2016
Caregiver burden as a predictor of depression among family and friends who provide care for persons with bipolar disorder
Perlick D, Berk L, Kaczynski R, Gonzalez J, Link B, Dixon L, Grier S, Miklowitz D. Caregiver burden as a predictor of depression among family and friends who provide care for persons with bipolar disorder. Bipolar Disorders 2016, 18: 183-191. PMID: 27004622, DOI: 10.1111/bdi.12379.Peer-Reviewed Original ResearchConceptsCaregiver burdenDepressive symptomsClinical statusBipolar disorderCaregiver depressionSystematic Treatment Enhancement ProgramOverall caregiver burdenPatient's clinical statusCaregiver depressive symptomsPredictors of depressionAdult patientsSymptomsPrimary caregiversSociodemographic variablesCaregiversDisordersDepressionBaselineDisorder reportBurdenPatientsStrongest predictorOne-thirdSocial supportPredictors
2012
Rumination, gender, and depressive symptoms associated with caregiving strain in bipolar disorder
Perlick D, Gonzalez J, Michael L, Huth M, Culver J, Kaczynski R, Calabrese J, Miklowitz D. Rumination, gender, and depressive symptoms associated with caregiving strain in bipolar disorder. Acta Psychiatrica Scandinavica 2012, 126: 356-362. PMID: 22607486, PMCID: PMC3870006, DOI: 10.1111/j.1600-0447.2012.01874.x.Peer-Reviewed Original ResearchConceptsDepressive symptomsCaregiver strainBipolar disorderSystematic Treatment Enhancement ProgramAffective Disorders EvaluationPatient's clinical statusClinical Monitoring FormGreater caregiver strainCross-sectional studyRuminative styleClinical statusLifetime diagnosisPatientsDisorder evaluationSymptomsFemale caregiversPrimary caregiversMonitoring formCaregiversMild levelsDisordersDepressionFamily strainApparent associationFamily members
2009
Impact of antipsychotic medication on family burden in schizophrenia: Longitudinal results of CATIE trial
Perlick DA, Rosenheck RA, Kaczynski R, Swartz MS, Canive JM, Lieberman JA. Impact of antipsychotic medication on family burden in schizophrenia: Longitudinal results of CATIE trial. Schizophrenia Research 2009, 116: 118-125. PMID: 19864114, DOI: 10.1016/j.schres.2009.09.026.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntipsychotic AgentsAttitude to HealthCaregiversCost-Benefit AnalysisDouble-Blind MethodFamilyFemaleHumansLongitudinal StudiesMaleMiddle AgedPsychiatric Status Rating ScalesQuality of LifeRegression AnalysisSchizophreniaSchizophrenic PsychologySeverity of Illness IndexStatistics, NonparametricTreatment OutcomeConceptsSecond-generation antipsychoticsSecond-generation drugsFamily burdenTreatment assignmentInitial treatment assignmentSecond-generation medicationsClinical Antipsychotic TrialsEvidence of superiorityMedication changesCATIE trialInitial medicationPatient's symptomsAntipsychotic medicationAntipsychotic TrialsDaily livingFamily caregiversService useSide effectsMedicationsSecondary analysisPatientsIntervention effectivenessBurden factorsTrialsAntipsychotics
2008
Correlates of subjective and objective burden among caregivers of patients with bipolar disorder
Ostacher M, Nierenberg A, Iosifescu D, Eidelman P, Lund H, Ametrano R, Kaczynski R, Calabrese J, Miklowitz D, Sachs G, Perlick D, Group T. Correlates of subjective and objective burden among caregivers of patients with bipolar disorder. Acta Psychiatrica Scandinavica 2008, 118: 49-56. PMID: 18582347, DOI: 10.1111/j.1600-0447.2008.01201.x.Peer-Reviewed Original ResearchConceptsCaregiver burdenPatient depressionBipolar disorderObjective burdenPrimary caregiversSystematic Treatment Enhancement ProgramCaregivers of patientsChronicity of symptomsSubjective caregiver burdenBipolar depressionPatient's coursePatient daysMood symptomsMood elevationPatientsPatient dataDisordersDepressionCaregiversBurdenSymptomsEpisodesPrevious yearDaysChronicityCaregiver Burden and Health in Bipolar Disorder
Perlick DA, Rosenheck RA, Miklowitz DJ, Kaczynski R, Link B, Ketter T, Wisniewski S, Wolff N, Sachs G. Caregiver Burden and Health in Bipolar Disorder. The Journal Of Nervous And Mental Disease 2008, 196: 484-491. PMID: 18552626, PMCID: PMC4006696, DOI: 10.1097/nmd.0b013e3181773927.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdultAffectAgedBipolar DisorderCaregiversCluster AnalysisCost of IllnessDefense MechanismsFemaleHealth BehaviorHealth StatusHumansLongitudinal StudiesMaleMiddle AgedPersonality InventoryPrejudicePsychiatric Status Rating ScalesSelf CareSocial SupportStress, PsychologicalConceptsService useBipolar disorderHealth outcomesDifferent health-related outcomesLess service useSubgroups of caregiversHealth-related outcomesBetter health outcomesAdverse health effectsCaregiver burdenHigh burdenPrimary caregiversCaregiversHealth effectsMixed effects modelsEffective caregiversOutcomesEffects modelSocial supportDisordersCoping levelsBurdenGroupHealthLow mastery
2007
Association of symptomatology and cognitive deficits to functional capacity in schizophrenia
Perlick DA, Rosenheck RA, Kaczynski R, Bingham S, Collins J. Association of symptomatology and cognitive deficits to functional capacity in schizophrenia. Schizophrenia Research 2007, 99: 192-199. PMID: 17851042, DOI: 10.1016/j.schres.2007.08.009.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAdministration, OralAdultAntipsychotic AgentsBenzodiazepinesCognition DisordersDose-Response Relationship, DrugDouble-Blind MethodEmploymentFemaleFollow-Up StudiesHaloperidolHumansMaleMiddle AgedNeuropsychological TestsOlanzapinePsychiatric Status Rating ScalesPsychotic DisordersQuality of LifeSchizophreniaSchizophrenic PsychologySocial AdjustmentVeteransConceptsFunctional statusQLS total scoreFunctional capacityDouble-blind clinical trialDSM-IV-diagnosed schizophreniaTotal scoreNon-institutionalized peopleFine motor coordinationEffect of symptomsHeinrichs-Carpenter QualityNeurocognitive factorsStudy entryOral olanzapineClinical trialsMotor coordinationSchizoaffective disorderNegative symptomsCognitive deficitsSymptomsSchizophreniaPANSSMixed effects modelsLife ScaleVerbal memoryPatientsCurrent Suicide Ideation and Prior Suicide Attempts of Bipolar Patients as Influences on Caregiver Burden
Chessick C, Perlick D, Miklowitz D, Kaczynski R, Allen M, Morris C, Marangell L, STED‐BD Family Experience Collaborative Study Group. Current Suicide Ideation and Prior Suicide Attempts of Bipolar Patients as Influences on Caregiver Burden. Suicide And Life-Threatening Behavior 2007, 37: 482-491. PMID: 17896888, DOI: 10.1521/suli.2007.37.4.482.Peer-Reviewed Original ResearchConceptsCurrent suicidal ideationSuicide attemptsSuicidal ideationBipolar patientsLower general health scoresGeneral health scoresCaregivers of patientsParents of patientsPositive lifetime historyPrior suicide attemptsLevel of depressionCross-sectional designCaregiver burdenHealth scoresPatientsLifetime historyRole dysfunctionPoor healthCaregiversLifetime attemptsIdeationSuicide ideationBurdenMore burdenCurrent suicide ideation
2006
Special Section on CATIE Baseline Data: Components and Correlates of Family Burden in Schizophrenia
Perlick D, Rosenheck R, Kaczynski R, Swartz M, Cañive J, Lieberman J. Special Section on CATIE Baseline Data: Components and Correlates of Family Burden in Schizophrenia. Psychiatric Services 2006, 57: 1117-1125. PMID: 16870962, DOI: 10.1176/ps.2006.57.8.1117.Peer-Reviewed Original ResearchConceptsMedication side effectsQuality of lifeDaily livingService useSide effectsAcute inpatient phaseImpact of symptomsPatient problem behaviorsClinical Antipsychotic TrialsPatient's symptomsCaregiver burdenInpatient phaseAntipsychotic TrialsFamily burdenFamily caregiversCaregiver dataPatient behaviorTreatment programPatients' impairmentIncorporation of skillsSymptomsIntervention effectivenessDemographic characteristicsPrevious monthSchizophreniaModeling costs and burden of informal caregiving for persons with bipolar disorder.
Wolff N, Perlick D, Kaczynski R, Calabrese J, Nierenberg A, Miklowitz D. Modeling costs and burden of informal caregiving for persons with bipolar disorder. The Journal Of Mental Health Policy And Economics 2006, 9: 99-110. PMID: 17007487.Peer-Reviewed Original Research
2005
Use of mental health and primary care services by caregivers of patients with bipolar disorder: a preliminary study
Perlick DA, Hohenstein JM, Clarkin JF, Kaczynski R, Rosenheck RA. Use of mental health and primary care services by caregivers of patients with bipolar disorder: a preliminary study. Bipolar Disorders 2005, 7: 126-135. PMID: 15762853, DOI: 10.1111/j.1399-5618.2004.00172.x.Peer-Reviewed Original ResearchConceptsHealth service usePrimary care service useCare service useService useBipolar disorderCaregiver burdenPsychological distressMedical conditionsHealth servicesElevated health service useMental health service usePoor self-rated healthMental healthCaregivers of patientsPrimary care servicesResearch Diagnostic CriteriaLogistic regression analysisCaregiver psychological distressSelf-rated healthCaregivers of relativesSymptoms of anxietyHierarchical logistic regression analysisBurden caregiversPatient symptomatologyCaregiver depression