprograms glucose metabolism in intestinal stem cells
Shi X, Alves T, Zeng X, Kibbey R, Estes M, Guan X. GLP‐2 reprograms glucose metabolism in intestinal stem cells. The FASEB Journal 2015, 29 DOI: 10.1096/fasebj.29.1_supplement.851.4.Peer-Reviewed Original ResearchMetabolic reprogrammingIntestinal stem cellsCell proliferationMetabolic fluxStem cellsAmino acid biosynthesisGlycolysis-dependent mannerDe novo biosynthesisPyruvate kinase M2Reprograms glucose metabolismIntracellular metabolic fluxesCellular functionsAcid biosynthesisCrypt stem cellsNovo biosynthesisReprogrammingNovel roleKinase M2Aerobic glycolysisBiosynthesisGLP-2Intestinal crypt cell proliferationNuclear translocationCellular mechanismsGlycolytic intermediates